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题名: Preparation and Properties of Biodegradable Composites Derived from Poly(lactide-co-glycolide), Poly(L-lactide), and Nanohydroxyapatite
作者: Chen, X; Zhang, LW; Liu, X; Cui, YJ; Zhao, GH; Li, YF(李彦锋)
收录类别: SCIE
出版日期: 2013
刊名: JOURNAL OF MACROMOLECULAR SCIENCE PART B-PHYSICS
卷号: 52, 期号:3, 页码:462-475
英文摘要: Poly(L-lactide-co-glycolide) (PLGA), poly(L-lactide) (PLLA), and nanohydroxyapatite (HA) were used to prepare a biodegradable bone fixation composite PLGA/PLLA/HA via blending and melt-molding methods. The ratio of PLGA, PLLA, and HA was set to 75.0, 20.0, and 5.0 wt%, respectively, and the neat PLGA and PLGA/PLLA blend were used as controls. Thermal properties were analyzed using thermogravimetric analysis. Mechanical properties, including flexural strength and flexural modulus, were tested before and after degradation. Biodegradability of the resulting PLGA/PLLA/HA composite at the 10th-90th days was analyzed by testing its mass and pH value changes during different degradation periods, as well as by observing its fracture surface morphology changes by scanning electron microscopy. The in vitro cytotoxicity test of the PLGA/PLLA/HA composite was assayed by evaluating the relative growth rate of HEK-293 and Hela cells on sample bars. The results indicate that the resulting PLGA/PLLA/HA composite retained better mechanical properties and degradation behavior than the neat PLGA and PLGA/PLLA blend. Meanwhile, the cytotoxicity test showed that the PLGA/PLLA/HA composite had no obvious cytotoxicity effect.
关键词: biodegradability ; cytotoxicity ; nanohydroxyapatite ; poly(L-lactide) ; poly(L-lactide-co-glycolide)
作者部门: [Chen, Xia ; Liu, Xiao ; Cui, Yanjun ; Zhao, Guanghui ; Li, Yanfeng] Lanzhou Univ, State Key Lab Appl Organ Chem, Coll Chem & Chem Engn, Inst Biochem Engn & Environm Technol, Lanzhou 730000, Peoples R China ; [Zhang, Liwen] Gansu Prov Peoples Hosp, Lanzhou, Peoples R China
通讯作者: Li, YF (reprint author), Lanzhou Univ, State Key Lab Appl Organ Chem, Coll Chem & Chem Engn, Inst Biochem Engn & Environm Technol, Lanzhou 730000, Peoples R China.
学科分类: Polymer Science
文章类型: Article
所属项目编号: Zhonghai Yang Guang Science and Technology Co., Ltd. (Beijing, China)
语种: 英语
DOI: 10.1080/00222348.2012.712007
ISSN号: 0022-2348
WOS记录号: WOS:000341505500002
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/126497
Appears in Collections:化学化工学院_期刊论文

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Recommended Citation:
Chen, X,Zhang, LW,Liu, X,et al. Preparation and Properties of Biodegradable Composites Derived from Poly(lactide-co-glycolide), Poly(L-lactide), and Nanohydroxyapatite[J]. JOURNAL OF MACROMOLECULAR SCIENCE PART B-PHYSICS,2013,52(3):462-475.
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