兰州大学机构库 >口腔医学院
A Novel Wound Dressing Based on Ag/Graphene Polymer Hydrogel: Effectively Kill Bacteria and Accelerate Wound Healing
Fan, ZJ(范增杰); Liu, B(刘斌); Wang, JQ; Zhang, SY; Lin, QQ; Gong, PW; Ma, LM; Yang, SR; Fan, ZJ (reprint author), Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, 18 Tianshui Middle Rd, Lanzhou 730000, Peoples R China.
收录类别SCIE ; EI
2014-07-02
发表期刊ADVANCED FUNCTIONAL MATERIALS
卷号24期号:25页码:3933-3943
出版者WILEY
出版地WEINHEIM
摘要Avoiding wound infection and retaining an appropriate level of moisture around woundz are major challenges in wound care management. Therefore, designing hydrogels with desired antibacterial performance and good water-maintaining ability is of particular significance to promote the development of wound dressing. Thus a series of hydrogels are prepared by crosslinking of Ag/graphene composites with acrylic acid and N,N'-methylene bisacrylamide at different mass ratios. The antibacterial performance and accelerated wound-healing ability of hydrogel are systematically evaluated with the aim of attaining a novel and effective wound dressing. The as-prepared hydrogel with the optimal Ag to graphene mass ratio of 5:1 (Ag5G1) exhibits stronger antibacterial abilities than other hydrogels. Meanwhile, Ag5G1 hydrogel exhibits excellent biocompatibility, high swelling ratio, and good extensibility. More importantly, in vivo experiments indicate that Ag5G1 hydrogel can significantly accelerate the healing rate of artificial wounds in rats, and histological examination reveals that it helps to successfully reconstruct intact and thickened epidermis during 15 day of healing of impaired wounds. In one word, the present approach can shed new light on designing of antibacterial material like Ag/graphene composite hydrogel with promising applications in wound dressing.
作者部门[Fan, Zengjie;
Wang, Jinqing;
Gong, Peiwei;
Ma, Limin;
Yang, Shengrong] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, Lanzhou 730000, Peoples R China;
[Liu, Bin;
Zhang, Songying;
Lin, Qianqian] Lanzhou Univ, Sch Stomatol, Lanzhou 730000, Peoples R China
学科领域Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
所属项目编号National Natural Science Foundation of China [51205385, 51075384] ; "Top Hundred Talents Program" of Chinese Academy of Sciences
资助项目国家自然科学基金项目
项目资助者NSFC
DOI10.1002/adfm.201304202
ISSN1616-301X
文章类型Article
语种英语
WOS记录号WOS:000338011200010
EI记录号20142717902847
第一机构
Citation statistics
文献类型期刊论文
条目标识符http://ir.lzu.edu.cn/handle/262010/122117
Collection口腔医学院
通讯作者Fan, ZJ (reprint author), Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, 18 Tianshui Middle Rd, Lanzhou 730000, Peoples R China.
Recommended Citation:
GB/T 7714
Fan, ZJ,Liu, B,Wang, JQ,et al. A Novel Wound Dressing Based on Ag/Graphene Polymer Hydrogel: Effectively Kill Bacteria and Accelerate Wound Healing[J]. ADVANCED FUNCTIONAL MATERIALS,2014,24(25):3933-3943.
APA Fan, ZJ.,Liu, B.,Wang, JQ.,Zhang, SY.,Lin, QQ.,...&Fan, ZJ .(2014).A Novel Wound Dressing Based on Ag/Graphene Polymer Hydrogel: Effectively Kill Bacteria and Accelerate Wound Healing.ADVANCED FUNCTIONAL MATERIALS,24(25),3933-3943.
MLA Fan, ZJ,et al."A Novel Wound Dressing Based on Ag/Graphene Polymer Hydrogel: Effectively Kill Bacteria and Accelerate Wound Healing".ADVANCED FUNCTIONAL MATERIALS 24.25(2014):3933-3943.
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