兰州大学机构库 >基础医学院
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Endomorphin-1 analogs containing alpha-methyl-beta-amino acids exhibit potent analgesic activity after peripheral administration 期刊论文
ORGANIC & BIOMOLECULAR CHEMISTRY, 2017, 卷号: 12, 期号: 23, 页码: 4951-4955
Authors:  Wang, Y;  Yang, JX;  Liu, X;  Zhao, L;  Yang, DX;  Zhou, JJ;  Wang, D;  Mou, LY;  Wang, R(王锐);  Wang, R (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Dept Pharmacol, Inst Biochem & Mol Biol,Sch Basic Med Sci, Lanzhou 730000, Peoples R China....Wang, Y;  Yang, JX;  Liu, X;  Zhao, L;  Yang, DX;  Zhou, JJ;  Wang, D;  Mou, LY;  Wang, R(王锐);  Wang, R (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Dept Pharmacol, Inst Biochem & Mol Biol,Sch Basic Med Sci, Lanzhou 730000, Peoples R China.
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Magnesium Catalysis Mediated Tetrazoles in Desymmetrization Reaction of Aziridines 期刊论文
ORGANIC LETTERS, 2017, 卷号: 19, 期号: 12, 页码: 3211-3214
Authors:  Li, D;  Wang, KZ;  Wang, LQ;  Wang, Y;  Wang, PX;  Liu, X;  Yang, DX;  Wang, R(王锐);  Wang, R (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China.
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Asymmetric synthesis of CF3-containing tetrahydroquinoline via a thiourea-catalyzed cascade reaction 期刊论文
ORGANIC & BIOMOLECULAR CHEMISTRY, 2017, 卷号: 15, 期号: 21, 页码: 4544-4547
Authors:  Zhu, YY;  Li, BY;  Wang, C;  Dong, ZH;  Zhong, XL;  Wang, KR;  Yan, WJ;  Wang, R(王锐);  Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Inst Pharmacol, Lanzhou 730000, Peoples R China.;  Wang, R (reprint author), Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China....Zhu, YY;  Li, BY;  Wang, C;  Dong, ZH;  Zhong, XL;  Wang, KR;  Yan, WJ;  Wang, R(王锐);  Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Inst Pharmacol, Lanzhou 730000, Peoples R China.;  Wang, R (reprint author), Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China.
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An Efficient Nickel-Catalyzed Asymmetric Oxazole-Forming Ugi-Type Reaction for the Synthesis of Chiral Aryl-Substituted THIQ Rings 期刊论文
CHEMISTRY-A EUROPEAN JOURNAL, 2017, 卷号: 23, 期号: 29, 页码: 6974-6978
Authors:  Li, D;  Yang, DX;  Wang, LQ;  Liu, XH;  Wang, KZ;  Wang, J;  Wang, PX;  Liu, YY;  Zhu, HY;  Wang, R(王锐)...Li, D;  Yang, DX;  Wang, LQ;  Liu, XH;  Wang, KZ;  Wang, J;  Wang, PX;  Liu, YY;  Zhu, HY;  Wang, R(王锐);  Wang, R (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China.;  Wang, R (reprint author), Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, State Key Lab Chirosci, Kowloon, Hong Kong, Peoples R China.
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chirality  nickel  oxazole  tetrahydroquinoline  ugi reaction  
Regio- and stereoselective ring-opening reaction of spiro-epoxyoxindoles with ammonia under catalyst-free conditions 期刊论文
GREEN CHEMISTRY, 2017, 卷号: 19, 期号: 9, 页码: 2107-2110
Authors:  Zhang, BZ;  Li, YP;  Bao, GJ;  Zhu, GM;  Li, J;  Wang, JL;  Zhang, B;  Sun, WS(孙旺盛);  Hong, L;  Wang, R(王锐)...Zhang, BZ;  Li, YP;  Bao, GJ;  Zhu, GM;  Li, J;  Wang, JL;  Zhang, B;  Sun, WS(孙旺盛);  Hong, L;  Wang, R(王锐);  Wang, R (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Sch Life Sci, Lanzhou 730000, Peoples R China.;  Hong, L (reprint author), Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China.
