兰州大学机构库 >基础医学院
蛇葡萄素钠协同卡铂体外诱导人肺腺癌GLC-82细胞凋亡研究
张艳霞; 吴勇杰; 李文广
Indexed ByCSCD
2014-08-15
Source Publication中药药理与临床
Volume30Issue:4Pages:26-29
Host of Journal中国药理学会 ; 四川省中医药科学院
Publication PlaceCHENGDU
Abstract目的:考察蛇葡萄素钠单用及与卡铂合用对人肺腺癌GLC-82细胞增值的抑制作用,初步探讨蛇葡萄素钠抑瘤作用机制。方法:应用MTT法考察蛇葡萄素钠单用及与卡铂合用对人肺腺癌GLC-82细胞的细胞毒作用;使用流式细胞仪检测凋亡相关基因Bax以及Bcl-2表达。结果:MTT实验结果表明,蛇葡萄素钠单独应用及与卡铂联合应用对GLC-82细胞的增殖均具有浓度依赖性的抑制作用;流式细胞仪检测结果表明,蛇葡萄素钠(100、50、25μg/ml)单用组及与卡铂25μg/ml联合用药组作用于GLC-82细胞48 h后,Bax表达上调,且有浓度依赖性;AMP-Na 50μg/ml单独用药组、卡铂25μg/ml单独用...
Keyword蛇葡萄素钠 卡铂 人肺腺癌GLC-82细胞 细胞凋亡 Bcl-2 Bax
Department甘肃中医学院;
兰州大学基础医学院药理学研究所甘肃省新药临床前研究重点实验室
ISSN1001-859X
Language中文
CSCD IDCSCD:5260989
IRIDCNKI:0005325
First Inst
Citation statistics
Cited Times:6[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.lzu.edu.cn/handle/262010/164038
Collection基础医学院
Recommended Citation
GB/T 7714
张艳霞,吴勇杰,李文广. 蛇葡萄素钠协同卡铂体外诱导人肺腺癌GLC-82细胞凋亡研究[J]. 中药药理与临床,2014,30(4):26-29.
APA 张艳霞,吴勇杰,&李文广.(2014).蛇葡萄素钠协同卡铂体外诱导人肺腺癌GLC-82细胞凋亡研究.中药药理与临床,30(4),26-29.
MLA 张艳霞,et al."蛇葡萄素钠协同卡铂体外诱导人肺腺癌GLC-82细胞凋亡研究".中药药理与临床 30.4(2014):26-29.
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