兰州大学机构库 >生命科学学院
The yak genome and adaptation to life at high altitude
Indexed BySCIE ; PubMed ; MEDLINE ; BIOSIS
2012-08
Source PublicationNATURE GENETICS
ISSN1061-4036
Volume44Issue:8Pages:946-+
AbstractDomestic yaks (Bos grunniens) provide meat and other necessities for Tibetans living at high altitude on the Qinghai-Tibetan Plateau and in adjacent regions. Comparison between yak and the closely related low-altitude cattle (Bos taurus) is informative in studying animal adaptation to high altitude. Here, we present the draft genome sequence of a female domestic yak generated using Illumina-based technology at 65-fold coverage. Genomic comparisons between yak and cattle identify an expansion in yak of gene families related to sensory perception and energy metabolism, as well as an enrichment of protein domains involved in sensing the extracellular environment and hypoxic stress. Positively selected and rapidly evolving genes in the yak lineage are also found to be significantly enriched in functional categories and pathways related to hypoxia and nutrition metabolism. These findings may have important implications for understanding adaptation to high altitude in other animal species and for hypoxia-related diseases in humans.
Subject AreaGenetics & Heredity
PublisherNATURE PUBLISHING GROUP
Publication PlaceNEW YORK
DOI10.1038/ng.2343
First Inst
Language英语
Project NumberNatural Science Foundation of China [30725004, 40972018] ; Ministry of Science and Technology of China [2010DFB63500] ; International Collaboration 111 Projects of China ; 985 and 211 Projects of Lanzhou University ; Shenzhen Municipal Government [ZYC200903240077A] ; Hundreds-Talent Program from the Chinese Academy of Sciences
Funding Project国家自然科学基金项目 ; 国家国际科技合作专项 ; 高等学校学科创新引智计划(111计划)
Funding OrganizationNSFC ; MOST ; MOE ; SAFEA ; LZU
SubtypeArticle
WOS IDWOS:000306854700023
PMID 22751099
BIOSIS IDBIOSIS:PREV201200581654
Department
[Qiu, Qiang;
Ma, Tao;
Hu, Quanjun;
Zhou, Ran;
Wang, Lizhong;
Wang, Kun;
Lu, Xu;
Ma, Hui;
Zhang, Jian;
Wang, Zhaofeng...更多
Citation statistics
Cited Times:361[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.lzu.edu.cn/handle/262010/115204
Collection生命科学学院
Corresponding AuthorLiu, JQ (reprint author), Lanzhou Univ, Coll Life Sci, State Key Lab Grassland Agroecosyst, Lanzhou 730000, Peoples R China.
Recommended Citation
GB/T 7714
Qiu, Q,Zhang, GJ,Ma, T,et al. The yak genome and adaptation to life at high altitude[J]. NATURE GENETICS,2012,44(8):946-+.
APA Qiu, Q.,Zhang, GJ.,Ma, T.,Qian, WB.,Wang, JY.,...&Liu, JQ .(2012).The yak genome and adaptation to life at high altitude.NATURE GENETICS,44(8),946-+.
MLA Qiu, Q,et al."The yak genome and adaptation to life at high altitude".NATURE GENETICS 44.8(2012):946-+.
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