兰州大学机构库 >生命科学学院
Scavenging effects of natural phenols on oxidizing intermediates of peroxynitrite
Zhao, CY; Shi, YM; Yao, SD; Jia, ZJ(贾忠建); Fan, BT; Wang, WF; Lin, WZ; Lin, NY; Zheng, RL(郑荣梁); Zheng, RL (reprint author), Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Peoples R China.
2003-10
发表期刊PHARMAZIE
ISSN0031-7144
卷号58期号:10页码:742-749
出版者GOVI-VERLAG
摘要Most of peroxynitrite (ONOO(-)/ONOOH) is formed via the diffusion-limited reaction between nitric oxide and superoxide. In biological systems, the decomposition of ONOO(-) yields 30-35% of carbonate radical (CO(3)(.-)) and nitrogen dioxide (NO(2)(.)), Which are strongly oxidizing intermediates and are suggested to take a part of the responsibility for the toxicity of nitric oxide (NO(.)) or ONOO(-). Therefore, the current study focuses on the scavenging activities of phenols toward CO(3)(.-) and NO(2)(.) to protect biomolecules from damage caused by NO(.) or ONOO(-) using the technique of pulse radiolysis. From the build-up kinetic of the phenoxyl radicals and the decay kinetic of CO(3)(.-) radical, the rate constants of scavenging reactions were determined to be 1.9-3.4 x 10(8) M(-1) (.) s(-1) and 0.11-1.9 x 10(8) M(-1) (.) s(-1) for CO(3)(.-) and NO(2)(.) respectively. The results indicated that the tested phenols are the efficient scavengers Of CO(3)(.-) and NO(2)(.).
出版地ESCHBORN
学科领域Pharmacology & Pharmacy ; Chemistry
作者部门Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Peoples R China;
Chinese Acad Sci, Shanghai Inst Nucl Res, Lab Radiat Chem, Shanghai, Peoples R China;
Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China;
Univ Paris 07, Inst Topol & Dynam Syst, Paris, France
文章类型Article
收录类别SCIE ; PubMed ; MEDLINE
语种英语
WOS记录号WOS:000186193400013
PM记录号14609289
第一机构
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文献类型期刊论文
条目标识符http://ir.lzu.edu.cn/handle/262010/115692
Collection生命科学学院
通讯作者Zheng, RL (reprint author), Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Peoples R China.
Recommended Citation:
GB/T 7714
Zhao, CY,Shi, YM,Yao, SD,et al. Scavenging effects of natural phenols on oxidizing intermediates of peroxynitrite[J]. PHARMAZIE,2003,58(10):742-749.
APA Zhao, CY.,Shi, YM.,Yao, SD.,Jia, ZJ.,Fan, BT.,...&Zheng, RL .(2003).Scavenging effects of natural phenols on oxidizing intermediates of peroxynitrite.PHARMAZIE,58(10),742-749.
MLA Zhao, CY,et al."Scavenging effects of natural phenols on oxidizing intermediates of peroxynitrite".PHARMAZIE 58.10(2003):742-749.
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