Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer's disease

doi:10.1097/WNR.0b013e32833ccaf4

	Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer's disease
	Xu, CL(许存禄); Wang, ZH; Fan, M; Liu, B; Song, M; Zhen, XT; Jiang, TZ; Jiang, TZ (reprint author), Chinese Acad Sci, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Inst Automat, Beijing 100190, Peoples R China.
	2010-08-23
Source Publication	NEUROREPORT
ISSN	0959-4965
Volume	21 Issue:12 Pages:802-807
Abstract	Earlier studies showed that the Val66Met polymorphisms of the brain-derived neurotrophic factor differentially affect gray matter volume and brain region activities. This study used resting positron emission tomography to investigate the relationship between the polymorphisms of Val66Met and the regional cerebral metabolic rate in the brain. We analyzed the positron emission tomography images of 215 patients from the Alzheimer's Disease Neuroimaging Initiative and found significant differences in the parahippocampal gyrus, superior temporal gyrus, prefrontal cortex, and inferior parietal lobule when comparing Met carriers with noncarriers among both the normal controls and those with mild cognitive impairment. For those with Alzheimer's disease, we also found additional differences in the bilateral insula between the carriers and noncarriers. NeuroReport 21:802-807 (C) 2010 Wolters Kluwer Health \| Lippincott Williams & Wilkins.
Keyword	Alzheimer's disease brain-derived neurotrophic factor cerebral metabolic rate for glucose polymorphism positron emission tomography
Subject Area	Neurosciences & Neurology
Publisher	LIPPINCOTT WILLIAMS & WILKINS
DOI	10.1097/WNR.0b013e32833ccaf4
Publication Place	PHILADELPHIA
Indexed By	SCIE
Language	英语
First Inst	否
Funding Project	国家自然科学基金项目 ; 国家重点基础研究发展计划以及国家重大科学研究计划（973计划） ; 美国国立卫生研究院项目
Project Number	National Key Basic Research and Development Program (973) [2007CB512305] ; National Natural Science Foundation of China [60903101] ; Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health) [U01 AG024904] ; National Institute on Aging ; National Institute of Biomedical Imaging and Bioengineering ; National Institutes of Health [P30 AG010129, K01 AG030514] ; Dana Foundation
WOS ID	WOS:000280592900002
Funding Organization	NSFC ; MOST ; NIH
Subtype	Article
Department	[Xu, Cunlu; Wang, Zhenhua; Fan, Ming; Liu, Bing; Song, Ming; Jiang, Tianzi] Chinese Acad Sci, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Inst Automat, Beijing 100190, Peoples R China; [Xu, Cunlu; Wang, Zhenhua; Zhen, Xiantong] Lanzhou Univ, Sch Informat Sci & Engn, Lanzhou 730000, Peoples R China
Citation statistics	Cited Times:15[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.lzu.edu.cn/handle/262010/116163
Collection	信息科学与工程学院
Corresponding Author	Jiang, TZ (reprint author), Chinese Acad Sci, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Inst Automat, Beijing 100190, Peoples R China.
Recommended Citation GB/T 7714	Xu, CL,Wang, ZH,Fan, M,et al. Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer's disease[J]. NEUROREPORT,2010,21(12):802-807.
APA	Xu, CL.,Wang, ZH.,Fan, M.,Liu, B.,Song, M.,...&Jiang, TZ .(2010).Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer's disease.NEUROREPORT,21(12),802-807.
MLA	Xu, CL,et al."Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer's disease".NEUROREPORT 21.12(2010):802-807.

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