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题名: Prenatal exposure to organochlorine pesticides and infant birth weight in China
作者: Guo, H; Jin, YL; Cheng, YB; Leaderer, B; Lin, SB; Holford, TR; Qiu, J; Zhang, YW; Shi, KC; Zhu, Y; Niu, JJ; Bassig, BA; Xu, SQ; Zhang, B; Li, YH; Hu, XB; Chen, Q; Zheng, TZ
收录类别: SCIE ; EI
出版日期: 2014-09
刊名: Chemosphere
卷号: 110, 页码:1-7
出版者: ELSEVIER
出版地: OXFORD
英文摘要: In utero exposure to organochlorine pesticides (OCPs) is thought to be potentially harmful to fetal development. We aimed to investigate the associations of maternal and cord serum OCPs levels with infant birth weight in China. In this study, we measured serum levels of 18 OCPs in 81 mother-infant pairs, including DDT, hexachlorocyclohexanes (BHC), hexachlorobenzene (HCB), heptachlors, chlordanes, endosulfan-I, and mirex using a high-resolution-gas-chromatography with high-resolution-mass-spectrometry method. We found that p,p'-DDE and beta-BHC had the highest detection rate in both maternal and cord blood serum (97.2% and 96.7%, respectively), followed by HCB (93.0%, 51.7%), p,p'-DDT (88.7%, 36.7%), and p,p'-DDD (83.1%, 60.0%). Among all OCPs, the concentration of p,p'-DDE was the highest (mothers geometric mean (GM): 203.54 ng g(-1), newborns GM: 116.14 ng g(-1)), followed by HCB (70.62 ng g(-1), 65.16 ng g(-1)), and beta-BHC (67.67 ng g(-1), 33.39 ng g(-1)). Multiple linear regression analyses showed that each 1 ng g(-1) increment of cord serum p,p'-DDE, total DDT, and beta-BHC was associated with a 0.10 g, 0.10 g, and 0.92 g decrease in infant birth weight, respectively, and as the cord serum concentrations of p,p'-DDT, p,p'-DDD, HCB and mirex increased, the infant birth weight was also decreased, although the associations were not statistically significant due to the relatively small sample size. These results suggest that p,p'-DDE, beta-BHC, and HCB were the predominant OCPs in the serum of Chinese pregnant women and cord blood of their newborns. Prenatal exposure to DDT, beta-BHC, HCB, and mirex were associated with a decrease in birth weight, but these results need validation in larger sample-sized studies. (C) 2014 Elsevier Ltd. All rights reserved.
关键词: Prenatal exposure ; Organochlorine pesticides ; Dichloro-diphenyl-trichloroethane ; beta-Hexachlorocyclohexane ; Hexachlorobenzene ; Birth weight
作者部门: [Guo, Huan ; Leaderer, Brian ; Holford, Theodore R. ; Zhang, Yawei ; Zhu, Yong ; Bassig, Bryan A. ; Hu, Xiaobin ; Chen, Qiong ; Zheng, Tongzhang] Yale Univ, Sch Publ Hlth, New Haven, CT 06510 USA ; [Guo, Huan ; Xu, Shunqing] Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China ; [Jin, Yinlong ; Cheng, Yibin ; Lin, Shaobin ; Li, Yonghong] China CDC, Inst Environm Hlth & Related Prod Safety, Beijing 100021, Peoples R China ; [Qiu, Jie] Gansu Prov Matern & Child Care Hosp, Lanzhou 730050, Gansu, Peoples R China ; [Shi, Kunchong] Beijing Fentail Women & Childrens Hosp, Beijing 100067, Peoples R China ; [Niu, Jianjun] Xiamen City Ctr Dis Control & Prevent, Xiamen 361021, Peoples R China ; [Zhang, Bin] Wuhan City Childrens Hosp, Wuhan, Peoples R China ; [Hu, Xiaobin] Lanzhou Univ, Sch Publ Hlth, Lanzhou 730000, Gansu, Peoples R China ; [Chen, Qiong] Canc Hosp Henan Prov, Off Canc Res & Control, Zhengzhou 450008, Peoples R China
通讯作者: Zheng, TZ (reprint author), Yale Univ, Sch Publ Hlth, Dept Environm Hlth Sci, New Haven, CT 06510 USA.
学科分类: Environmental Sciences & Ecology
文章类型: Article
所属项目编号: Fogarty training from Fogarty International Center, National Institutes of Health, USA [D43TW 008323, D43TW 007864-01]
所属项目名称: 美国国立卫生研究院项目
项目资助者: NIH
语种: 英语
DOI: 10.1016/j.chemosphere.2014.02.017
ISSN号: 0045-6535
WOS记录号: WOS:000337770400001
EI记录号: 20160501870585
IR记录号: 20160501870585
第一机构:
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/121819
Appears in Collections:公共卫生学院_期刊论文

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Recommended Citation:
Guo, H,Jin, YL,Cheng, YB,et al. Prenatal exposure to organochlorine pesticides and infant birth weight in China[J]. Chemosphere,2014,110:1-7.
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