兰州大学机构库 >口腔医学院
Heavy ion and X-ray irradiation alter the cytoskeleton and cytomechanics of cortical neurons
Du, YT; Zhang, J; Zheng, Q; Li, MX; Liu, Y; Zhang, BP; Liu, B(刘斌); Zhang, H; Miao, GY; Liu, B (reprint author), Lanzhou Univ, Sch Nucl Sci & Technol, Lanzhou 730000, Gansu, Peoples R China.
收录类别SCIE ; PubMed ; BIOSIS ; CSCD
2014-06
发表期刊NEURAL REGENERATION RESEARCH
卷号9期号:11页码:1129-1137
出版者SHENYANG EDITORIAL DEPT NEURAL REGENERATION RES
出版地SHENYANG
摘要Heavy ion beams with high linear energy transfer exhibit more beneficial physical and biological performance than conventional X-rays, thus improving the potential of this type of radiotherapy in the treatment of cancer. However, these two radiotherapy modalities both cause inevitable brain injury. The objective of this study was to evaluate the effects of heavy ion and X-ray irradiation on the cytoskeleton and cytomechanical properties of rat cortical neurons, as well as to determine the potential mechanism of neuronal injury after irradiation. Cortical neurons from 30 new-born mice were irradiated with heavy ion beams at a single dose of 2 Gy and X-rays at a single dose of 4 Gy; subsequent evaluation of their effects were carried out at 24 hours after irradiation. An immunofluorescence assay showed that after irradiation with both the heavy ion beam and X-rays, the number of primary neurons was significantly decreased, and there was evidence of apoptosis. Radiation-induced neuronal injury was more apparent after X-irradiation. Under atomic force microscopy, the neuronal membrane appeared rough and neuronal rigidity had increased. These cell changes were more apparent following exposure to X-rays. Our findings indicated that damage caused by heavy ion and X-ray irradiation resulted in the structural distortion and rearrangement of the cytoskeleton, and affected the cytomechanical properties of the cortical neurons. Moreover, this radiation injury to normal neurons was much severer after irradiation with X-rays than after heavy ion beam irradiation.
关键词nerve regeneration radiation brain injury neurons heavy ion X-ray cytoskeleton cytomechanical properties atomic force microscopy neural regeneration
作者部门
[Du, Yuting;
Zhang, Jie;
Zheng, Qian;
Li, Mingxin;
Liu, Bin] Lanzhou Univ, Sch Stomatol, Lanzhou 730000, Gansu, Peoples R China;
[Du, Yuting;
Zhang, Jie;
Liu, Bin] Lanzhou Univ, Sch Nucl Sci & Technol, Lanzhou 730000, Gansu, Peoples R China;
[Liu, Yang;
Zhang, Hong] Chinese Acad Sci, Dept Radiat Biol & Med, Inst Modern Phys, Lanzhou, Gansu, Peoples R China...更多
学科领域Cell Biology ; Neurosciences & Neurology
DOI10.4103/1673-5374.135315
ISSN1673-5374
文章类型Article
语种英语
WOS记录号WOS:000338803900010
CSCD记录号CSCD:5185861
PM记录号25206772
BIOSIS记录号BIOSIS:PREV201400586431
第一机构
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文献类型期刊论文
条目标识符http://ir.lzu.edu.cn/handle/262010/122120
Collection口腔医学院
通讯作者Liu, B (reprint author), Lanzhou Univ, Sch Nucl Sci & Technol, Lanzhou 730000, Gansu, Peoples R China.
Recommended Citation:
GB/T 7714
Du, YT,Zhang, J,Zheng, Q,et al. Heavy ion and X-ray irradiation alter the cytoskeleton and cytomechanics of cortical neurons[J]. NEURAL REGENERATION RESEARCH,2014,9(11):1129-1137.
APA Du, YT.,Zhang, J.,Zheng, Q.,Li, MX.,Liu, Y.,...&Liu, B .(2014).Heavy ion and X-ray irradiation alter the cytoskeleton and cytomechanics of cortical neurons.NEURAL REGENERATION RESEARCH,9(11),1129-1137.
MLA Du, YT,et al."Heavy ion and X-ray irradiation alter the cytoskeleton and cytomechanics of cortical neurons".NEURAL REGENERATION RESEARCH 9.11(2014):1129-1137.
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