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题名: The Role of Metal Components in the Cardiovascular Effects of PM2.5
作者: Niu, JP(牛静萍); Liberda, EN; Qu, S; Guo, XB; Li, XM; Zhang, JJ; Meng, JL; Yan, B; Li, NR; Zhong, MH; Ito, K; Wildman, R; Liu, H; Chen, LC; Qu, QS
收录类别: SCIE ; PubMed ; MEDLINE
出版日期: 2013-12-27
刊名: PLOS ONE
卷号: 8, 期号:12, 页码:-
出版者: PLOS
出版地: SAN FRANCISCO
英文摘要: Exposure to ambient fine particulate matter (PM2.5) increases risks for cardiovascular disorders (CVD). However, the mechanisms and components responsible for the effects are poorly understood. Based on our previous murine exposure studies, a translational pilot study was conducted in female residents of Jinchang and Zhangye, China, to test the hypothesis that specific chemical component of PM2.5 is responsible for PM2.5 associated CVD. Daily ambient and personal exposures to PM2.5 and 35 elements were measured in the two cities. A total of 60 healthy nonsmoking adult women residents were recruited for measurements of inflammation biomarkers. In addition, circulating endothelial progenitor cells (CEPCs) were also measured in 20 subjects. The ambient levels of PM2.5 were comparable between Jinchang and Zhangye (47.4 and 54.5 mu g/m(3), respectively). However, the levels of nickel, copper, arsenic, and selenium in Jinchang were 82, 26, 12, and 6 fold higher than Zhangye, respectively. The levels of C-reactive protein (3.44 +/- 3.46 vs. 1.55 +/- 1.13), interleukin-6 (1.65 +/- 1.17 vs. 1.09 +/- 0.60), and vascular endothelial growth factor (117.6 +/- 217.0 vs. 22.7 +/- 21.3) were significantly higher in Jinchang. Furthermore, all phenotypes of CEPCs were significantly lower in subjects recruited from Jinchang than those from Zhangye. These results suggest that specific metals may be important components responsible for PM2.5-induced cardiovascular effects and that the reduced capacity of endothelial repair may play a critical role.
作者部门: [Niu, Jingping ; Zhang, Jingjing ; Meng, Junliang ; Yan, Bing ; Li, Nairong] Lanzhou Univ, Sch Publ Hlth, Lanzhou 730000, Peoples R China ; [Liberda, Eric N. ; Li, Xiaomei ; Zhong, Mianhua ; Ito, Kazuhiko ; Chen, Lung Chi ; Qu, Qingshan] NYU, Sch Med, Nelson Inst Environm Med, Tuxedo Pk, NY USA ; [Qu, Song] NYU, Coll Arts & Sci, New York, NY USA ; [Guo, Xinbiao ; Liu, Hong] Peking Univ, Sch Publ Hlth, Beijing 100871, Peoples R China ; [Wildman, Rachel] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA
通讯作者: Chen, LC (reprint author), NYU, Sch Med, Nelson Inst Environm Med, Tuxedo Pk, NY USA.
学科分类: Science & Technology - Other Topics
文章类型: Article
所属项目编号: NIEHS [R21ES016570, R01ES015495, P30 ES00260]
所属项目名称: 加拿大卫生研究院项目
项目资助者: CIHR
语种: 英语
DOI: 10.1371/journal.pone.0083782
ISSN号: 1932-6203
WOS记录号: WOS:000329117900058
PM记录号: 24386277
第一机构:
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/121814
Appears in Collections:公共卫生学院_期刊论文

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Recommended Citation:
Niu, JP,Liberda, EN,Qu, S,et al. The Role of Metal Components in the Cardiovascular Effects of PM2.5[J]. PLOS ONE,2013,8(12):-.
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