兰州大学机构库 >口腔医学院
Hairy Polyelectrolyte Brushes-Grafted Thermosensitive Microgels as Artificial Synovial Fluid for Simultaneous Biomimetic Lubrication and Arthritis Treatment
Liu, GQ; Liu, ZL; Li, N; Wang, XL; Zhou, F; Liu, WM; Wang, XL (reprint author), Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, Lanzhou 730000, Peoples R China.
收录类别SCIE ; EI
2014-11-26
发表期刊ACS APPLIED MATERIALS & INTERFACES
卷号6期号:22页码:20452-20463
出版者AMER CHEMICAL SOC
出版地WASHINGTON
摘要We report the fabrication of poly(3-sulfopropyl methacrylate potassium salt) (PSPMK) brushes grafted poly(N-isopropylacrylamide) (PNIPAAm) microgels and their potential as artificial synovial fluid for biomimetic aqueous lubrication and arthritis treatment. The negatively charged PSPMK brushes and thermosensitive PNIPAAm microgels play water-based hydration lubrication and temperature-triggered drug release, respectively. Under soft friction pairs, an ultralow coefficient of friction was achieved, while the hairy thermosensitive microgels showed a desirable temperature-triggered drugs release performance. Such a soft charged hairy microgel offers great possibility for designing intelligent synovial fluid. What is more, the combination of lubrication and drug loading capabilities enables the large clinical potential of novel soft hairy nanoparticles as synthetic joint lubricant fluid in arthritis treatment.
关键词hairy microgels polyelectrolyte brushes hydration lubrication biomimetic synovial fluid arthritis treatment
作者部门[Liu, Guoqiang;
Liu, Zhilu;
Wang, Xiaolong;
Zhou, Feng;
Liu, Weimin] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, Lanzhou 730000, Peoples R China;
[Liu, Guoqiang] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China;
[Li, Na] Lanzhou Univ, Sch Hosp Stomatol, Lanzhou 730000, Peoples R China
学科领域Science & Technology - Other Topics ; Materials Science
所属项目编号NSFC [21125316, 21303233, 51335010, 21434009] ; 973 projects [2013CB632300] ; Key Research Program of CAS [KJZD-EW-M01]
资助项目国家自然科学基金项目 ; 国家重点基础研究发展计划以及国家重大科学研究计划(973计划)
项目资助者NSFC ; MOST
DOI10.1021/am506026e
ISSN1944-8244
文章类型Article
语种英语
WOS记录号WOS:000345721400122
EI记录号20145000309326
第一机构
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文献类型期刊论文
条目标识符http://ir.lzu.edu.cn/handle/262010/122124
Collection口腔医学院
通讯作者Wang, XL (reprint author), Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, Lanzhou 730000, Peoples R China.
Recommended Citation:
GB/T 7714
Liu, GQ,Liu, ZL,Li, N,et al. Hairy Polyelectrolyte Brushes-Grafted Thermosensitive Microgels as Artificial Synovial Fluid for Simultaneous Biomimetic Lubrication and Arthritis Treatment[J]. ACS APPLIED MATERIALS & INTERFACES,2014,6(22):20452-20463.
APA Liu, GQ.,Liu, ZL.,Li, N.,Wang, XL.,Zhou, F.,...&Wang, XL .(2014).Hairy Polyelectrolyte Brushes-Grafted Thermosensitive Microgels as Artificial Synovial Fluid for Simultaneous Biomimetic Lubrication and Arthritis Treatment.ACS APPLIED MATERIALS & INTERFACES,6(22),20452-20463.
MLA Liu, GQ,et al."Hairy Polyelectrolyte Brushes-Grafted Thermosensitive Microgels as Artificial Synovial Fluid for Simultaneous Biomimetic Lubrication and Arthritis Treatment".ACS APPLIED MATERIALS & INTERFACES 6.22(2014):20452-20463.
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