口腔医学院机构知识库

Institutional Repository, School of Stomatology

 

兰州大学机构库  > 口腔医学院  > 期刊论文
题名: Hairy Polyelectrolyte Brushes-Grafted Thermosensitive Microgels as Artificial Synovial Fluid for Simultaneous Biomimetic Lubrication and Arthritis Treatment
作者: Liu, GQ; Liu, ZL; Li, N; Wang, XL; Zhou, F; Liu, WM
收录类别: SCIE ; EI
出版日期: 2014-11-26
刊名: ACS APPLIED MATERIALS & INTERFACES
卷号: 6, 期号:22, 页码:20452-20463
英文摘要: We report the fabrication of poly(3-sulfopropyl methacrylate potassium salt) (PSPMK) brushes grafted poly(N-isopropylacrylamide) (PNIPAAm) microgels and their potential as artificial synovial fluid for biomimetic aqueous lubrication and arthritis treatment. The negatively charged PSPMK brushes and thermosensitive PNIPAAm microgels play water-based hydration lubrication and temperature-triggered drug release, respectively. Under soft friction pairs, an ultralow coefficient of friction was achieved, while the hairy thermosensitive microgels showed a desirable temperature-triggered drugs release performance. Such a soft charged hairy microgel offers great possibility for designing intelligent synovial fluid. What is more, the combination of lubrication and drug loading capabilities enables the large clinical potential of novel soft hairy nanoparticles as synthetic joint lubricant fluid in arthritis treatment.
关键词: hairy microgels ; polyelectrolyte brushes ; hydration lubrication ; biomimetic synovial fluid ; arthritis treatment
作者部门: [Liu, Guoqiang ; Liu, Zhilu ; Wang, Xiaolong ; Zhou, Feng ; Liu, Weimin] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, Lanzhou 730000, Peoples R China ; [Liu, Guoqiang] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China ; [Li, Na] Lanzhou Univ, Sch Hosp Stomatol, Lanzhou 730000, Peoples R China
通讯作者: Wang, XL (reprint author), Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, Lanzhou 730000, Peoples R China.
学科分类: Science & Technology - Other Topics; Materials Science
文章类型: Article
所属项目编号: NSFC [21125316, 21303233, 51335010, 21434009] ; 973 projects [2013CB632300] ; Key Research Program of CAS [KJZD-EW-M01]
所属项目名称: 国家自然科学基金项目 ; 国家重点基础研究发展计划以及国家重大科学研究计划(973计划)
项目资助者: NSFC ; MOST
语种: 英语
DOI: 10.1021/am506026e
ISSN号: 1944-8244
WOS记录号: WOS:000345721400122
EI记录号: 20145000309326
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/122124
Appears in Collections:口腔医学院_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
Hairy Polyelectrolyte Brushes-Grafted Thermose.pdf(753KB)----限制开放View 联系获取全文
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Altmetrics Score
 
Google Scholar
Similar articles in Google Scholar
[Liu, GQ]'s Articles
[Liu, ZL]'s Articles
[Li, N]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Liu, GQ]‘s Articles
[Liu, ZL]‘s Articles
[Li, N]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Hairy Polyelectrolyte Brushes-Grafted Thermose.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Email:
Passwd
验 证:
换一张
Have you forgotten your password? Log In
Copyright © 2007-2017  兰州大学 - Feedback
Powered by CSpace