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题名: Design and synthesis of paracaseolide A analogues as selective protein tyrosine phosphatase 1B inhibitors
作者: Yin, JP; Tang, CL; Gao, LX; Ma, WP; Li, JY; Li, Y(李瀛); Li, J; Nan, FJ
收录类别: SCIE ; EI ; MEDLINE
出版日期: 2014
刊名: ORGANIC & BIOMOLECULAR CHEMISTRY
卷号: 12, 期号:21, 页码:3441-3445
英文摘要: A series of structurally related analogues of the natural product paracaseolide A were synthesized and identified as potent PTP1B inhibitors. Among these analogues, compound 10 in particular showed improved PTP1B enzyme inhibitory activity, high selectivity for PTP1B over TC-PTP, and improved cellular effects.
作者部门: [Yin, Jian-Peng ; Li, Ying] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China ; [Tang, Chun-Lan ; Gao, Li-Xin ; Ma, Wei-Ping ; Li, Jing-Ya ; Li, Jia ; Nan, Fa-Jun] Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai 201203, Peoples R China
通讯作者: Li, Y (reprint author), Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China.
学科分类: Chemistry
文章类型: Article
所属项目编号: National Program on Key Basic Research Project [2012CB524906] ; National Natural Science Foundation of China [81125023] ; Shanghai Commission of Science and Technology [13DZ2290300]
所属项目名称: 国家自然科学基金项目 ; 国家重点基础研究发展计划以及国家重大科学研究计划(973计划)
项目资助者: NSFC ; MOST
语种: 英语
DOI: 10.1039/c4ob00214h
ISSN号: 1477-0520
WOS记录号: WOS:000336023400018
EI记录号: 20142017720140
PM记录号: 24752625
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/103080
Appears in Collections:化学化工学院_期刊论文

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Recommended Citation:
Yin, JP,Tang, CL,Gao, LX,et al. Design and synthesis of paracaseolide A analogues as selective protein tyrosine phosphatase 1B inhibitors[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2014,12(21):3441-3445.
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