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题名: The antagonism of aluminum against fluoride-induced oxidative stress and c-Fos overexpression in rat testes
作者: Wang, JL; Zhang, HJ; Xu, FX; Xu, FH; Zhang, K; Zhang, YM(张迎梅)
收录类别: SCIE ; PubMed ; MEDLINE ; BIOSIS
出版日期: 2014-02
刊名: TOXICOLOGY MECHANISMS AND METHODS
卷号: 24, 期号:2, 页码:136-141
出版者: INFORMA HEALTHCARE
出版地: LONDON
英文摘要: Sodium fluoride (NaF) has been found to interfere with the reproductive system of animals. However, the cellular mechanisms underlying the reproductive toxicity of fluoride are unclear. The present study aims to define a possible mechanism of NaF-induced reproductive toxicity with respect to mineral, oxidative stress and c-Fos expression and the role of aluminum (Al) in intervening the toxic effect of NaF on rat testes. Fifty-six male Wistar rats were treated with normal saline, 1.0, 2.0, and 3.0mg NaF/kg body weight (bw)/day, and each NaF concentration plus Al ion (0.1mg Al3+/kg bw/day). After 90 days, no significant changes in the contents of Fe and Cu were observed in any of the NaF-treated groups compared with those of the control group. There were, however, significant decreases in the contents of Ca in the 1.0mg NaF group, Zn in all NaF-treated groups and Mg in the 3.0mg NaF group. The levels of malondialdehyde (MDA) in the 1.0mg NaF group and hydrogen peroxide (H2O2) in the 2.0mg NaF group significantly increased, whereas the activity of nitric oxide synthase (NOS) significantly decreased in the 1.0mg NaF group. Meanwhile, the protein expression of c-Fos increased significantly in the 1.0 and 2.0mg NaF groups compared with the control group. Conversely, these changes were partially attenuated in rats simultaneously administered Al. The present study suggested that NaF could decrease the contents of Ca, Fe and Mg and enhance oxidative stress leading to c-Fos overexpression, and some deleterious effects were more prominent at lower NaF intake. Furthermore, Al within the research concentration could minimize reproductive toxicity caused by fluoride.
关键词: Aluminum ; c-Fos ; fluoride ; male rat reproduction ; mineral ; oxidative stress
作者部门: [Wang, Junling ; Zhang, Haojun ; Xu, Feihua ; Zhang, Ke] Lanzhou Univ, Sch Publ Hlth, Lanzhou 730000, Peoples R China ; [Zhang, Haojun] Peoples Hosp Gansu Prov, Lanzhou, Peoples R China ; [Xu, Feixue] Lanzhou Univ, Affiliated Hosp 1, Lanzhou 730000, Peoples R China ; [Zhang, Yingmei] Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Peoples R China
通讯作者: Zhang, YM (reprint author), Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Peoples R China.
学科分类: Toxicology
文章类型: Article
所属项目编号: Fundamental Research Funds for the Central Universities [lzujbky-2012-156]
所属项目名称: 中央高校基本科研业务费专项资金
项目资助者: LZU
语种: 英语
DOI: 10.3109/15376516.2013.869779
ISSN号: 1537-6516
WOS记录号: WOS:000331064700005
PM记录号: 24304007
BIOSIS记录号: BIOSIS:PREV201400261179
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/121815
Appears in Collections:公共卫生学院_期刊论文

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Recommended Citation:
Wang, JL,Zhang, HJ,Xu, FX,et al. The antagonism of aluminum against fluoride-induced oxidative stress and c-Fos overexpression in rat testes[J]. TOXICOLOGY MECHANISMS AND METHODS,2014,24(2):136-141.
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