个人详细信息
周波

周波

周波教授 (Professor Bo Zhou) 博士生导师。男,1971年1月生。1993年毕业于赣南师范学院化学系,1997年和2000年在兰州大学先后获有机化学硕士和博士学位。2000年-2004年在兰州大学生命科学学院和功能有机分子化学国家重点实验室从事博士后研究。2004年至今在兰州大学化学化工学院工作。现为中国生物物理学会自由基生物学与医学专业委员会委员。2006年入选教育部“新世纪优秀人才支持计划”。作为第一参加人完成的“生物抗氧化剂的化学和生物化学基础研究”项目获2006年甘肃省高校科技进步一等奖。申请人主要研究领域是自由基化学和自由基生物学、生物有机和药物化学 。目前的兴趣集中于生物抗氧化剂的结构修饰及其活性机制和基于生物抗氧化剂的癌预防药物分子设计。已在国际学术刊物上如Chem. Eur. J., Free Radic. Biol. Med., J. Org. Chem., Org. Lett., Adv. Synth. Catal., J. Agric. Food Chem., Food Chem.等发表论文50余篇。
个人详细信息

研究成果

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[1] Wang, HB,Jin, XL,Zheng, JF,et al. Developing Piperlongumine-directed Glutathione S-transferase Inhibitors By An Electrophilicity-based Strategy[J]. European Journal Of Medicinal Chemistry,2017,126:517-525.
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[2] Chen, ZQ,Zhang, L,Yu, JT,et al. Identification Of Resveratrol Derivative 3,3 ',4,4 ',5,5 '-hexamethoxy-trans-stilbene As A Novel Pro-angiogenic Small-molecule Compound[J]. European Journal Of Pharmacology,2016,791:185-194.
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[3] 张文学,黄安平,徐人威,等. 二氧化碳还原制甲醇方法[J]. 现代化工,2015,35(7):37-41.
浏览/下载:10/0
[4] Yan, WJ,Wang, Q,Yuan, CH,et al. Designing Piperlongumine-directed Anticancer Agents By An Electrophilicity-based Prooxidant Strategy: A Mechanistic Investigation[J]. Free Radical Biology And Medicine,2016,97:109-123.
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[5] Lin, D,Dai, F,Sun, LD,et al. Toward An Understanding Of The Role Of A Catechol Moiety In Cancer Chemoprevention: The Case Of Copper- And O-quinone-dependent Nrf2 Activation By A Catechol-type Resveratrol Analog[J]. Molecular Nutrition & Food Research,2015,59(12):2395-2406.
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[6] Shen, T,Jiang, T,Long, M,et al. A Curcumin Derivative That Inhibits Vinyl Carbamate-induced Lung Carcinogenesis Via Activation Of The Nrf2 Protective Response[J]. Antioxidants & Redox Signaling,2015,23(8):651-664.
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[7] Li, Y,Zhang, LP,Dai, F,et al. Hexamethoxylated Monocarbonyl Analogues Of Curcumin Cause G2/m Cell Cycle Arrest In Nci-h460 Cells Via Michael Acceptor-dependent Redox Intervention[J]. Journal Of Agricultural And Food Chemistry,2015,63(35):7731-7742.
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[8] Dai, F,Liu, GY,Li, Y,et al. Insights Into The Importance For Designing Curcumin-inspired Anticancer Agents By A Prooxidant Strategy: The Case Of Diarylpentanoids[J]. Free Radical Biology And Medicine,2015,85:127-137.
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[9] Sun, LD,Wang, F,Dai, F,et al. Development And Mechanism Investigation Of A New Piperlongumine Derivative As A Potent Anti-inflammatory Agent[J]. Biochemical Pharmacology,2015,95(3):156-169.
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[10] Song, JX,Sun, YR,Peluso, I,et al. A Novel Curcumin Analog Binds To And Activates Tfeb In Vitro And In Vivo Independent Of Mtor Inhibition[J]. Autophagy,2016,12(8):1372-1389.
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研究主题

Antioxidant[11] Resveratrol[7] 抗氧化剂[7] resveratrol[6] DNA damage[6] Apoptosis[4] reactive oxygen species[4] 姜黄素[4] Mechanism[4] Reactive oxygen species[4] 二苯乙烯[3] caffeic acid[3] Reduction[3] Copper[3] curcumin[3]

成果统计

合作作者[TOP 5]

 

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