个人详细信息
房建国

房建国

房建国教授(Professor Jian-Guo Fang),博士生导师。男,1977年11月生。1998年兰州大学化学系毕业获有机化学学士学位,2003年兰州大学化学化工学院毕业获有机化学博士学位。从2003年9月到2008年12月分别在瑞典Karolinska Institute,美国Burnham Institute for Medical Research和美国西北大学从事博士后研究。2008年至今在兰州大学化学化工学院功能有机分子化学国家重点实验室工作。主要研究领域是化学生物学和药物化学。目前的兴趣集中于天然活性小分子化合物与生物体内某些具有重要生理功能的蛋白的相互作用机制研究。现承担兰州大学“萃英计划”引进人才专项项目,为国家自然科学基金委有机化学创新群体骨干成员。2006年获甘肃省高校科技进步一等奖。已在国际学术刊物上如Science, Proc. Natl. Acad. Sci. U. S. A., J. Am. Chem. Soc., J. Biol. Chem., Cancer Res., Chem. Eur. J., J. Med. Chem., Free Radic. Biol. Med., J. Agric. Food Chem.等发表论文20余篇。
个人详细信息

研究成果

52 2236 2 21
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[1] Ma, HL,Zhang, JM,Zhang, ZZ,et al. A Fast Response And Red Emission Probe For Mammalian Thioredoxin Reductase[J]. Chemical Communications,2016,52(3-21):12060-12063.
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[2] Fu, GC,Yang, ZD,Zhou, SY,et al. Wortmannines A-c, Three Novel Wortmannin Derivatives With An Unusual Five-membered B Ring From The Endophytic Fungus Talaromyces Wortmannii Lgt-4[J]. Tetrahedron Letters,2016,57(2-10):4608-4611.
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[3] Zhang, JM,Yao, J,Peng, SJ,et al. Securinine Disturbs Redox Homeostasis And Elicits Oxidative Stress-mediated Apoptosis Via Targeting Thioredoxin Reductase[J]. Biochimica Et Biophysica Acta-molecular Basis Of Disease,2017,1863(1-1):129-138.
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[4] Fu, ZH,Han, X,Shao, YL,et al. Fluorescein-based Chromogenic And Ratiometric Fluorescence Probe For Highly Selective Detection Of Cysteine And Its Application In Bioimaging[J]. Analytical Chemistry,2017,89(1-3):1937-1944.
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[5] Duan, DZ,Zhang, JM,Yao, J,et al. Targeting Thioredoxin Reductase By Parthenolide Contributes To Inducing Apoptosis Of Hela Cells[J]. Journal Of Biological Chemistry,2016,291(19):10021-10031.
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[6] Yang, YJ,Yao, J,Jin, XJ,et al. Sesquiterpenoids And Tirucallane Triterpenoids From The Roots Of Scorzonera Divaricata[J]. Phytochemistry,2016,124:86-98.
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[7] Zhou, PC,Yao, J,Hu, GD,et al. Naphthalimide Scaffold Provides Versatile Platform For Selective Thiol Sensing And Protein Labeling[J]. Acs Chemical Biology,2016,11(4):1098-1105.
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[8] Zhang, JM,Li, Y,Duan, DZ,et al. Inhibition Of Thioredoxin Reductase By Alantolactone Prompts Oxidative Stress-mediated Apoptosis Of Hela Cells[J]. Biochemical Pharmacology,2016,102:34-44.
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[9] Peng, SJ,Zhang, BX,Meng, XK,et al. Synthesis Of Piperlongumine Analogues And Discovery Of Nuclear Factor Erythroid 2-related Factor 2 (nrf2) Activators As Potential Neuroprotective Agents[J]. Journal Of Medicinal Chemistry,2015,58(13):5242-5255.
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[10] Xu, YZ,Cu, XY,Peng, SJ,et al. Design, Synthesis And Biological Evaluation Of Novel Sesquiterpene Mustards As Potential Anticancer Agents[J]. European Journal Of Medicinal Chemistry,2015,94:284-297.
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研究主题

resveratrol[8] antioxidant[7] lipid peroxidation[5] Apoptosis[4] Redox[3] Oxidative stress[3] Thioredoxin[3] Thioredoxin reductase[3] Reactive oxygen species[3] antioxidation[2] Cytotoxicity[2] Nrf2[2] structure-activity relationship[2] Structure elucidation[2] neuroprotection[2]

成果统计

合作作者[TOP 5]

 

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