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题名: RNF168 forms a functional complex with RAD6 during the DNA damage response
作者: Liu, C; Wang, DG; Wu, JX; Keller, J; Ma, T; Yu, XC
收录类别: SCIE
出版日期: 2013-05-01
刊名: JOURNAL OF CELL SCIENCE
卷号: 126, 期号:9, 页码:2042-2051
出版者: COMPANY OF BIOLOGISTS LTD
出版地: CAMBRIDGE
英文摘要: Protein ubiquitination plays an important role in initiating the DNA damage response. Following DNA damage, E2 ubiquitin conjugating enzymes are crucial for catalyzing substrate ubiquitination that recruits downstream DNA repair factors to DNA lesions. To identify novel E2 conjugating enzymes important for initiating the DNA-damage-induced ubiquitination cascade, we screened most of the known E2 enzymes and found that RAD6A and RAD6B function together with RNF168 in the ionizing radiation (IR)-induced DNA damage response. Similarly to RNF168-deficient cells, RAD6A- or RAD6B-deficient cells exhibit a reduction in DNA-damage-induced protein ubiquitination. Correspondingly, DNA-damage-induced foci formation of DNA damage repair proteins, such as BRCA1 and 53BP1, is impaired in the absence of RAD6A or RAD6B. Moreover, the RNF168-RAD6 complex targeted histone H1.2 for ubiquitination in vitro and regulated DNA-damage-induced histone H1.2 ubiquitination in vivo. Collectively, these data demonstrate that RNF168, in complex with RAD6A or RAD6B, is activated in the DNA-damage-induced protein ubiquitination cascade.
关键词: RAD6 ; RNF168 ; Ubiquitination ; DNA damage response
作者部门: [Liu, Chao] Fudan Univ, Inst Genet, Sch Life Sci, State Key Lab Genet Engn, Shanghai 200433, Peoples R China ; [Liu, Chao ; Wang, Degui ; Wu, Jiaxue ; Keller, Jennifer ; Ma, Teng ; Yu, Xiaochun] Univ Michigan, Sch Med, Dept Internal Med, Div Mol Med & Genet, Ann Arbor, MI 48109 USA ; [Wang, Degui] Lanzhou Univ, Sch Basic Med Sci, Dept Anat & Histol, Lanzhou 730000, Peoples R China
通讯作者: Yu, XC (reprint author), Univ Michigan, Sch Med, Dept Internal Med, Div Mol Med & Genet, Ann Arbor, MI 48109 USA.
学科分类: Cell Biology
文章类型: Article
所属项目编号: National Institutes of Health [CA132755, CA130899] ; National Natural Science Foundation of China [81171954] ; Department of Defense
所属项目名称: 国家自然科学基金项目 ; 美国国立卫生研究院项目
项目资助者: NSFC ; NIH
语种: 英语
DOI: 10.1242/jcs.122945
ISSN号: 0021-9533
WOS记录号: WOS:000319561700015
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/121626
Appears in Collections:基础医学院_期刊论文

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Recommended Citation:
Liu, C,Wang, DG,Wu, JX,et al. RNF168 forms a functional complex with RAD6 during the DNA damage response[J]. JOURNAL OF CELL SCIENCE,2013,126(9):2042-2051.
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