公共卫生学院机构知识库

Institutional Repository, School of Public health

 

兰州大学机构库  > 公共卫生学院  > 期刊论文
题名: Synthesis and Biological Evaluation of New Pleuromutilin Derivatives as Antibacterial Agents
作者: Shang, RF; Wang, GH; Xu, XM; Liu, SJ; Zhang, C; Yi, YP; Liang, JP; Liu, Y
收录类别: SCIE
出版日期: 2014-11
刊名: MOLECULES
卷号: 19, 期号:11, 页码:19050-19065
出版者: MDPI AG
出版地: BASEL
英文摘要: Several pleuromutilin derivatives possessing thiadiazole moieties were synthesized via acylation reactions under mild conditions. The in vitro antibacterial activities of the derivatives against methicillin-resistant S. aureus, methicillin-resistant S. epidermidis, S. aureus, S. epidermidis, E. coli, and B. cereus were tested by the agar dilution method and Oxford cup assay. All the screened compounds displayed potent activity. Compound 6d was the most active antibacterial agent because of its lowest MIC value and largest inhibition zone. Docking experiments were performed to understand the possible mode of the interactions between the derivatives and 50S ribosomal subunit. Moreover, the absorption, distribution, metabolism, excretion and toxicity properties of the synthesized compounds were analyzed after prediction using the Advanced Chemistry Development/Percepta Platform available online.
关键词: pleuromutilin derivatives ; antibacterial activity ; synthesis ; molecular docking ; ADMET properties
作者部门: [Shang, Ruo-Feng ; Zhang, Chao ; Yi, Yun-Peng ; Liang, Jian-Ping ; Liu, Yu] Minist Agr, Lanzhou Inst Husb & Pharmaceut Sci CAAS, Key Lab Vet Pharmaceut Dev, Key Lab New Anim Drug Project Gansu Prov, Lanzhou 730050, Peoples R China ; [Wang, Guan-Hua] Lanzhou Univ, Sch Publ Hlth, Lanzhou 730000, Peoples R China ; [Xu, Xi-Ming] Guiyang Med Univ, Sch Publ Hlth, Dept Toxicol, Guiyang 550004, Peoples R China ; [Liu, Si-Jie] Shijiazhuang Univ, Coll Chem Engn, Shijiazhuang 050035, Peoples R China
通讯作者: Liang, JP (reprint author), Minist Agr, Lanzhou Inst Husb & Pharmaceut Sci CAAS, Key Lab Vet Pharmaceut Dev, Key Lab New Anim Drug Project Gansu Prov, Lanzhou 730050, Peoples R China.
学科分类: Chemistry
文章类型: Article
所属项目编号: Basic Scientific Research Funds in Central Agricultural Scientific Research Institutions [1610322014003] ; Agricultural Science and Technology Innovation Program (ASTIP) ; "Five-Year" plan of national science and technology projects in rural areas [2011AA10A214]
所属项目名称: 国家高技术研究发展计划(863计划)
项目资助者: MOST
语种: 英语
DOI: 10.3390/molecules191119050
ISSN号: 1420-3049
WOS记录号: WOS:000345564300117
第一机构:
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/121823
Appears in Collections:公共卫生学院_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
Synthesis and Biological Evaluation of New Ple.pdf(2267KB)----限制开放 联系获取全文

Recommended Citation:
Shang, RF,Wang, GH,Xu, XM,et al. Synthesis and Biological Evaluation of New Pleuromutilin Derivatives as Antibacterial Agents[J]. MOLECULES,2014,19(11):19050-19065.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Altmetrics Score
 
Google Scholar
Similar articles in Google Scholar
[Shang, RF]'s Articles
[Wang, GH]'s Articles
[Xu, XM]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Shang, RF]‘s Articles
[Wang, GH]‘s Articles
[Xu, XM]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Email:
Passwd
验 证:
换一张
Have you forgotten your password? Log In
Copyright © 2007-2017  兰州大学 - Feedback
Powered by CSpace