兰州大学机构库 >基础医学院
Whole Brain Radiotherapy Combined with Stereotactic Radiotherapy Versus Stereotactic Radiotherapy Alone for Brain Metastases: a Meta-analysis
Duan, L; Zeng, R; Yang, KH(杨克虎); Tian, JH(田金徽); Wu, XL; Dai, Q; Niu, XD; Ma, DW; Yang, KH (reprint author), Lanzhou Univ, Evidence Based Med Ctr, Lanzhou 730000, Peoples R China.
Indexed BySCIE ; PubMed ; MEDLINE
2014
Source PublicationASIAN PACIFIC JOURNAL OF CANCER PREVENTION
ISSN1513-7368
Volume15Issue:2Pages:911-915
AbstractAim: This study was to evaluate the effect of whole brain radiation (WBRT) combined with stereotactic radiotherapy (SRS) versus stereotactic radiotherapy alone for patients with brain metastases using a meta-analysis. Materials and Methods: We searched PubMed, EMBASE, Cochrane Library from their inception up to October 2013. Randomized controlled trials involving whole brain radiation combined with stereotactic radiotherapy versus stereotactic radiotherapy alone for brain metastases were included. Statistical analyses were performed using RevMan5.2 software. Results: Four randomized controlled trials including 903 patients were included. The meta-analysis showed statistically significant lowering of the local recurrence rate (OR=0.29, 95% CI: 0.17 similar to 0.49), new brain metastasis rate (OR=0.45, 95% CI: 0.28 similar to 0.71) and symptomatic late neurologic radiation toxicity rate (OR=3.92, 95% CI: 1.37 similar to 11.20) in the combined group. No statistically significant difference existed in the 1-year survival rate (OR=0.78, 95% CI: 0.60 similar to 1.03). Conclusions: The results indicate that whole brain radiotherapy combined with stereotactic radiotherapy has advantages in local recurrence and new brain metastasis rates, but stereotactic radiotherapy alone is associated with better neurological function. However, as the samples included were not large, more high-quality, large-sample size studies are necessary for confirmation.
KeywordBrain metastases whole brain radiation stereotactic radiotherapy meta-analysis
Subject AreaOncology
PublisherASIAN PACIFIC ORGANIZATION CANCER PREVENTION
Publication PlaceGYEONGGI-DO
DOI10.7314/APJCP.2014.15.2.911
First Inst
Language英语
SubtypeArticle
WOS IDWOS:000332517500065
PMID 24568518
Department
[Duan, Lei;
Zeng, Rong;
Yang, Ke-Hu;
Tian, Jin-Hui] Lanzhou Univ, Evidence Based Med Ctr, Lanzhou 730000, Peoples R China;
[Duan, Lei;
Zeng, Rong;
Wu, Xiao-Lu] Lanzhou Univ, Hosp 2, Lanzhou 730000, Peoples R China;
[Dai, Qiang] Lanzhou Univ, Clin Med Coll 1, Lanzhou 730000, Peoples R China;
[Niu, Xiao-Dong;
Ma, Di-Wa] Lanzhou Univ, Clin Med Coll 2, Lanzhou 730000, Peoples R China...更多
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.lzu.edu.cn/handle/262010/121684
Collection基础医学院
Corresponding AuthorYang, KH (reprint author), Lanzhou Univ, Evidence Based Med Ctr, Lanzhou 730000, Peoples R China.
Recommended Citation
GB/T 7714
Duan, L,Zeng, R,Yang, KH,et al. Whole Brain Radiotherapy Combined with Stereotactic Radiotherapy Versus Stereotactic Radiotherapy Alone for Brain Metastases: a Meta-analysis[J]. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,2014,15(2):911-915.
APA Duan, L.,Zeng, R.,Yang, KH.,Tian, JH.,Wu, XL.,...&Yang, KH .(2014).Whole Brain Radiotherapy Combined with Stereotactic Radiotherapy Versus Stereotactic Radiotherapy Alone for Brain Metastases: a Meta-analysis.ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,15(2),911-915.
MLA Duan, L,et al."Whole Brain Radiotherapy Combined with Stereotactic Radiotherapy Versus Stereotactic Radiotherapy Alone for Brain Metastases: a Meta-analysis".ASIAN PACIFIC JOURNAL OF CANCER PREVENTION 15.2(2014):911-915.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Altmetrics Score
Google Scholar
Similar articles in Google Scholar
[Duan, L]'s Articles
[Zeng, R]'s Articles
[Yang, KH]'s Articles
Baidu academic
Similar articles in Baidu academic
[Duan, L]'s Articles
[Zeng, R]'s Articles
[Yang, KH]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Duan, L]'s Articles
[Zeng, R]'s Articles
[Yang, KH]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Whole Brain Radiotherapy Combined with Stereotactic Radiotherapy Versus Stereotactic Radiotherapy Alone for Brain Metastases_ a Meta-analysis.pdf
Format: Adobe PDF
No comment.
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.