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题名: Differential mechanisms involved in effects of genistein and 17-beta-estradiol on porcine coronary arteries
作者: Li, HF(李红芳); Zhang, P; Tian, ZF; Qiu, XQ; Zhang, YF; Wu, JX; Jia, ZJ(贾忠建)
收录类别: SCIE ; MEDLINE ; BIOSIS
出版日期: 2006-05
刊名: PHARMAZIE
卷号: 61, 期号:5, 页码:461-465
英文摘要: The purpose of this work was to examine the differential mechanisms involved in relaxation induced by genistein and 17-beta-estradiol in isolated porcine coronary arteries. Similar to 17-beta-estradiol, genistein could dose-dependently relax 30 mM KCI-precontracted coronary artery rings. The pD(2) values of genistein and 17-beta-estradiol were 4.91 +/- 0.13 and 4.98 +/- 0.12 respectively. Incubation with N-L-nitroarginine (L-NNA), endothelium removal or in the presence of a potent inhibitor of protein tyrosine phosphatase sodium orthovanadate did not affect the relaxation induced by genistein, but could partially reduce the vasorelaxation induced by 17-beta-estradiol. The relaxations induced by genistein and 17-beta-estradiol were unaffected by the estrogen receptor antagonist tamoxifen, the inhibitor of prostanoid synthesis indomethacin and the protein synthesis inhibitor, cycloheximide. In addition, both of genistein and 17-beta-estradiol could decrease the contractile responses of KCI, 5-HT and CaCl2, and shift their cumulative concentration-response curves rightward in a parallel manner. These findings suggest that the relaxant effects induced by genistein and 17-beta-estradiol are probably mainly due to inhibition of Ca2+ influx through voltage-dependent calcium channels (VDCCs), and are not related to sex hormone receptor and classical genomic activities. Also there is an interesting finding that the relaxing response of 17-beta-estradiol is partially endothelium-dependent, but that of genistein is not.
作者部门: Lanzhou Univ, Coll Basic Sci, Dept Physiol, Funct Lab Med, Lanzhou 730000, Peoples R China ; Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou, Peoples R China ; Lanzhou Univ, Natl Lab Appl Organ Chem, Lanzhou, Peoples R China
通讯作者: Li, HF (reprint author), Lanzhou Univ, Coll Basic Sci, Dept Physiol, Funct Lab Med, Lanzhou 730000, Peoples R China.
学科分类: Pharmacology & Pharmacy; Chemistry
文章类型: Article
语种: 英语
ISSN号: 0031-7144
WOS记录号: WOS:000237635200017
PM记录号: 16724547
BIOSIS记录号: BIOSIS:PREV200600457191
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/121355
Appears in Collections:基础医学院_期刊论文

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