公共卫生学院机构知识库

Institutional Repository, School of Public health

 

兰州大学机构库  > 公共卫生学院  > 期刊论文
题名: Prediction of Inhibitory Activity of Epidermal Growth Factor Receptor Inhibitors Using Grid Search-Projection Pursuit Regression Method
作者: Du, HY; Hu, ZD(胡之德); Bazzoli, A; Zhang, Y
收录类别: SCIE
出版日期: 2011-07-21
刊名: PLOS ONE
卷号: 6, 期号:7, 页码:-
出版者: PLOS
出版地: SAN FRANCISCO
英文摘要: The epidermal growth factor receptor (EGFR) protein tyrosine kinase (PTK) is an important protein target for anti-tumor drug discovery. To identify potential EGFR inhibitors, we conducted a quantitative structure-activity relationship (QSAR) study on the inhibitory activity of a series of quinazoline derivatives against EGFR tyrosine kinase. Two 2D-QSAR models were developed based on the best multi-linear regression (BMLR) and grid-search assisted projection pursuit regression (GS-PPR) methods. The results demonstrate that the inhibitory activity of quinazoline derivatives is strongly correlated with their polarizability, activation energy, mass distribution, connectivity, and branching information. Although the present investigation focused on EGFR, the approach provides a general avenue in the structure-based drug development of different protein receptor inhibitors.
作者部门: [Du, Hongying ; Bazzoli, Andrea ; Zhang, Yang] Univ Michigan, Ctr Computat Med & Bioinformat, Ann Arbor, MI 48109 USA ; [Du, Hongying] Lanzhou Univ, Dept Publ Hlth, Lanzhou 730000, Peoples R China ; [Hu, Zhide] Lanzhou Univ, Dept Chem, Lanzhou 730000, Peoples R China
通讯作者: Du, HY (reprint author), Univ Michigan, Ctr Computat Med & Bioinformat, Ann Arbor, MI 48109 USA.
学科分类: Science & Technology - Other Topics
文章类型: Article
所属项目编号: Alfred P. Sloan Foundation ; NSF [DBI 1027394] ; National Institute of General Medical Sciences [GM083107, GM084222]
所属项目名称: 美国国家科学基金会项目
项目资助者: US NSF
语种: 英语
DOI: 10.1371/journal.pone.0022367
ISSN号: 1932-6203
WOS记录号: WOS:000292956800049
第一机构:
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/121799
Appears in Collections:公共卫生学院_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
Prediction of Inhibitory Activity of Epidermal.pdf(1036KB)----限制开放 联系获取全文

Recommended Citation:
Du, HY,Hu, ZD,Bazzoli, A,et al. Prediction of Inhibitory Activity of Epidermal Growth Factor Receptor Inhibitors Using Grid Search-Projection Pursuit Regression Method[J]. PLOS ONE,2011,6(7):-.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Altmetrics Score
 
Google Scholar
Similar articles in Google Scholar
[Du, HY]'s Articles
[Hu, ZD]'s Articles
[Bazzoli, A]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Du, HY]‘s Articles
[Hu, ZD]‘s Articles
[Bazzoli, A]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Email:
Passwd
验 证:
换一张
Have you forgotten your password? Log In
Copyright © 2007-2017  兰州大学 - Feedback
Powered by CSpace