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Efficient Catalytic Kinetic Resolution of Spiro-epoxyoxindoles with Concomitant Asymmetric Friedel-Crafts Alkylation of Indoles 期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2017, 卷号: 56, 期号: 19, 页码: 5332-5335
Authors:  Zhu, GM;  Bao, GJ;  Li, YP;  Sun, WS(孙旺盛);  Li, J;  Hong, L;  Wang, R(王锐);  Hong, L (reprint author), Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China.;  Wang, R (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China.
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asymmetric catalysis  alkylation  kinetic resolution  organocatalysis  spiro-compounds  
Antimicrobial activity and stability of protonectin with D-amino acid substitutions 期刊论文
JOURNAL OF PEPTIDE SCIENCE, 2017, 卷号: 23, 期号: 5, 页码: 392-402
Authors:  Qiu, S;  Zhu, RR;  Zhao, YY;  An, XP;  Jia, FJ;  Peng, JX;  Ma, ZL;  Zhu, YY;  Wang, JY;  Su, JH...Qiu, S;  Zhu, RR;  Zhao, YY;  An, XP;  Jia, FJ;  Peng, JX;  Ma, ZL;  Zhu, YY;  Wang, JY;  Su, JH;  Wang, QJ;  Wang, HL;  Li, Y;  Wang, KR;  Yan, WJ;  Wang, R(王锐);  Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Lanzhou, Peoples R China.
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antimicrobial peptides  protonectin  stability  D-amino acid substitution  
Structure-constrained endomorphin analogs display differential antinociceptive mechanisms in mice after spinal administration 期刊论文
PEPTIDES, 2017, 卷号: 91, 页码: 40-48
Authors:  Wang, Y;  Zhou, JJ;  Liu, X;  Zhao, L;  Wang, ZJ;  Zhang, XH;  Wang, KZ;  Wang, LQ;  Wang, R(王锐);  Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, 199 Donggang West Rd, Lanzhou 730000, Peoples R China....Wang, Y;  Zhou, JJ;  Liu, X;  Zhao, L;  Wang, ZJ;  Zhang, XH;  Wang, KZ;  Wang, LQ;  Wang, R(王锐);  Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, 199 Donggang West Rd, Lanzhou 730000, Peoples R China.
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Spinal antinociception  Endomorphin  Dynorphin  Antagonist  Antibody  
Asymmetric Synthesis of alpha-Trifluoromethyl Pyrrolidines through Organocatalyzed 1,3-Dipolar Cycloaddition Reaction 期刊论文
JOURNAL OF ORGANIC CHEMISTRY, 2017, 卷号: 82, 期号: 7, 页码: 3482-3490
Authors:  Dong, ZH;  Zhu, YY;  Li, BY;  Wang, C;  Yan, WJ;  Wang, KR;  Wang, R(王锐);  Wang, R (reprint author), Lanzhou Univ, Inst Pharmacol, Key Lab Preclin Study New Drugs Gansu Prov, Sch Basic,Med Sci, Lanzhou 730000, Peoples R China.;  Wang, R (reprint author), Chinese Acad Sci, State Key Lab Oxo Synth & Select Oxidat, Lanzhou Inst Chem Phys, Lanzhou 730000, Peoples R China.
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Design of novel antimicrobial peptide dimer analogues with enhanced antimicrobial activity in vitro and in vivo by intermolecular triazole bridge strategy 期刊论文
PEPTIDES, 2017, 卷号: 88, 页码: 115-125
Authors:  Liu, BJ;  Huang, HF;  Yang, ZB;  Liu, BY;  Gou, SH;  Zhong, C;  Han, XF;  Zhang, Y;  Ni, JM;  Wang, R(王锐)...Liu, BJ;  Huang, HF;  Yang, ZB;  Liu, BY;  Gou, SH;  Zhong, C;  Han, XF;  Zhang, Y;  Ni, JM;  Wang, R(王锐);  Liu, BJ (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China.;  Liu, BJ (reprint author), Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China.
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Click chemistry  Dimer analogues  Antimicrobial activity  alpha Helical structure  Drug resistance