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题名: New approach to paricalcitol synthesis
作者: Li, LQ; Yue, LR; Xue, JJ; Xie, ZX; Li, Y(李瀛)
收录类别: SCIE ; BIOSIS
出版日期: 2012-05
刊名: CHINESE SCIENCE BULLETIN
卷号: 57, 期号:14, 页码:1616-1619
英文摘要: Paricalcitol, an analog of vitamin D, is used as a drug for the prevention and treatment of secondary hyperparathyroidism. In this paper, a new strategy for the synthesis of paricalcitol is described. This approach includes three main improvements: one-pot regioselective ozonization cleavage of the side-chain and methylene at C-19, free-radical reduction removal of the OH group formed at C-19, and side-chain assembly using a Wittig reaction. These are all new strategies for the synthesis of 19-nor-vitamin D-2 compounds.
关键词: paricalcitol ; synthesis ; ozonization ; Wittig reaction
作者部门: [Li LiQi ; Yue LiRong ; Xue JiJun ; Xie ZhiXiang ; Li Ying] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
通讯作者: Xue, JJ (reprint author), Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China.
学科分类: Science & Technology - Other Topics
文章类型: Article
所属项目编号: National Natural Science Foundation of China [20802028, 21072084]
所属项目名称: 国家自然科学基金项目
项目资助者: NSFC
语种: 英语
DOI: 10.1007/s11434-011-4915-z
ISSN号: 1001-6538
WOS记录号: WOS:000303388600003
BIOSIS记录号: BIOSIS:PREV201200396316
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/126537
Appears in Collections:化学化工学院_期刊论文

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Recommended Citation:
Li, LQ,Yue, LR,Xue, JJ,et al. New approach to paricalcitol synthesis[J]. CHINESE SCIENCE BULLETIN,2012,57(14):1616-1619.
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