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题名: SF/COL/PLLA静电纺丝三维纳米纤维支架材料的性能研究
其他题名: A research on the performance of SF/COL/PLLA electrospun three-dimensiona nanofiber scaffold
作者: 张忠芮; 王红; 高维岳; 王家奎; 黄嵩涛; 殷丽华; 王琳; 余占海
收录类别: EI ; CSCD
出版日期: 2014-07-15
刊名: 功能材料/Gongneng Cailiao/Journal of Functional Materials
卷号: 45, 期号:14, 页码:14081-14086
中文摘要: 基于PLLA(左旋聚乳酸)的优异性能,以六氟异丙醇(HFIP)为溶剂采用静电纺丝法制备质量比为0∶100,30∶70,50∶50,70∶30和100∶0的8%SF/COL/PLLA共混纳米纤维支架,并用浓度为25%戊二醛蒸汽交联48h,通过扫描电镜、X射线衍射、热重分析仪、接触角检测仪对共混材料交联前后的理化性能进行表征。结果表明纳米纤维直径均一,分布均匀;交联后SilkI形成稳定的β折叠,结晶度增强,且交联后材料结晶度明显较交联前增强;热稳定性也随着PLLA浓度的增加愈加稳定。交联后的材料接触角均大于90°表明材料为疏水性,PLLA的加入降低了材料的亲水性能。复合人牙周膜干细胞和材料培养,分...
英文摘要: The aim of this study was to prepare a kind of nanofiber scaffolds composed of different mass ratios of silkfibroin(SF)/collagen/PLLA by using electrospinning technique and to evaluate its properties. 1, 1, 1, 3, 3, 3-hexafluoro-2-propanol (HFIP)was taken as solvent to prepare the nanofiber scaffolds and the mass ratios of SF/collagen/PLLA were set as 0:100, 30:70, 50:50, 70:30, 100:0. And then the preoperties of the as-prepared samples were tested before and after crosslinked by 25% glutaraldehyde vapor for 48 h. The scaffolds were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), thermo gravimetric (TG) analysis and the hydrophily was analysed by water contact angle (WCA) analysis. The results of SEM revealed that the uniformity of the blending nanofibers had improved. The thermal stability of the scaffold material increased with the increase of the blend ratios of PLLA. The XRD results indicated that stable β-folding conformation of silk has formed and the crystallization of materials has increased. The contact water angle meter analysis suggested that the hydrophilic property of the blending composite nanofibers decreased with the existence of PLLA. The periodontal ligament stem cells (PDLSCs) were seeded on the blending composite nanofibers in vitro. The cells grew well on the surface of materials, and had great adhesion and proliferation abilities. The cytocompatibility and physicochemical properties of the scaffold with content of 70% PLLA are superior to other groups, which suggest the as-prepared sampleis expected to become a new type of scaffold forperiodontal tissue engineering.
关键词: 静电纺丝 ; 三维纳米支架 ; 聚左旋乳酸 ; 理化性能 ; 生物性能 ; Biological properties ; Composite nanofibers ; Electrospinning techniques ; Hydrophilic properties ; Physicochemical property ; Poly lactic acid ; Surface of materials ; Water contact angle (WCA)
作者部门: 兰州大学口腔医学院
通讯作者: Yu, Z.-H. (yuzhanhai@lzu.edu.cn)
学科分类: Biomedical Engineering; Biological Materials and Tissue Engineering; Light/Optics; Nanotechnology; Chemical Operations; Fiber Chemistry and Processing; Solid State Physics; Crystal Lattice
所属项目编号: 国家自然科学基金青年科学基金资助项目(81102712)
所属项目名称: 国家自然科学基金项目
项目资助者: NSFC
语种: 中文
DOI: 10.3969/j.issn.1001-9731.2014.14.016
ISSN号: 10019731
CSCD记录号: CSCD:5216401
EI记录号: 20143318074354
IR记录号: CNKI:0005388
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/158891
Appears in Collections:口腔医学院_期刊论文

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Recommended Citation:
张忠芮,王红,高维岳,等. SF/COL/PLLA静电纺丝三维纳米纤维支架材料的性能研究[J]. 功能材料/Gongneng Cailiao/Journal of Functional Materials,2014,45(14):14081-14086.
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