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题名: A Novel Wound Dressing Based on Ag/Graphene Polymer Hydrogel: Effectively Kill Bacteria and Accelerate Wound Healing
作者: Fan, ZJ; Liu, B(刘斌); Wang, JQ; Zhang, SY; Lin, QQ; Gong, PW; Ma, LM; Yang, SR
收录类别: SCIE ; EI
出版日期: 2014-07-02
刊名: ADVANCED FUNCTIONAL MATERIALS
卷号: 24, 期号:25, 页码:3933-3943
出版者: WILEY
出版地: WEINHEIM
英文摘要: Avoiding wound infection and retaining an appropriate level of moisture around woundz are major challenges in wound care management. Therefore, designing hydrogels with desired antibacterial performance and good water-maintaining ability is of particular significance to promote the development of wound dressing. Thus a series of hydrogels are prepared by crosslinking of Ag/graphene composites with acrylic acid and N,N'-methylene bisacrylamide at different mass ratios. The antibacterial performance and accelerated wound-healing ability of hydrogel are systematically evaluated with the aim of attaining a novel and effective wound dressing. The as-prepared hydrogel with the optimal Ag to graphene mass ratio of 5:1 (Ag5G1) exhibits stronger antibacterial abilities than other hydrogels. Meanwhile, Ag5G1 hydrogel exhibits excellent biocompatibility, high swelling ratio, and good extensibility. More importantly, in vivo experiments indicate that Ag5G1 hydrogel can significantly accelerate the healing rate of artificial wounds in rats, and histological examination reveals that it helps to successfully reconstruct intact and thickened epidermis during 15 day of healing of impaired wounds. In one word, the present approach can shed new light on designing of antibacterial material like Ag/graphene composite hydrogel with promising applications in wound dressing.
作者部门: [Fan, Zengjie ; Wang, Jinqing ; Gong, Peiwei ; Ma, Limin ; Yang, Shengrong] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, Lanzhou 730000, Peoples R China ; [Liu, Bin ; Zhang, Songying ; Lin, Qianqian] Lanzhou Univ, Sch Stomatol, Lanzhou 730000, Peoples R China
通讯作者: Fan, ZJ (reprint author), Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, 18 Tianshui Middle Rd, Lanzhou 730000, Peoples R China.
学科分类: Chemistry; Science & Technology - Other Topics; Materials Science; Physics
文章类型: Article
所属项目编号: National Natural Science Foundation of China [51205385, 51075384] ; "Top Hundred Talents Program" of Chinese Academy of Sciences
所属项目名称: 国家自然科学基金项目
项目资助者: NSFC
语种: 英语
DOI: 10.1002/adfm.201304202
ISSN号: 1616-301X
WOS记录号: WOS:000338011200010
EI记录号: 20142717902847
第一机构:
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/122117
Appears in Collections:口腔医学院_期刊论文

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Recommended Citation:
Fan, ZJ,Liu, B,Wang, JQ,et al. A Novel Wound Dressing Based on Ag/Graphene Polymer Hydrogel: Effectively Kill Bacteria and Accelerate Wound Healing[J]. ADVANCED FUNCTIONAL MATERIALS,2014,24(25):3933-3943.
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