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题名: Slit-Robo: A potential way to treat periodontitis
作者: Zhao, Y(赵媛); Su, YY; Ye, L
收录类别: SCIE
出版日期: 2012-08
刊名: MEDICAL HYPOTHESES
卷号: 79, 期号:2, 页码:186-188
出版者: CHURCHILL LIVINGSTONE
出版地: EDINBURGH
英文摘要: Slit is a secreted protein known to function through the Roundabout (Robo) receptor. Slit has recently been shown to be an endogenously available inhibitor of leukocyte chemotaxis and as a chemoattractant to recruit vascular endothelial cells to sites for angiogenesis both in vivo and in vitro. The initiation and progression of periodontal diseases, is the result of complex interactions between the colonizing bacteria in the periodontal pockets and host immune and inflammatory responses. Antibiotics such as tetracyclines are commonly used in the management of periodontal infections and yet, have shown modest success in reducing neutrophil-mediated injury. Angiogenesis is important for the maintenance of homeostatus of periodontal tissues. However, few studies have been reported about angiogenesis targeted treatment for periodontitis. Based on its angiogenesis promoting effect and leukocyte chemotaxis inhibition effect, we hypothesize that Slit can be an effective immunotherapeutic agent in the treatment of periodontitis. (C) 2012 Elsevier Ltd. All rights reserved.
作者部门: [Ye, Ling] Sichuan Univ, W China Coll Stomatol, State Key Lab Oral Dis, W China Sch Stomatol,Sect Ren Ming Nan Lu 3, Chengdu 610041, Peoples R China ; [Zhao, Yuan] Lanzhou Univ, Coll Stomatol, Dept Oral Basic Sci, Lanzhou 730000, Peoples R China
通讯作者: Ye, L (reprint author), Sichuan Univ, W China Coll Stomatol, State Key Lab Oral Dis, W China Sch Stomatol,Sect Ren Ming Nan Lu 3, Chengdu 610041, Peoples R China.
学科分类: Research & Experimental Medicine
文章类型: Article
所属项目编号: Youth Foundation of Gansu Province, China [1007RJYA009] ; National Natural Science Foundation of China [81070801] ; New Century Excellent Talents Fund [NCET-10-0577] ; Sichuan University
所属项目名称: 国家自然科学基金项目 ; 新世纪优秀人才支持计划 ; 甘肃省青年科技基金计划
项目资助者: NSFC ; MOE ; GSSTD
语种: 英语
DOI: 10.1016/j.mehy.2012.04.030
ISSN号: 0306-9877
WOS记录号: WOS:000306770700017
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/122095
Appears in Collections:口腔医学院_期刊论文

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Recommended Citation:
Zhao, Y,Su, YY,Ye, L. Slit-Robo: A potential way to treat periodontitis[J]. MEDICAL HYPOTHESES,2012,79(2):186-188.
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