兰州大学机构库 >生命科学学院
Scavenging effects of natural phenols on oxidizing intermediates of peroxynitrite
Zhao, CY; Shi, YM; Yao, SD; Jia, ZJ(贾忠建); Fan, BT; Wang, WF; Lin, WZ; Lin, NY; Zheng, RL(郑荣梁); Zheng, RL (reprint author), Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Peoples R China.
Indexed BySCIE ; PubMed ; MEDLINE
2003-10
Source PublicationPHARMAZIE
Volume58Issue:10Pages:742-749
PublisherGOVI-VERLAG
Publication PlaceESCHBORN
AbstractMost of peroxynitrite (ONOO(-)/ONOOH) is formed via the diffusion-limited reaction between nitric oxide and superoxide. In biological systems, the decomposition of ONOO(-) yields 30-35% of carbonate radical (CO(3)(.-)) and nitrogen dioxide (NO(2)(.)), Which are strongly oxidizing intermediates and are suggested to take a part of the responsibility for the toxicity of nitric oxide (NO(.)) or ONOO(-). Therefore, the current study focuses on the scavenging activities of phenols toward CO(3)(.-) and NO(2)(.) to protect biomolecules from damage caused by NO(.) or ONOO(-) using the technique of pulse radiolysis. From the build-up kinetic of the phenoxyl radicals and the decay kinetic of CO(3)(.-) radical, the rate constants of scavenging reactions were determined to be 1.9-3.4 x 10(8) M(-1) (.) s(-1) and 0.11-1.9 x 10(8) M(-1) (.) s(-1) for CO(3)(.-) and NO(2)(.) respectively. The results indicated that the tested phenols are the efficient scavengers Of CO(3)(.-) and NO(2)(.).
DepartmentLanzhou Univ, Sch Life Sci, Lanzhou 730000, Peoples R China;
Chinese Acad Sci, Shanghai Inst Nucl Res, Lab Radiat Chem, Shanghai, Peoples R China;
Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China;
Univ Paris 07, Inst Topol & Dynam Syst, Paris, France
Subject AreaPharmacology & Pharmacy ; Chemistry
ISSN0031-7144
SubtypeArticle
Language英语
WOS IDWOS:000186193400013
PMID 14609289
First Inst
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.lzu.edu.cn/handle/262010/115692
Collection生命科学学院
Corresponding AuthorZheng, RL (reprint author), Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Peoples R China.
Recommended Citation
GB/T 7714
Zhao, CY,Shi, YM,Yao, SD,et al. Scavenging effects of natural phenols on oxidizing intermediates of peroxynitrite[J]. PHARMAZIE,2003,58(10):742-749.
APA Zhao, CY.,Shi, YM.,Yao, SD.,Jia, ZJ.,Fan, BT.,...&Zheng, RL .(2003).Scavenging effects of natural phenols on oxidizing intermediates of peroxynitrite.PHARMAZIE,58(10),742-749.
MLA Zhao, CY,et al."Scavenging effects of natural phenols on oxidizing intermediates of peroxynitrite".PHARMAZIE 58.10(2003):742-749.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Altmetrics Score
Google Scholar
Similar articles in Google Scholar
[Zhao, CY]'s Articles
[Shi, YM]'s Articles
[Yao, SD]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhao, CY]'s Articles
[Shi, YM]'s Articles
[Yao, SD]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhao, CY]'s Articles
[Shi, YM]'s Articles
[Yao, SD]'s Articles
Terms of Use
No data!
Social Bookmark/Share
No comment.
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.