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题名: Synthesis and DNA-binding ability of Sp1 protein zinc finger domain and its peptidomimetics
作者: Wang, R(王锐); Ni, JM(倪京满); Hu, XY; Ma, YP; Li, XQ; Yang, DJ; Dong, SL(董守良); Yang, XW; Pan, XF(潘鑫复)
收录类别: SCIE ; PubMed ; BIOSIS
出版日期: 1997-10
刊名: SCIENCE IN CHINA SERIES C-LIFE SCIENCES
卷号: 40, 期号:5, 页码:518-523
期刊主办单位: 中国科学院
出版者: SCIENCE CHINA PRESS
出版地: BEIJING
英文摘要: The second zinc finger fragment of Sp1 (Sp1-ZF2), its mutant (Sp1-ZF2/HT. E-20 --> H, R-23 --> T), and two mimic analogues (ZF20 and ZF15) were synthesized by stepwise solid phase technique. The CD spectra and UV-visible spectrum with CoCl2 indicated that the formation of zinc finger structure was affected not only by the hydrophobic amino acids but also by the change of the distance between Cys and His. Gel-retardation electrophoresis assays indicated that the Glu and Arg residues are very important for recognition. A single zinc finger like Sp1-ZF2 is able to bind DNA sequence specifically.
关键词: zinc finger domain ; Sp1 protein ; solid phase peptide synthesis ; sequence specifically oligonucleotide
作者部门: LANZHOU UNIV,DEPT BIOL,STATE KEY LAB APPL ORGAN CHEM,LANZHOU 730000,PEOPLES R CHINA
学科分类: Life Sciences & Biomedicine - Other Topics
文章类型: Article
语种: 英语
ISSN号: 1006-9305
WOS记录号: WOS:A1997XU77200011
PM记录号: 20229304
BIOSIS记录号: BCI:BCI199800071025
IR记录号: BCI:BCI199800071025
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/116008
Appears in Collections:生命科学学院_期刊论文

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Recommended Citation:
Wang, R,Ni, JM,Hu, XY,et al. Synthesis and DNA-binding ability of Sp1 protein zinc finger domain and its peptidomimetics[J]. SCIENCE IN CHINA SERIES C-LIFE SCIENCES,1997,40(5):518-523.
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