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题名: Heavy ion and X-ray irradiation alter the cytoskeleton and cytomechanics of cortical neurons
作者: Du, YT; Zhang, J; Zheng, Q; Li, MX; Liu, Y; Zhang, BP; Liu, B(刘斌); Zhang, H; Miao, GY
收录类别: SCIE ; PubMed ; BIOSIS ; CSCD
出版日期: 2014-06
刊名: NEURAL REGENERATION RESEARCH
卷号: 9, 期号:11, 页码:1129-1137
出版者: SHENYANG EDITORIAL DEPT NEURAL REGENERATION RES
出版地: SHENYANG
英文摘要: Heavy ion beams with high linear energy transfer exhibit more beneficial physical and biological performance than conventional X-rays, thus improving the potential of this type of radiotherapy in the treatment of cancer. However, these two radiotherapy modalities both cause inevitable brain injury. The objective of this study was to evaluate the effects of heavy ion and X-ray irradiation on the cytoskeleton and cytomechanical properties of rat cortical neurons, as well as to determine the potential mechanism of neuronal injury after irradiation. Cortical neurons from 30 new-born mice were irradiated with heavy ion beams at a single dose of 2 Gy and X-rays at a single dose of 4 Gy; subsequent evaluation of their effects were carried out at 24 hours after irradiation. An immunofluorescence assay showed that after irradiation with both the heavy ion beam and X-rays, the number of primary neurons was significantly decreased, and there was evidence of apoptosis. Radiation-induced neuronal injury was more apparent after X-irradiation. Under atomic force microscopy, the neuronal membrane appeared rough and neuronal rigidity had increased. These cell changes were more apparent following exposure to X-rays. Our findings indicated that damage caused by heavy ion and X-ray irradiation resulted in the structural distortion and rearrangement of the cytoskeleton, and affected the cytomechanical properties of the cortical neurons. Moreover, this radiation injury to normal neurons was much severer after irradiation with X-rays than after heavy ion beam irradiation.
关键词: nerve regeneration ; radiation brain injury ; neurons ; heavy ion ; X-ray ; cytoskeleton ; cytomechanical properties ; atomic force microscopy ; neural regeneration
作者部门: [Du, Yuting ; Zhang, Jie ; Zheng, Qian ; Li, Mingxin ; Liu, Bin] Lanzhou Univ, Sch Stomatol, Lanzhou 730000, Gansu, Peoples R China ; [Du, Yuting ; Zhang, Jie ; Liu, Bin] Lanzhou Univ, Sch Nucl Sci & Technol, Lanzhou 730000, Gansu, Peoples R China ; [Liu, Yang ; Zhang, Hong] Chinese Acad Sci, Dept Radiat Biol & Med, Inst Modern Phys, Lanzhou, Gansu, Peoples R China ; [Zhang, Baoping] Lanzhou Univ, Sch Civil Engn & Mech, Lanzhou 730000, Gansu, Peoples R China ; [Miao, Guoying] Gansu Prov Hosp, Lanzhou, Gansu, Peoples R China
通讯作者: Liu, B (reprint author), Lanzhou Univ, Sch Nucl Sci & Technol, Lanzhou 730000, Gansu, Peoples R China.
学科分类: Cell Biology; Neurosciences & Neurology
文章类型: Article
语种: 英语
DOI: 10.4103/1673-5374.135315
ISSN号: 1673-5374
WOS记录号: WOS:000338803900010
CSCD记录号: CSCD:5185861
PM记录号: 25206772
BIOSIS记录号: BIOSIS:PREV201400586431
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/122120
Appears in Collections:口腔医学院_期刊论文

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Recommended Citation:
Du, YT,Zhang, J,Zheng, Q,et al. Heavy ion and X-ray irradiation alter the cytoskeleton and cytomechanics of cortical neurons[J]. NEURAL REGENERATION RESEARCH,2014,9(11):1129-1137.
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