|The yak genome and adaptation to life at high altitude|
; Zhang, GJ
; Ma, T
; Qian, WB
; Wang, JY
; Ye, ZQ
; Cao, CC
; Hu, QJ
; Kim, J
; Larkin, DM
; Auvil, L
; Capitanu, B
; Ma, J
; Lewin, HA
; Qian, XJ
; Lang, YS
|Source Publication||NATURE GENETICS
|Abstract||Domestic yaks (Bos grunniens) provide meat and other necessities for Tibetans living at high altitude on the Qinghai-Tibetan Plateau and in adjacent regions. Comparison between yak and the closely related low-altitude cattle (Bos taurus) is informative in studying animal adaptation to high altitude. Here, we present the draft genome sequence of a female domestic yak generated using Illumina-based technology at 65-fold coverage. Genomic comparisons between yak and cattle identify an expansion in yak of gene families related to sensory perception and energy metabolism, as well as an enrichment of protein domains involved in sensing the extracellular environment and hypoxic stress. Positively selected and rapidly evolving genes in the yak lineage are also found to be significantly enriched in functional categories and pathways related to hypoxia and nutrition metabolism. These findings may have important implications for understanding adaptation to high altitude in other animal species and for hypoxia-related diseases in humans.|
|Subject Area||Genetics & Heredity
|Publisher||NATURE PUBLISHING GROUP
|Publication Place||NEW YORK
|Project Number||Natural Science Foundation of China [30725004, 40972018]
; Ministry of Science and Technology of China [2010DFB63500]
; International Collaboration 111 Projects of China
; 985 and 211 Projects of Lanzhou University
; Shenzhen Municipal Government [ZYC200903240077A]
; Hundreds-Talent Program from the Chinese Academy of Sciences
[Qiu, Qiang;Ma, Tao;Hu, Quanjun;Zhou, Ran;Wang, Lizhong;Wang, Kun;Lu, Xu;Ma, Hui;Zhang, Jian;Wang, Zhaofeng...更多
|Corresponding Author||Liu, JQ (reprint author), Lanzhou Univ, Coll Life Sci, State Key Lab Grassland Agroecosyst, Lanzhou 730000, Peoples R China.|
Qiu, Q,Zhang, GJ,Ma, T,et al. The yak genome and adaptation to life at high altitude[J].
Qiu, Q.,Zhang, GJ.,Ma, T.,Qian, WB.,Wang, JY.,...&Liu, JQ .(2012).The yak genome and adaptation to life at high altitude.NATURE GENETICS,44(8),946-+.
Qiu, Q,et al."The yak genome and adaptation to life at high altitude".NATURE GENETICS 44.8(2012):946-+.
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