兰州大学机构库 >口腔医学院
The effects of x-ray radiation on the eye development of zebrafish
Zhou, R; Si, J; Zhang, H; Wang, Z; Li, J; Zhou, X; Can, L; Liu, Y; Zhang, H (reprint author), Chinese Acad Sci, Inst Modern Phys, Dept Heavy Ion Radiat Med, Lanzhou 730000, Peoples R China.
2014-10
发表期刊HUMAN & EXPERIMENTAL TOXICOLOGY
ISSN0960-3271
卷号33期号:10页码:1040-1050
出版者SAGE
摘要The toxic effects of x-ray radiation on eye development was measured using zebrafish as a model organism. Zebrafish embryos at 8 h post-fertilization (hpf) were irradiated using X-rays at doses of 1, 2, 4, and 8 Gy. At 24 and 48 hpf, x-ray radiation induced a significant increase in reactive oxygen species (ROS) content and cell apoptotic signals. Both of these increases were dose dependent and there were significant positive relationships between them at 24 hpf. At 48 and 72 hpf, the increase of ROS concentration can be eliminated by increasing activities of superoxide dismutase and catalase. Although the ROS generated by x-ray radiation caused a significant increase in cell apoptosis at 24 and 48 hpf, the cellular layers of the retina and lens formation in the irradiated groups were not significantly disrupted at 144 hpf compared with the control group, with the exception of a heterogeneous distribution of the cells in inner nuclear cell layer and a significant decrease in the diameters of whole eyes after 8 Gy irradiation. X-Ray radiation at later stages of gastrulation may not cause distinct optic complications; however, there is still a risk of microophthalmia at high doses of irradiation.
出版地LONDON
关键词X-Ray eye development zebrafish cell apoptosis reactive oxygen species microophthalmia
学科领域Toxicology
作者部门
[Zhou, R.;
Si, J.;
Zhang, H.;
Zhou, X.;
Can, L.;
Liu, Y.] Chinese Acad Sci, Inst Modern Phys, Dept Med Phys, Lanzhou 730000, Peoples R China;
[Zhou, R.;
Si, J.;
Zhang, H.;
Zhou, X....更多
DOI10.1177/0960327114522278
文章类型Article
收录类别SCIE
所属项目编号National Basic Research Program of China [2010CB834202] ; National Natural Science Foundation of China [10835011] ; Scientific Technology Research Projects of Gansu Province [0702NKDA045, 0806RJYA020]
语种英语
资助项目国家自然科学基金项目 ; 国家重点基础研究发展计划以及国家重大科学研究计划(973计划) ; 甘肃省青年科技基金计划 ; 甘肃省科技重大专项计划
项目资助者NSFC ; MOST ; GSSTD
WOS记录号WOS:000343382400005
第一机构
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文献类型期刊论文
条目标识符http://ir.lzu.edu.cn/handle/262010/122123
Collection口腔医学院
通讯作者Zhang, H (reprint author), Chinese Acad Sci, Inst Modern Phys, Dept Heavy Ion Radiat Med, Lanzhou 730000, Peoples R China.
Recommended Citation:
GB/T 7714
Zhou, R,Si, J,Zhang, H,et al. The effects of x-ray radiation on the eye development of zebrafish[J]. HUMAN & EXPERIMENTAL TOXICOLOGY,2014,33(10):1040-1050.
APA Zhou, R.,Si, J.,Zhang, H.,Wang, Z.,Li, J.,...&Zhang, H .(2014).The effects of x-ray radiation on the eye development of zebrafish.HUMAN & EXPERIMENTAL TOXICOLOGY,33(10),1040-1050.
MLA Zhou, R,et al."The effects of x-ray radiation on the eye development of zebrafish".HUMAN & EXPERIMENTAL TOXICOLOGY 33.10(2014):1040-1050.
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