兰州大学机构库 >生命科学学院
The yak genome and adaptation to life at high altitude
收录类别SCIE ; PubMed ; MEDLINE ; BIOSIS
2012-08
发表期刊NATURE GENETICS
卷号44期号:8页码:946-+
出版者NATURE PUBLISHING GROUP
出版地NEW YORK
摘要Domestic yaks (Bos grunniens) provide meat and other necessities for Tibetans living at high altitude on the Qinghai-Tibetan Plateau and in adjacent regions. Comparison between yak and the closely related low-altitude cattle (Bos taurus) is informative in studying animal adaptation to high altitude. Here, we present the draft genome sequence of a female domestic yak generated using Illumina-based technology at 65-fold coverage. Genomic comparisons between yak and cattle identify an expansion in yak of gene families related to sensory perception and energy metabolism, as well as an enrichment of protein domains involved in sensing the extracellular environment and hypoxic stress. Positively selected and rapidly evolving genes in the yak lineage are also found to be significantly enriched in functional categories and pathways related to hypoxia and nutrition metabolism. These findings may have important implications for understanding adaptation to high altitude in other animal species and for hypoxia-related diseases in humans.
作者部门
[Qiu, Qiang;
Ma, Tao;
Hu, Quanjun;
Zhou, Ran;
Wang, Lizhong;
Wang, Kun;
Lu, Xu;
Ma, Hui;
Zhang, Jian;
Wang, Zhaofeng...更多
学科领域Genetics & Heredity
所属项目编号Natural Science Foundation of China [30725004, 40972018] ; Ministry of Science and Technology of China [2010DFB63500] ; International Collaboration 111 Projects of China ; 985 and 211 Projects of Lanzhou University ; Shenzhen Municipal Government [ZYC200903240077A] ; Hundreds-Talent Program from the Chinese Academy of Sciences
资助项目国家自然科学基金项目 ; 国家国际科技合作专项 ; 高等学校学科创新引智计划(111计划)
项目资助者NSFC ; MOST ; MOE ; SAFEA ; LZU
DOI10.1038/ng.2343
ISSN1061-4036
文章类型Article
语种英语
WOS记录号WOS:000306854700023
PM记录号22751099
BIOSIS记录号BIOSIS:PREV201200581654
第一机构
Citation statistics
文献类型期刊论文
条目标识符http://ir.lzu.edu.cn/handle/262010/115204
Collection生命科学学院
通讯作者Liu, JQ (reprint author), Lanzhou Univ, Coll Life Sci, State Key Lab Grassland Agroecosyst, Lanzhou 730000, Peoples R China.
Recommended Citation:
GB/T 7714
Qiu, Q,Zhang, GJ,Ma, T,et al. The yak genome and adaptation to life at high altitude[J]. NATURE GENETICS,2012,44(8):946-+.
APA Qiu, Q.,Zhang, GJ.,Ma, T.,Qian, WB.,Wang, JY.,...&Liu, JQ .(2012).The yak genome and adaptation to life at high altitude.NATURE GENETICS,44(8),946-+.
MLA Qiu, Q,et al."The yak genome and adaptation to life at high altitude".NATURE GENETICS 44.8(2012):946-+.
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