兰州大学机构库 >化学化工学院
Bioantioxidants: From chemistry to biology
Zhou, B(周波); Liu, ZL(刘中立); Liu, ZL (reprint author), Lanzhou Univ, Natl Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China.
2005-11-01
会议名称17th International Conference on Physical Organic Chemistry (ICPOC-17)
会议录名称PURE AND APPLIED CHEMISTRY
期号11
页码1887-1903
作者部门Lanzhou Univ, Natl Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China
会议日期AUG 15-20, 2004
会议地点Shanghai, PEOPLES R CHINA
出版地RES TRIANGLE PK
摘要Bioantioxidants, or dietary antioxidants, are dietary substances in food that significantly decrease the adverse effects of reactive oxygen species (ROS) on normal physiological functions in humans. Inhibition of ROS-induced oxidative damages by supplementation of bioantioxidants, the so-called "antioxidant therapy", has become an attractive therapeutic strategy to reduce the risk of ROS-related diseases and has led to flourishing research in the past decade. However, many questions dealing with the correlation between chemical and biological activities, the bioavailability and "non-antioxidant" effects of bioantioxidants are still under debate. This article outlines our current kinetic and mechanistic studies on naturally occurring antioxidants, including vitamin E, green tea polyphenols (GOHs), and resveratrol, as well as their synthetic analogs in micelles, in red blood cells, in low-density lipoprotein (LDL) and in microsomes. The cytotoxicity and apoptosis-inducing activity of these antioxidants against cancer cells were also studied. It was found that there was significant correlation between the chemical and biological antioxidant activities, as well as between the antioxidant activity and the cytotoxic and apoptosis-inducing activities.
关键词peroxidation antioxidation vitamin E green tea polyphenols resveratrol apoptosis
学科领域Chemistry
DOI10.1351/pac200577111887
出版者INT UNION PURE APPLIED CHEMISTRY
收录类别SCIE ; CPCI-S
语种英语
ISSN号0033-4545
WOS记录号WOS:000233572200008
第一机构
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文献类型会议论文
条目标识符http://ir.lzu.edu.cn/handle/262010/113158
Collection化学化工学院
通讯作者Liu, ZL (reprint author), Lanzhou Univ, Natl Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China.
Recommended Citation:
GB/T 7714
Zhou, B,Liu, ZL,Liu, ZL . Bioantioxidants: From chemistry to biology[C]. RES TRIANGLE PK,2005:1887-1903.
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