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题名: Interaction of DNA with aromatic hydrocarbons fraction in atmospheric particulates of Xigu District of Lanzhou, China
作者: Gao, H; Ma, MQ; Zhou, L; Jia, RP; Chen, XG(陈兴国); Hu, ZD(胡之德)
收录类别: SCIE ; EI ; PubMed ; MEDLINE ; BIOSIS ; CSCD
出版日期: 2007
刊名: JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA
卷号: 19, 期号:8, 页码:948-954
期刊主办单位: 中国科学院生态环境研究中心
出版者: SCIENCE CHINA PRESS
出版地: BEIJING
英文摘要: Voluminously epidemiological studies show that the relationships exist between the air pollution and human health and cancer. Aromatic hydrocarbons (AHs) in air form a large class of organic pollutants, which are widely in environment and many of them are known to be carcinogenic and/or mutagenic and contribute to ambient air pollution. In the past decades, bioassays mainly have been used to evaluate the toxicity of chemical mixtures in atmospheric particulates or aqueous environment. However, it is well known that the covalent complexes formed by carcinogens with DNA may be exert negative results in bioassay. So the main aim of this paper is to develop an evaluation method of toxicity effects of chemical mixtures in atmospheric particulates from chemical standpoint. In this study, the in vitro interaction of the AHs with DNA was investigated by absorption, fluorescence and resonance light scattering (RLS) spectroscopic techniques. The results showed that the AHs in the atmospheric particulates could combine with calf thymus DNA (ctDNA) and herring sperm DNA (hsDNA) without being activated or metabolized by organism, respectively. Intercalation may be present in the mechanism of interaction. The binding constants of the AHs with ctDNA and hsDNA were 2.5x10(2) and 2.0x10(3), respectively, which indicated that the interaction of the AHs with hsDNA is stronger than that with ctDNA. In addition, the relationships of dose-effect between the total mole concentration of chemical components and the ability of binding ctDNA and hsDNA were confirmed. This research made it possible to study the toxicity effects of chemical mixtures in atmospheric particulates by chemical method. It is believed that the composition and contents of unknown AHs and the interaction of DNA with AHs in atmospheric particulates of Xigu District of Lanzhou City, China are first reported in the past twenty years.
关键词: atmospheric particulates ; aromatic hydrocarbons fraction ; interaction with DNA
作者部门: Lanzhou Univ, Coll Earth & Environm Sci, Minist Educ, Key Lab Western Chinas Environm Syst, Lanzhou 730000, Peoples R China ; Lanzhou Enviornm Monitoring Stn, Lanzhou 730000, Peoples R China ; Lanzhou Univ, Dept Chem, Lanzhou 730000, Peoples R China
通讯作者: Gao, H (reprint author), Lanzhou Univ, Coll Earth & Environm Sci, Minist Educ, Key Lab Western Chinas Environm Syst, Lanzhou 730000, Peoples R China.
学科分类: Environmental Sciences & Ecology
文章类型: Article
语种: 英语
DOI: 10.1016/S1001-0742(07)60156-9
ISSN号: 1001-0742
WOS记录号: WOS:000248736600008
CSCD记录号: CSCD:2855199
EI记录号: 20073310764270
PM记录号: 17966851
BIOSIS记录号: BIOSIS:PREV200700541131
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/119744
Appears in Collections:资源环境学院_期刊论文

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Recommended Citation:
Gao, H,Ma, MQ,Zhou, L,et al. Interaction of DNA with aromatic hydrocarbons fraction in atmospheric particulates of Xigu District of Lanzhou, China[J]. JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA,2007,19(8):948-954.
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