兰州大学机构库 >口腔医学院
The effects of x-ray radiation on the eye development of zebrafish
Zhou, R; Si, J; Zhang, H; Wang, Z; Li, J; Zhou, X; Can, L; Liu, Y; Zhang, H (reprint author), Chinese Acad Sci, Inst Modern Phys, Dept Heavy Ion Radiat Med, Lanzhou 730000, Peoples R China.
Indexed BySCIE
2014-10
Source PublicationHUMAN & EXPERIMENTAL TOXICOLOGY
Volume33Issue:10Pages:1040-1050
PublisherSAGE
Publication PlaceLONDON
AbstractThe toxic effects of x-ray radiation on eye development was measured using zebrafish as a model organism. Zebrafish embryos at 8 h post-fertilization (hpf) were irradiated using X-rays at doses of 1, 2, 4, and 8 Gy. At 24 and 48 hpf, x-ray radiation induced a significant increase in reactive oxygen species (ROS) content and cell apoptotic signals. Both of these increases were dose dependent and there were significant positive relationships between them at 24 hpf. At 48 and 72 hpf, the increase of ROS concentration can be eliminated by increasing activities of superoxide dismutase and catalase. Although the ROS generated by x-ray radiation caused a significant increase in cell apoptosis at 24 and 48 hpf, the cellular layers of the retina and lens formation in the irradiated groups were not significantly disrupted at 144 hpf compared with the control group, with the exception of a heterogeneous distribution of the cells in inner nuclear cell layer and a significant decrease in the diameters of whole eyes after 8 Gy irradiation. X-Ray radiation at later stages of gastrulation may not cause distinct optic complications; however, there is still a risk of microophthalmia at high doses of irradiation.
KeywordX-Ray eye development zebrafish cell apoptosis reactive oxygen species microophthalmia
Department
[Zhou, R.;
Si, J.;
Zhang, H.;
Zhou, X.;
Can, L.;
Liu, Y.] Chinese Acad Sci, Inst Modern Phys, Dept Med Phys, Lanzhou 730000, Peoples R China;
[Zhou, R.;
Si, J.;
Zhang, H.;
Zhou, X....更多
Subject AreaToxicology
Project NumberNational Basic Research Program of China [2010CB834202] ; National Natural Science Foundation of China [10835011] ; Scientific Technology Research Projects of Gansu Province [0702NKDA045, 0806RJYA020]
Funding Project国家自然科学基金项目 ; 国家重点基础研究发展计划以及国家重大科学研究计划(973计划) ; 甘肃省青年科技基金计划 ; 甘肃省科技重大专项计划
Funding OrganizationNSFC ; MOST ; GSSTD
DOI10.1177/0960327114522278
ISSN0960-3271
SubtypeArticle
Language英语
WOS IDWOS:000343382400005
First Inst
Citation statistics
Document Type期刊论文
Identifierhttp://ir.lzu.edu.cn/handle/262010/122123
Collection口腔医学院
Corresponding AuthorZhang, H (reprint author), Chinese Acad Sci, Inst Modern Phys, Dept Heavy Ion Radiat Med, Lanzhou 730000, Peoples R China.
Recommended Citation
GB/T 7714
Zhou, R,Si, J,Zhang, H,et al. The effects of x-ray radiation on the eye development of zebrafish[J]. HUMAN & EXPERIMENTAL TOXICOLOGY,2014,33(10):1040-1050.
APA Zhou, R.,Si, J.,Zhang, H.,Wang, Z.,Li, J.,...&Zhang, H .(2014).The effects of x-ray radiation on the eye development of zebrafish.HUMAN & EXPERIMENTAL TOXICOLOGY,33(10),1040-1050.
MLA Zhou, R,et al."The effects of x-ray radiation on the eye development of zebrafish".HUMAN & EXPERIMENTAL TOXICOLOGY 33.10(2014):1040-1050.
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