| Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer's disease |
| Xu, CL(许存禄) ; Wang, ZH; Fan, M; Liu, B; Song, M; Zhen, XT; Jiang, TZ; Jiang, TZ (reprint author), Chinese Acad Sci, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Inst Automat, Beijing 100190, Peoples R China. |
| 2010-08-23
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Source Publication | NEUROREPORT
 |
ISSN | 0959-4965
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Volume | 21Issue:12Pages:802-807 |
Abstract | Earlier studies showed that the Val66Met polymorphisms of the brain-derived neurotrophic factor differentially affect gray matter volume and brain region activities. This study used resting positron emission tomography to investigate the relationship between the polymorphisms of Val66Met and the regional cerebral metabolic rate in the brain. We analyzed the positron emission tomography images of 215 patients from the Alzheimer's Disease Neuroimaging Initiative and found significant differences in the parahippocampal gyrus, superior temporal gyrus, prefrontal cortex, and inferior parietal lobule when comparing Met carriers with noncarriers among both the normal controls and those with mild cognitive impairment. For those with Alzheimer's disease, we also found additional differences in the bilateral insula between the carriers and noncarriers. NeuroReport 21:802-807 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins. |
Keyword | Alzheimer's disease
brain-derived neurotrophic factor
cerebral metabolic rate for glucose
polymorphism
positron emission tomography
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Subject Area | Neurosciences & Neurology
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Publisher | LIPPINCOTT WILLIAMS & WILKINS
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DOI | 10.1097/WNR.0b013e32833ccaf4
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Publication Place | PHILADELPHIA
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Indexed By | SCIE
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Language | 英语
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First Inst | 否
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Funding Project | 国家自然科学基金项目
; 国家重点基础研究发展计划以及国家重大科学研究计划(973计划)
; 美国国立卫生研究院项目
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Project Number | National Key Basic Research and Development Program (973) [2007CB512305]
; National Natural Science Foundation of China [60903101]
; Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health) [U01 AG024904]
; National Institute on Aging
; National Institute of Biomedical Imaging and Bioengineering
; National Institutes of Health [P30 AG010129, K01 AG030514]
; Dana Foundation
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WOS ID | WOS:000280592900002
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Funding Organization | NSFC
; MOST
; NIH
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Subtype | Article
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Department | [Xu, Cunlu;Wang, Zhenhua;Fan, Ming;Liu, Bing;Song, Ming;Jiang, Tianzi] Chinese Acad Sci, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Inst Automat, Beijing 100190, Peoples R China;[Xu, Cunlu;Wang, Zhenhua;Zhen, Xiantong] Lanzhou Univ, Sch Informat Sci & Engn, Lanzhou 730000, Peoples R China |
Citation statistics |
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Document Type | 期刊论文
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Identifier | http://ir.lzu.edu.cn/handle/262010/116163
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Collection | 信息科学与工程学院
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Corresponding Author | Jiang, TZ (reprint author), Chinese Acad Sci, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Inst Automat, Beijing 100190, Peoples R China. |
Recommended Citation GB/T 7714 |
Xu, CL,Wang, ZH,Fan, M,et al. Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer's disease[J].
NEUROREPORT,2010,21(12):802-807.
|
APA |
Xu, CL.,Wang, ZH.,Fan, M.,Liu, B.,Song, M.,...&Jiang, TZ .(2010).Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer's disease.NEUROREPORT,21(12),802-807.
|
MLA |
Xu, CL,et al."Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer's disease".NEUROREPORT 21.12(2010):802-807.
|
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