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题名: Rat Lung Response to PM2.5 Exposure under Different Cold Stresses
作者: Luo, B(罗斌); Shi, HX; Wang, LN; Shi, YR; Wang, C; Yang, JL; Wan, YX; Niu, JP(牛静萍)
收录类别: SCIE ; PubMed ; MEDLINE
出版日期: 2014-12
刊名: International journal of environmental research and public health
卷号: 11, 期号:12, 页码:12915-12926
出版者: MDPI AG
出版地: BASEL
英文摘要: Ambient particulate matters and temperature were reported to have additive effects over the respiratory disease hospital admissions and deaths. The purpose of this study is to discuss the interactive pulmonary toxicities of cold stress and fine particulate matter (PM2.5) exposure by estimating inflammation and oxidative stress responses. 48 Wistar male rats, matched by weight and age, were randomly assigned to six groups, which were treated with cold stress alone (0 degrees C, 10 degrees C, and 20 degrees C (Normal control)) and cold stresses plus PM2.5 exposures respectively. Cold stress alone groups were intratracheal instillation of 0.25 mL normal saline, while cold stress plus PM2.5 exposure groups were intratracheal instillation of 8 mg/0.25 mL PM2.5. These procedures were carried out for three times with an interval of 48 hours for each treatment. All rats were sacrificed after 48 hours of the third treatment. The bronchoalveolar lavage fluid (BALF) was collected for analyzing inflammatory cells and cytokines, and lung homogenate MDA was determined for oxidative stress estimation. Results showed higher level of total cell and neutrophil in the BALF of PM2.5 exposed groups (p < 0.05). Negative relationships between cold stress intensity and the level of tumor necrosis factor alpha (TNF-a), C-reactive protein (CRP) interleukin-6 (IL-6) and interleukin-8 (IL-8) in BALF were indicated in PM2.5 exposure groups. Exposure to cold stress alone caused significant increase of inflammatory cytokines and methane dicarboxylic aldehyde (MDA) and decline of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity only in 0 degrees C exposure group (p < 0.05). The two-way ANOVA found significant interactive effects between PM2.5 exposure and cold stress in the level of neutrophil, IL-6 and IL-8 and SOD activity (p < 0.05). These data demonstrated that inflammation and oxidative stress involved in the additive effect of PM2.5 exposure and cold stress on pulmonary toxicity, providing explanation for epidemiological studies on the health effect of ambient PM2.5 and cold stress.
关键词: fine particulate matter (PM2.5) ; cold stress ; inflammatory response ; oxidative stress ; rat lung
作者部门: [Luo, Bin ; Wang, Lina ; Shi, Yanrong ; Wang, Cheng ; Yang, Jingli ; Wan, Yaxiong ; Niu, Jingping] Lanzhou Univ, Inst Occupat Hlth & Environm Hlth, Sch Publ Hlth, Lanzhou 730000, Peoples R China ; [Shi, Hongxia] Lanzhou Univ, Hosp 2, Lanzhou 730030, Peoples R China
通讯作者: Luo, B (reprint author), Lanzhou Univ, Inst Occupat Hlth & Environm Hlth, Sch Publ Hlth, Lanzhou 730000, Peoples R China.
学科分类: Environmental Sciences & Ecology
文章类型: Article
所属项目编号: National Natural Science Foundation of China [41405108] ; Elementary research foundation for Central University of Lanzhou University [861495]
所属项目名称: 国家自然科学基金项目 ; 中央高校基本科研业务费专项资金
项目资助者: NSFC ; LZU
语种: 英语
DOI: 10.3390/ijerph111212915
ISSN号: 1660-4601
WOS记录号: WOS:000346797100052
PM记录号: 25514147
IR记录号: 25587610
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/121825
Appears in Collections:公共卫生学院_期刊论文

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Recommended Citation:
Luo, B,Shi, HX,Wang, LN,et al. Rat Lung Response to PM2.5 Exposure under Different Cold Stresses[J]. International journal of environmental research and public health,2014,11(12):12915-12926.
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