兰州大学机构库 >基础医学院
Insulin Resistance Reduces Sensitivity to Cis-Platinum and Promotes Adhesion, Migration and Invasion in HepG2 Cells
Li, LJ; Li, GD; Wei, HL(魏虎来); Chen, J; Liu, YM; Li, F; Xie, B(谢蓓); Wang, B; Li, CL; Wei, HL (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China.
Indexed BySCIE ; PubMed ; MEDLINE
2014
Source PublicationASIAN PACIFIC JOURNAL OF CANCER PREVENTION
ISSN1513-7368
Volume15Issue:7Pages:3123-3128
AbstractThe liver is normally the major site of glucose metabolism in intact organisms and the most important target organ for the action of insulin. It has been widely accepted that insulin resistance (IR) is closely associated with postoperative recurrence of hepatocellular carcinoma (HCC). However, the relationship between IR and drug resistance in liver cancer cells is unclear. In the present study, IR was induced in HepG2 cells via incubation with a high concentration of insulin. Once the insulin-resistant cell line was established, the stability of HepG2/IR cells was further tested via incubation in insulin-free medium for another 72h. Afterwards, the biological effects of insulin resistance on adhesion, migration, invasion and sensitivity to cis-platinum (DDP) of cells were determined. The results indicated that glucose consumption was reduced in insulin-resistant cells. In addition, the expression of the insulin receptor and glucose transportor-2 was downregulated. Furthermore, HepG2/IR cells displayed markedly enhanced adhesion, migration, and invasion. Most importantly, these cells exhibited a lower sensitivity to DDP. By contrast, HepG2/IR cells exhibited decreased adhesion and invasion after treatment with the insulin sensitizer pioglitazone hydrochloride. The results suggest that IR is closely related to drug resistance as well as adhesion, migration, and invasion in HepG2 cells. These findings may help explain the clinical observation of limited efficacy for chemotherapy on a background of IR, which promotes the invasion and migration of cancer cells.
KeywordHepatocellular carcinoma insulin resistance proliferation pioglitazone hydrochloride
Subject AreaOncology
PublisherASIAN PACIFIC ORGANIZATION CANCER PREVENTION
Publication PlaceGYEONGGI-DO
DOI10.7314/APJCP.2014.15.7.3123
First Inst
Language英语
Project NumberFundamental Research Funds for the Central Universities [lzujbky-2013-142] ; project of youth science and technology fund of Gansu province of China [1308RJYA055] ; Program for Changjiang Scholars and Innovative Research Team in University [PCSIRT: IRT1137]
Funding Project长江学者和创新团队发展计划 ; 中央高校基本科研业务费专项资金 ; 甘肃省青年科技基金计划
Funding OrganizationMOE ; LZU ; GSSTD
SubtypeArticle
WOS IDWOS:000336834500030
PMID 24815457
Department
[Li, Lin-Jing;
Wei, Hu-Lai;
Chen, Jing;
Xie, Bei;
Wang, Bei;
Li, Cai-Li] Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China;
[Li, Lin-Jing;
Li, Guang-Di;
Liu, Yu-Mei;
Li, Fei] Lanzhou Univ, Dept Clin Lab, Hosiptal 2, Lanzhou 730000, Peoples R China...更多
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.lzu.edu.cn/handle/262010/121700
Collection基础医学院
Corresponding AuthorWei, HL (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China.
Recommended Citation
GB/T 7714
Li, LJ,Li, GD,Wei, HL,et al. Insulin Resistance Reduces Sensitivity to Cis-Platinum and Promotes Adhesion, Migration and Invasion in HepG2 Cells[J]. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,2014,15(7):3123-3128.
APA Li, LJ.,Li, GD.,Wei, HL.,Chen, J.,Liu, YM.,...&Wei, HL .(2014).Insulin Resistance Reduces Sensitivity to Cis-Platinum and Promotes Adhesion, Migration and Invasion in HepG2 Cells.ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,15(7),3123-3128.
MLA Li, LJ,et al."Insulin Resistance Reduces Sensitivity to Cis-Platinum and Promotes Adhesion, Migration and Invasion in HepG2 Cells".ASIAN PACIFIC JOURNAL OF CANCER PREVENTION 15.7(2014):3123-3128.
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