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题名: ROS act as an upstream signal to mediate cadmium-induced mitophagy in mouse brain
作者: Wei, X; Qi, YM; Zhang, XN; Gu, XY; Cai, H; Yang, J; Zhang, YM(张迎梅)
收录类别: SCIE ; PubMed ; MEDLINE ; BIOSIS
出版日期: 2015-01
刊名: NEUROTOXICOLOGY
卷号: 46, 页码:19-24
出版者: ELSEVIER
出版地: AMSTERDAM
英文摘要: As a well known generator of reactive oxygen species (ROS), cadmium (Cd) is found to be an effective inducer of mitophagy in mouse kidney and liver cells. Here, we aim to elucidate whether Cd can also initiate mitophagy in mouse brain and what role ROS play in this process. Our results showed that Cd caused overproduction of ROS. Meanwhile, Cd induced mitophagy, as indicated by the collapse of mitochondrial membrane potential (MMP), formation of mitophagosomes, increases of PINK1 level and LC3-II/LC3-I ratio and decrease of mitochondrial mass. Scavenging of ROS by N-acetyl-L-cysteine (NAC) or acetyl-L-carnitine (ALC) rescued MMP and mitochondrial mass, and squelched PINK1 level, mitochondrial accumulation of Parkin and LC3-II/LC3-I ratio, suggesting that ROS were associated with Cd-induced mitophagy. Cyclosporine A (CsA), an inhibitor of mitophagy, blocked Cd-induced mitophagy and PINK1/Parkin pathway but failed to suppress ROS increase, revealing that ROS are the causes rather than the results of Cd-induced mitophagy. In conclusion, this study suggested that ROS functioned on the upstream of PINK1/Parkin pathway to mediate Cd-induced mitophagy. (C) 2014 Elsevier Inc. All rights reserved.
关键词: Cadmium ; Mitophagy ; ROS ; Brain ; Mouse
作者部门: [Wei, Xue ; Qi, Yongmei ; Zhang, Xiaoning ; Gu, Xueyan ; Yang, Jing ; Zhang, Yingmei] Lanzhou Univ, Sch Life Sci, Gansu Key Lab Biomonitoring & Bioremediat Environ, Lanzhou 730000, Peoples R China ; [Cai, Hui] Gansu Prov Hosp, Lanzhou 730030, Peoples R China
通讯作者: Zhang, YM (reprint author), Lanzhou Univ, Sch Life Sci, 222 South Tianshui RD, Lanzhou 730000, Peoples R China.
学科分类: Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology
文章类型: Article
所属项目编号: National Natural Science Foundation of China [31300941] ; Fundamental Research Funds for the Central Universities [lzujbky-2014-91] ; Traditional Chinese Medicine Research Fund of Gansu [GZK-2012-61] ; Program for Changjiang Scholars and Innovative Research Team in University [IRT1137]
所属项目名称: 国家自然科学基金项目 ; 长江学者和创新团队发展计划 ; 中央高校基本科研业务费专项资金
项目资助者: NSFC ; MOE ; LZU
语种: 英语
DOI: 10.1016/j.neuro.2014.11.007
ISSN号: 0161-813X
WOS记录号: WOS:000350390300003
PM记录号: 25464205
BIOSIS记录号: BCI:BCI201500306935
IR记录号: BCI:BCI201500306935
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/115579
Appears in Collections:生命科学学院_期刊论文

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Recommended Citation:
Wei, X,Qi, YM,Zhang, XN,et al. ROS act as an upstream signal to mediate cadmium-induced mitophagy in mouse brain[J]. NEUROTOXICOLOGY,2015,46:19-24.
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