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题名: Bioantioxidants: From chemistry to biology
作者: Zhou, B(周波); Liu, ZL(刘中立)
收录类别: SCIE ; CPCI-S
出版日期: 2005-11-01
会议名称: 17th International Conference on Physical Organic Chemistry (ICPOC-17)
会议日期: AUG 15-20, 2004
会议地点: Shanghai, PEOPLES R CHINA
英文摘要: Bioantioxidants, or dietary antioxidants, are dietary substances in food that significantly decrease the adverse effects of reactive oxygen species (ROS) on normal physiological functions in humans. Inhibition of ROS-induced oxidative damages by supplementation of bioantioxidants, the so-called "antioxidant therapy", has become an attractive therapeutic strategy to reduce the risk of ROS-related diseases and has led to flourishing research in the past decade. However, many questions dealing with the correlation between chemical and biological activities, the bioavailability and "non-antioxidant" effects of bioantioxidants are still under debate. This article outlines our current kinetic and mechanistic studies on naturally occurring antioxidants, including vitamin E, green tea polyphenols (GOHs), and resveratrol, as well as their synthetic analogs in micelles, in red blood cells, in low-density lipoprotein (LDL) and in microsomes. The cytotoxicity and apoptosis-inducing activity of these antioxidants against cancer cells were also studied. It was found that there was significant correlation between the chemical and biological antioxidant activities, as well as between the antioxidant activity and the cytotoxic and apoptosis-inducing activities.
关键词: peroxidation ; antioxidation ; vitamin E ; green tea polyphenols ; resveratrol ; apoptosis
作者部门: Lanzhou Univ, Natl Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China
通讯作者: Liu, ZL (reprint author), Lanzhou Univ, Natl Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China.
学科分类: Chemistry
会议录: PURE AND APPLIED CHEMISTRY
期号: 11
页码: 1887-1903
出版者: INT UNION PURE APPLIED CHEMISTRY
出版地: RES TRIANGLE PK
语种: 英语
DOI: 10.1351/pac200577111887
ISSN号: 0033-4545
WOS记录号: WOS:000233572200008
第一机构:
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内容类型: 会议论文
URI标识: http://ir.lzu.edu.cn/handle/262010/113158
Appears in Collections:化学化工学院_会议论文

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Recommended Citation:
Zhou, B,Liu, ZL. Bioantioxidants: From chemistry to biology[C]. 见:17th International Conference on Physical Organic Chemistry (ICPOC-17). Shanghai, PEOPLES R CHINA. AUG 15-20, 2004.
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