兰州大学机构库 >化学化工学院
Bioantioxidants: From chemistry to biology
Zhou, B(周波); Liu, ZL(刘中立); Liu, ZL (reprint author), Lanzhou Univ, Natl Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China.
2005-11-01
Conference Name17th International Conference on Physical Organic Chemistry (ICPOC-17)
Source PublicationPURE AND APPLIED CHEMISTRY
Issue11
Pages1887-1903
DepartmentLanzhou Univ, Natl Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China
Conference DateAUG 15-20, 2004
Conference PlaceShanghai, PEOPLES R CHINA
Publication PlaceRES TRIANGLE PK
AbstractBioantioxidants, or dietary antioxidants, are dietary substances in food that significantly decrease the adverse effects of reactive oxygen species (ROS) on normal physiological functions in humans. Inhibition of ROS-induced oxidative damages by supplementation of bioantioxidants, the so-called "antioxidant therapy", has become an attractive therapeutic strategy to reduce the risk of ROS-related diseases and has led to flourishing research in the past decade. However, many questions dealing with the correlation between chemical and biological activities, the bioavailability and "non-antioxidant" effects of bioantioxidants are still under debate. This article outlines our current kinetic and mechanistic studies on naturally occurring antioxidants, including vitamin E, green tea polyphenols (GOHs), and resveratrol, as well as their synthetic analogs in micelles, in red blood cells, in low-density lipoprotein (LDL) and in microsomes. The cytotoxicity and apoptosis-inducing activity of these antioxidants against cancer cells were also studied. It was found that there was significant correlation between the chemical and biological antioxidant activities, as well as between the antioxidant activity and the cytotoxic and apoptosis-inducing activities.
Keywordperoxidation antioxidation vitamin E green tea polyphenols resveratrol apoptosis
Subject AreaChemistry
DOI10.1351/pac200577111887
PublisherINT UNION PURE APPLIED CHEMISTRY
Indexed BySCIE ; CPCI-S
Language英语
ISSN0033-4545
WOS IDWOS:000233572200008
First Inst
Citation statistics
Cited Times:23[WOS]   [WOS Record]     [Related Records in WOS]
Document Type会议论文
Identifierhttp://ir.lzu.edu.cn/handle/262010/113158
Collection化学化工学院
Corresponding AuthorLiu, ZL (reprint author), Lanzhou Univ, Natl Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China.
Recommended Citation
GB/T 7714
Zhou, B,Liu, ZL,Liu, ZL . Bioantioxidants: From chemistry to biology[C]. RES TRIANGLE PK,2005:1887-1903.
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