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题名: Effects of phytoestrogens and 17 beta-estradiol on vasoconstriction elicited by reactive oxygen species
作者: Zhang, P; Li, HF(李红芳); Tian, ZF; Qiu, XQ; Wu, JX; Jia, ZJ(贾忠建)
收录类别: SCIE ; MEDLINE ; BIOSIS
出版日期: 2007-05
刊名: PHARMAZIE
卷号: 62, 期号:5, 页码:378-381
英文摘要: To study the effects of different reactive oxygen species (ROS) on the resting tension of porcine coronary artery rings and to identify the effects of genistein (GEN), resveratrol (RES) and 17 beta-estradiol (EST) on ROS-elicited vasoconstriction, porcine coronary rings were prepared and mounted in an organ bath and, after an equilibration period, the changes induced by the drugs were observed. Rings with intact endothelium showed an obvious but slow contraction after treatment with xanthine (100 mu M)/xanthine oxidase (20 mU . mL(-1)) (X/XO) whereas endothelium-denuded rings showed no effects. H2O2 (200 mu M) induced a fast and transient contraction in endothelium-denuded rings and failed to do so in intact-endothelium rings. Like superoxide dismutase (SOD, 200 U . mL(-1)), GEN (1 mu M) and RES (1 mu M) significantly inhibited contractile response evoked by X/XO, however in contrast to GEN and RES, EST (1 mu M) had no obvious effect. GEN (30 mu M) and RES (30 mu M), like catalase (CAT, 800 U . mL(-1)), markedly attenuated the contraction elicited by H2O2. The results demonstrate that GEN and RES have distinct inhibitory effects on vasoconstriction induced by O-2(center dot-) generated by X/XO and H2O2, and their actions are clearly greater than to that of EST.
作者部门: Lanzhou Univ, Dept Physiol, Coll Basic Med, Lanzhou 730000, Peoples R China
通讯作者: Li, HF (reprint author), Lanzhou Univ, Dept Physiol, Coll Basic Med, 199 Donggang W Rd, Lanzhou 730000, Peoples R China.
学科分类: Pharmacology & Pharmacy; Chemistry
文章类型: Article
语种: 英语
DOI: 10.1691/ph.2007.5.5649
ISSN号: 0031-7144
WOS记录号: WOS:000246641100012
PM记录号: 17557748
BIOSIS记录号: BIOSIS:PREV200700405201
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/121364
Appears in Collections:基础医学院_期刊论文

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