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题名: The yak genome and adaptation to life at high altitude
作者: Qiu, Q(邱强); Zhang, GJ; Ma, T; Qian, WB; Wang, JY; Ye, ZQ; Cao, CC; Hu, QJ; Kim, J; Larkin, DM; Auvil, L; Capitanu, B; Ma, J; Lewin, HA; Qian, XJ; Lang, YS; Zhou, R; Wang, LZ; Wang, K; Xia, JQ; Liao, SG; Pan, SK; Lu, X; Hou, HL; Wang, Y; Zang, XT; Yin, Y; Ma, H; Zhang, J; Wang, ZF(王召锋); Zhang, YM(张迎梅); Zhang, DW(张大伟); Yonezawa, T; Hasegawa, M; Zhong, Y; Liu, WB; Zhang, Y; Huang, ZY; Zhang, SX(张胜祥); Long, RJ(龙瑞军); Yang, HM; Wang, J; Lenstra, JA; Cooper, DN; Wu, Y(武一); Wang, J; Shi, P; Wang, J; Liu, JQ(刘建全)
收录类别: SCIE ; MEDLINE ; BIOSIS
出版日期: 2012-08
刊名: NATURE GENETICS
卷号: 44, 期号:8, 页码:946-+
英文摘要: Domestic yaks (Bos grunniens) provide meat and other necessities for Tibetans living at high altitude on the Qinghai-Tibetan Plateau and in adjacent regions. Comparison between yak and the closely related low-altitude cattle (Bos taurus) is informative in studying animal adaptation to high altitude. Here, we present the draft genome sequence of a female domestic yak generated using Illumina-based technology at 65-fold coverage. Genomic comparisons between yak and cattle identify an expansion in yak of gene families related to sensory perception and energy metabolism, as well as an enrichment of protein domains involved in sensing the extracellular environment and hypoxic stress. Positively selected and rapidly evolving genes in the yak lineage are also found to be significantly enriched in functional categories and pathways related to hypoxia and nutrition metabolism. These findings may have important implications for understanding adaptation to high altitude in other animal species and for hypoxia-related diseases in humans.
作者部门: [Qiu, Qiang ; Ma, Tao ; Hu, Quanjun ; Zhou, Ran ; Wang, Lizhong ; Wang, Kun ; Lu, Xu ; Ma, Hui ; Zhang, Jian ; Wang, Zhaofeng ; Zhang, Yingmei ; Zhang, Dawei ; Zhang, Shengxiang ; Long, Ruijun ; Wu, Yi ; Liu, Jianquan] Lanzhou Univ, Coll Life Sci, State Key Lab Grassland Agroecosyst, Lanzhou 730000, Peoples R China ; [Zhang, Guojie ; Qian, Wubin ; Wang, Junyi ; Cao, Changchang ; Qian, Xiaoju ; Lang, Yongshan ; Xia, Jinquan ; Liao, Shengguang ; Pan, Shengkai ; Hou, Haolong ; Wang, Yan ; Zang, Xuetao ; Yin, Ye ; Liu, Wenbin ; Zhang, Yan ; Huang, Zhiyong ; Yang, Huanming ; Wang, Jian ; Wang, Jun ; Wang, Jian] Beijing Genom Inst BGI Shenzhen, Shenzhen, Peoples R China ; [Ye, Zhiqiang ; Shi, Peng] Chinese Acad Sci, State Key Lab Genet Resources & Evolut, Inst Kunming Zool, Kunming, Peoples R China ; [Ye, Zhiqiang] Chinese Acad Sci, Grad Sch, Beijing, Peoples R China ; [Kim, Jaebum ; Ma, Jian] Univ Illinois, Inst Genom Biol, Urbana, IL USA ; [Kim, Jaebum] Konkuk Univ, Dept Anim Biotechnol, Seoul, South Korea ; [Larkin, Denis M.] Aberystwyth Univ, Inst Biol Environm & Rural Sci, Aberystwyth, Ceredigion, Wales ; [Auvil, Loretta ; Capitanu, Boris] Univ Illinois, Natl Ctr Supercomp Applicat, Urbana, IL USA ; [Ma, Jian] Univ Illinois, Dept Bioengn, Urbana, IL USA ; [Lewin, Harris A.] Univ Calif Davis, Dept Ecol & Evolut, Davis, CA 95616 USA ; [Yonezawa, Takahiro ; Hasegawa, Masami ; Zhong, Yang] Fudan Univ, Sch Life Sci, Shanghai 200433, Peoples R China ; [Lenstra, Johannes A.] Univ Utrecht, Fac Vet Med, Utrecht, Netherlands ; [Cooper, David N.] Cardiff Univ, Inst Med Genet, Sch Med, Cardiff, S Glam, Wales ; [Wang, Jun] Univ Copenhagen, Dept Biol, Copenhagen, Denmark ; [Liu, Jianquan] Sichuan Univ, Key Lab Bioresources & Ecoenvironm, Coll Life Sci, Chengdu 610064, Peoples R China
通讯作者: Liu, JQ (reprint author), Lanzhou Univ, Coll Life Sci, State Key Lab Grassland Agroecosyst, Lanzhou 730000, Peoples R China.
学科分类: Genetics & Heredity
文章类型: Article
所属项目编号: Natural Science Foundation of China [30725004, 40972018] ; Ministry of Science and Technology of China [2010DFB63500] ; International Collaboration 111 Projects of China ; 985 and 211 Projects of Lanzhou University ; Shenzhen Municipal Government [ZYC200903240077A] ; Hundreds-Talent Program from the Chinese Academy of Sciences
所属项目名称: 国家自然科学基金项目 ; 国家国际科技合作专项 ; 高等学校学科创新引智计划(111计划)
项目资助者: NSFC ; MOST ; MOE ; SAFEA ; LZU
语种: 英语
DOI: 10.1038/ng.2343
ISSN号: 1061-4036
WOS记录号: WOS:000306854700023
PM记录号: 22751099
BIOSIS记录号: BIOSIS:PREV201200581654
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/115204
Appears in Collections:生命科学学院_期刊论文

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