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题名: The effects of x-ray radiation on the eye development of zebrafish
作者: Zhou, R; Si, J; Zhang, H; Wang, Z; Li, J; Zhou, X; Can, L; Liu, Y
收录类别: SCIE
出版日期: 2014-10
刊名: HUMAN & EXPERIMENTAL TOXICOLOGY
卷号: 33, 期号:10, 页码:1040-1050
英文摘要: The toxic effects of x-ray radiation on eye development was measured using zebrafish as a model organism. Zebrafish embryos at 8 h post-fertilization (hpf) were irradiated using X-rays at doses of 1, 2, 4, and 8 Gy. At 24 and 48 hpf, x-ray radiation induced a significant increase in reactive oxygen species (ROS) content and cell apoptotic signals. Both of these increases were dose dependent and there were significant positive relationships between them at 24 hpf. At 48 and 72 hpf, the increase of ROS concentration can be eliminated by increasing activities of superoxide dismutase and catalase. Although the ROS generated by x-ray radiation caused a significant increase in cell apoptosis at 24 and 48 hpf, the cellular layers of the retina and lens formation in the irradiated groups were not significantly disrupted at 144 hpf compared with the control group, with the exception of a heterogeneous distribution of the cells in inner nuclear cell layer and a significant decrease in the diameters of whole eyes after 8 Gy irradiation. X-Ray radiation at later stages of gastrulation may not cause distinct optic complications; however, there is still a risk of microophthalmia at high doses of irradiation.
关键词: X-Ray ; eye development ; zebrafish ; cell apoptosis ; reactive oxygen species ; microophthalmia
作者部门: [Zhou, R. ; Si, J. ; Zhang, H. ; Zhou, X. ; Can, L. ; Liu, Y.] Chinese Acad Sci, Inst Modern Phys, Dept Med Phys, Lanzhou 730000, Peoples R China ; [Zhou, R. ; Si, J. ; Zhang, H. ; Zhou, X. ; Can, L. ; Liu, Y.] Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China ; [Zhou, R. ; Si, J. ; Zhang, H. ; Zhou, X. ; Can, L. ; Liu, Y.] Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou, Peoples R China ; [Wang, Z.] Lanzhou Univ, Sch Hosp Stomatol, Lanzhou 730000, Peoples R China ; [Li, J.] Northwest Normal Univ, Coll Life Sci, Lanzhou, Peoples R China
通讯作者: Zhang, H (reprint author), Chinese Acad Sci, Inst Modern Phys, Dept Heavy Ion Radiat Med, Lanzhou 730000, Peoples R China.
学科分类: Toxicology
文章类型: Article
所属项目编号: National Basic Research Program of China [2010CB834202] ; National Natural Science Foundation of China [10835011] ; Scientific Technology Research Projects of Gansu Province [0702NKDA045, 0806RJYA020]
所属项目名称: 国家自然科学基金项目 ; 国家重点基础研究发展计划以及国家重大科学研究计划(973计划) ; 甘肃省青年科技基金计划 ; 甘肃省科技重大专项计划
项目资助者: NSFC ; MOST ; GSSTD
语种: 英语
DOI: 10.1177/0960327114522278
ISSN号: 0960-3271
WOS记录号: WOS:000343382400005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/122123
Appears in Collections:口腔医学院_期刊论文

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