兰州大学机构库 >基础医学院
Which is the Best Chinese Herb Injection Based on the FOLFOX Regimen for Gastric Cancer? A Network Meta-analysis of Randomized Controlled Trials
Wang, JC; Tian, JH(田金徽); Ge, L; Gan, YH; Yang, KH(杨克虎); Yang, KH (reprint author), Lanzhou Univ, Evidence Based Med Ctr, Lanzhou 730000, Gansu, Peoples R China.
Indexed BySCIE ; PubMed ; MEDLINE
2014
Source PublicationASIAN PACIFIC JOURNAL OF CANCER PREVENTION
ISSN1513-7368
Volume15Issue:12Pages:4795-4800
AbstractBackground: Few studies have directly compared clinical efficacy and safety among Chinese herb injections (CHIs) for gastric cancer (GC). The present study aimed to compare CHIs combined with FOLFOX regimens for GC to show which provides the best CHIs results. Materials and Methods: 9 electronic databases and 6 gray literature databases were comprehensive searched in April 20, 2013. According to inclusion and exclusion criteria, two reviewers independently selected and assessed the included trials. The risk of bias tool described in the Cochrane Handbook version 5.1.0 and CONSORT statement were used to assess the quality of the trials. All calculations and graphs were performed and produced using ADDIS 1.16.5 software. Results: A total of 541 records were searched and 38 RCTs met the inclusion criteria (2,761 participants), involving 10 CHIs. The results of network meta-analysis showed that compared with FOLFOX alone, combinations with Kanglaite, Astragalus polysaccharides, Cinobufacini, or Yadanziyouru injections could furthest strengthen ORR, improve the quality of life, reduce nausea and vomiting, and reduce the incidence of leukopenia (III-IV). Conclusions: Kanglaite injection, Astragalus polysaccharides injection, Yadanziyouru injection were superior to other CHIs in clinical efficacy and safety for GC. The conclusions now need to be confirmed by large sample size direct head-to-head studies.
KeywordChinese herbs injection gastric cancer FOLFOX network meta-analysis
Subject AreaOncology
PublisherASIAN PACIFIC ORGANIZATION CANCER PREVENTION
Publication PlaceGYEONGGI-DO
DOI10.7314/APJCP.2014.15.12.4795
First Inst
Language英语
SubtypeArticle
WOS IDWOS:000343721800009
PMID 24998543
Department[Wang, Jian-Cheng;
Tian, Jin-Hui;
Gan, Yu-Hong;
Yang, Ke-Hu] Lanzhou Univ, Evidence Based Med Ctr, Lanzhou 730000, Gansu, Peoples R China;
[Yang, Ke-Hu] Lanzhou Univ, Key Lab Evidence Based Med & Knowledge Translat G, Lanzhou 730000, Gansu, Peoples R China;
[Ge, Long] Lanzhou Univ, Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.lzu.edu.cn/handle/262010/121731
Collection基础医学院
Corresponding AuthorYang, KH (reprint author), Lanzhou Univ, Evidence Based Med Ctr, Lanzhou 730000, Gansu, Peoples R China.
Recommended Citation
GB/T 7714
Wang, JC,Tian, JH,Ge, L,et al. Which is the Best Chinese Herb Injection Based on the FOLFOX Regimen for Gastric Cancer? A Network Meta-analysis of Randomized Controlled Trials[J]. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,2014,15(12):4795-4800.
APA Wang, JC,Tian, JH,Ge, L,Gan, YH,Yang, KH,&Yang, KH .(2014).Which is the Best Chinese Herb Injection Based on the FOLFOX Regimen for Gastric Cancer? A Network Meta-analysis of Randomized Controlled Trials.ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,15(12),4795-4800.
MLA Wang, JC,et al."Which is the Best Chinese Herb Injection Based on the FOLFOX Regimen for Gastric Cancer? A Network Meta-analysis of Randomized Controlled Trials".ASIAN PACIFIC JOURNAL OF CANCER PREVENTION 15.12(2014):4795-4800.
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