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题名: Ontology driven decision support for the diagnosis of mild cognitive impairment
作者: Zhang, XW; Hu, B(胡斌); Ma, X; Moore, P; Chen, J
收录类别: SCIE ; EI ; PubMed ; MEDLINE
出版日期: 2014-03
刊名: COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
卷号: 113, 期号:3, 页码:781-791
出版者: ELSEVIER
出版地: CLARE
英文摘要: In recent years, mild cognitive impairment (MCI) has attracted significant attention as an indicator of high risk for Alzheimer's disease (AD), and the diagnosis of MCI can alert patient to carry out appropriate strategies to prevent AD. To avoid subjectivity in diagnosis, we propose an ontology driven decision support method which is an automated procedure for diagnosing MCI through magnetic resonance imaging (MRI). In this approach, we encode specialized MRI knowledge into an ontology and construct a rule set using machine learning algorithms. Then we apply these two parts in conjunction with reasoning engine to automatically distinguish MCI patients from normal controls (NC). The rule set is trained by MRI data of 187 MCI patients and 177 normal controls selected from Alzheimer's Disease Neuroimaging Initiative (ADNI) using C4.5 algorithm. By using a 10-fold cross validation, we prove that the performance of C4.5 with 80.2% sensitivity is better than other algorithms, such as support vector machine (SVM), Bayesian network (BN) and back propagation (BP) neural networks, and C4.5 is suitable for the construction of reasoning rules. Meanwhile, the evaluation results suggest that our approach would be useful to assist physicians efficiently in real clinical diagnosis for the disease of MCI. (c) 2014 Elsevier Ireland Ltd. All rights reserved.
关键词: Alzheimer dementia ; Mild cognitive impairment ; Diagnosis ; Ontology ; Magnetic resonance imaging (MRI) ; Decision tree
作者部门: [Zhang, Xiaowei ; Hu, Bin ; Ma, Xu ; Chen, Jing] Lanzhou Univ, Sch Informat Sci & Engn, Lanzhou 730000, Peoples R China ; [Hu, Bin] Beijing Univ Technol, Coll Elect Informat & Control Engn, Beijing, Peoples R China ; [Hu, Bin ; Moore, Philip] Birmingham City Univ, Sch Comp Telecommun & Networks, Birmingham, W Midlands, England
通讯作者: Hu, B (reprint author), Beijing Univ Technol, Coll Elect Informat & Control Engn, Beijing, Peoples R China.
学科分类: Computer Science; Engineering; Medical Informatics
文章类型: Article
所属项目编号: National Basic Research Program of China (973 Program) [2014CB744600, 2011CB711000] ; National Natural Science Foundation of China [61210010] ; International Cooperation Project of Ministry of Science and Technology [2013DFA11140] ; Gansu Provincial Science & Technology Department [1208RJYA015]
所属项目名称: 国家自然科学基金项目 ; 国家重点基础研究发展计划以及国家重大科学研究计划(973计划) ; 国家国际科技合作专项 ; 甘肃省青年科技基金计划
项目资助者: NSFC ; MOST ; GSSTD
语种: 英语
DOI: 10.1016/j.cmpb.2013.12.073
ISSN号: 0169-2607
WOS记录号: WOS:000331726500007
EI记录号: 20140917386931
PM记录号: 24468160
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/116263
Appears in Collections:信息科学与工程学院_期刊论文

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Recommended Citation:
Zhang, XW,Hu, B,Ma, X,et al. Ontology driven decision support for the diagnosis of mild cognitive impairment[J]. COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE,2014,113(3):781-791.
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