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题名: Scavenging effects of natural phenols on oxidizing intermediates of peroxynitrite
作者: Zhao, CY; Shi, YM; Yao, SD; Jia, ZJ(贾忠建); Fan, BT; Wang, WF; Lin, WZ; Lin, NY; Zheng, RL(郑荣梁)
收录类别: SCIE ; MEDLINE
出版日期: 2003-10
刊名: PHARMAZIE
卷号: 58, 期号:10, 页码:742-749
英文摘要: Most of peroxynitrite (ONOO(-)/ONOOH) is formed via the diffusion-limited reaction between nitric oxide and superoxide. In biological systems, the decomposition of ONOO(-) yields 30-35% of carbonate radical (CO(3)(.-)) and nitrogen dioxide (NO(2)(.)), Which are strongly oxidizing intermediates and are suggested to take a part of the responsibility for the toxicity of nitric oxide (NO(.)) or ONOO(-). Therefore, the current study focuses on the scavenging activities of phenols toward CO(3)(.-) and NO(2)(.) to protect biomolecules from damage caused by NO(.) or ONOO(-) using the technique of pulse radiolysis. From the build-up kinetic of the phenoxyl radicals and the decay kinetic of CO(3)(.-) radical, the rate constants of scavenging reactions were determined to be 1.9-3.4 x 10(8) M(-1) (.) s(-1) and 0.11-1.9 x 10(8) M(-1) (.) s(-1) for CO(3)(.-) and NO(2)(.) respectively. The results indicated that the tested phenols are the efficient scavengers Of CO(3)(.-) and NO(2)(.).
作者部门: Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Peoples R China ; Chinese Acad Sci, Shanghai Inst Nucl Res, Lab Radiat Chem, Shanghai, Peoples R China ; Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China ; Univ Paris 07, Inst Topol & Dynam Syst, Paris, France
通讯作者: Zheng, RL (reprint author), Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Peoples R China.
学科分类: Pharmacology & Pharmacy; Chemistry
文章类型: Article
语种: 英语
ISSN号: 0031-7144
WOS记录号: WOS:000186193400013
PM记录号: 14609289
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/115692
Appears in Collections:生命科学学院_期刊论文

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