口腔医学院机构知识库

Institutional Repository, School of Stomatology

 

兰州大学机构库  > 口腔医学院  > 期刊论文
题名: 混合阳离子交联剂甲基丙烯酸海藻酸盐微球的构建及其性能研究
其他题名: Preparation and properties evaluation of methacrylic alginate gell beads cross-linked by mixed metal-cation
作者: 樊星; 雷胜男; 任利玲
收录类别: MEDLINE ; CSCD
出版日期: 2013-12-25
刊名: 生物医学工程学杂志/Journal of biomedical engineering
卷号: 30, 期号:6, 页码:1272-1275
中文摘要: 本研究旨在制备既有一定机械强度又能保持良好渗透性的海藻酸盐凝胶小球,从而可更好地应用于组织工程领域。通过海藻酸盐中的羧基和甲基丙烯酸中的氨基作用生成酰胺键的反应,将甲基丙烯酸引入藻酸盐长链,然后利用热反应的原理,通过甲基丙烯酸中的双键聚合,使藻酸盐长链的强度得以增强,最后将氯化钙和氯化钡分别以7∶3、5∶5、3∶7比例混和作为阳离子交联剂,形成海藻酸盐凝胶小球,并进一步研究其压缩模量和渗透性。结果表明以[Ba2+:Ca2+=5∶5]作为混合阳离子交联剂制作的凝胶小球,压缩模量为189.7kPa,对24kDa的胰蛋白酶分子的渗透性最好,对67kDa的牛血清白蛋白分子具有截留作用。以[Ba2+:C...
英文摘要: The aim of this study was to obtain the alginate gels which could have proper compressive strength and excellent permeability for cell proliferation and could have more promising potentials in the application of tissue engineering. Through the reaction of the carboxyl of the alginate and the amino of methacrylic acid, methylacrylic was generated into alginate long chain which could be enhanced by the polymerization of double bond under thermal reaction condition. And then alginate gel beads were prepared using the mixture of calcium chloride and barium chloride solution as cationic crosslinker, and the compressive modulus and permeability of the prepared alginate gel beads were investigated. When the ratio of barium ions to calcium ions was 5:5, the compression modulus was 189.7 kPa, and it showed the best permeability for trypsin with molecular weight of 24 kDa and entrapment effect for bovine serum albumin with molecular weight of 67 kDa. Compared to compositions of other ratios, the alginate gel beads made in 5:5 mixture indicated excellent compressive modulus and permeability. These results indicated that the alginate hydrogel beads with the ratio of barium ions to calcium ions being 5:5 have a potential application in tissue engineering as a support material and encapsulating materials in cell culture.
关键词: 海藻酸钠 ; 甲基丙烯酸藻酸盐 ; 凝胶小球 ; 渗透性 ; 阳离子交联剂
作者部门: 兰州大学口腔医学院
学科分类: Biochemistry & Molecular Biology; Cell Biology
所属项目编号: 兰州大学中央高校基本科研业务费专项资金资助项目(LZU-JBKY-2010-141)
所属项目名称: 中央高校基本科研业务费专项资金
项目资助者: LZU
语种: 中文
ISSN号: 1001-5515
CSCD记录号: CSCD:5015238
PM记录号: 24645610
IR记录号: CNKI:0055545
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/158833
Appears in Collections:口腔医学院_期刊论文

Files in This Item:

There are no files associated with this item.


Recommended Citation:
樊星,雷胜男,任利玲. 混合阳离子交联剂甲基丙烯酸海藻酸盐微球的构建及其性能研究[J]. 生物医学工程学杂志/Journal of biomedical engineering,2013,30(6):1272-1275.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Altmetrics Score
 
Google Scholar
Similar articles in Google Scholar
[樊星]'s Articles
[雷胜男]'s Articles
[任利玲]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[樊星]‘s Articles
[雷胜男]‘s Articles
[任利玲]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Email:
Passwd
验 证:
换一张
Have you forgotten your password? Log In
Copyright © 2007-2017  兰州大学 - Feedback
Powered by CSpace