兰州大学机构库 >基础医学院
Prognostic Significance of Beta-Catenin Expression in Patients with Esophageal Carcinoma: a Meta-analysis
Zeng, R; Duan, L; Kong, YK; Wu, XL; Wang, Y; Xin, G; Yang, KH(杨克虎); Yang, KH (reprint author), Lanzhou Univ, Evidence Based Med Ctr, Lanzhou 730000, Peoples R China.
Indexed BySCIE ; PubMed ; MEDLINE
2014-08-18
Source PublicationASIAN PACIFIC JOURNAL OF CANCER PREVENTION
ISSN1513-7368
Volume15Issue:15Pages:6103-6108
AbstractMany studies have reported beta-catenin involvement in the development of esophageal carcinoma (EC), but its prognostic significance for EC patients remains controversial. Therefore, we conducted this meta-analysis to explore the issue in detail. After searching PubMed, EMBASE, Web of Science, and Chinese Biomedical Literature Database, we included a total of ten relevant studies. We pooled the overall survival (OS) data using RevMan 5.2 software. The results showed that aberrant expression of beta-catenin was associated with a significant increase of mortality risk (hazard ratio 1.71, 95% CI 1.46-2.01; p<0.00001). Subgroup analyses further suggested that aberrant expression of beta-catenin resulted in poor OS of EC patients regardless of histological type of EC, study location or criteria for aberrant expression of beta-catenin, and the sensitivity analyses revealed that the result was robust. The meta-analysis revealed that aberrant expression of beta-catenin could be a predicative factor of poor prognosis for EC patients.
Keywordbeta-catenin esophageal carcinoma prognosis meta-analysis
Subject AreaOncology
PublisherASIAN PACIFIC ORGANIZATION CANCER PREVENTION
Publication PlaceGYEONGGI-DO
DOI10.7314/APJCP.2014.15.15.6103
First Inst
Language英语
SubtypeArticle
WOS IDWOS:000343723600024
PMID 25124581
Department[Zeng, Rong;
Duan, Lei;
Yang, Ke-Hu] Lanzhou Univ, Evidence Based Med Ctr, Lanzhou 730000, Peoples R China;
[Zeng, Rong;
Duan, Lei;
Kong, Yu-Ke;
Wu, Xiao-Lu;
Wang, Ya;
Xin, Gang] Lanzhou Univ, Hosp 2, Lanzhou 730000, Peoples R China
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.lzu.edu.cn/handle/262010/121734
Collection基础医学院
Corresponding AuthorYang, KH (reprint author), Lanzhou Univ, Evidence Based Med Ctr, Lanzhou 730000, Peoples R China.
Recommended Citation
GB/T 7714
Zeng, R,Duan, L,Kong, YK,et al. Prognostic Significance of Beta-Catenin Expression in Patients with Esophageal Carcinoma: a Meta-analysis[J]. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,2014,15(15):6103-6108.
APA Zeng, R.,Duan, L.,Kong, YK.,Wu, XL.,Wang, Y.,...&Yang, KH .(2014).Prognostic Significance of Beta-Catenin Expression in Patients with Esophageal Carcinoma: a Meta-analysis.ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,15(15),6103-6108.
MLA Zeng, R,et al."Prognostic Significance of Beta-Catenin Expression in Patients with Esophageal Carcinoma: a Meta-analysis".ASIAN PACIFIC JOURNAL OF CANCER PREVENTION 15.15(2014):6103-6108.
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