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题名: Initiating Characteristics of Early-onset Type 2 Diabetes Mellitus in Chinese Patients
作者: Yu, H; Xie, LF; Chen, K; Yang, GY; Xing, XY; Zhao, JJ; Hong, TP; Shan, ZY; Li, HM; Chen, B; Tang, XL; Qi, L; Yang, J; Fang, Y; Li, T; Wang, SS; Liang, X; Yin, YQ; Mu, YM
收录类别: SCIE ; PubMed ; MEDLINE ; CSCD
出版日期: 2016-04-05
刊名: CHINESE MEDICAL JOURNAL
卷号: 129, 期号:7, 页码:778-784
期刊主办单位: 中华医学会
出版者: MEDKNOW PUBLICATIONS
出版地: MUMBAI
英文摘要: Background: Type 2 diabetes mellitus (T2DM) has traditionally been considered to affect mainly the elderly; however, the age at diagnosis has gradually reduced in recent years. Although the incidence of young-onset T2DM is increasing, it is still not fully clear the onset characteristics and risk factors of early-onset T2DM. The aim of this study was to describe the initiating characteristics of early-onset T2DM in Chinese patients and evaluate the risk factors for diabetes mellitus. Methods: This cross-sectional controlled study was performed using a questionnaire survey method in outpatients of multiple centers in China. A total of 1545 patients with T2DM with an age at onset of <40 years were included, and the control group consisted of subjects aged <40 years with normal blood glucose level. Results: In patients with young-onset T2DM, the mean age and initial hemoglobin 1Ac at diagnosis were 32.96 +/- 5.40 years and 9.59 +/- 2.71%, respectively. Most of the patients were obese, followed irregular diet pattern and sedentary lifestyle, had life or work pressure, and had a family history of diabetes mellitus. Compared with subjects with normal blood glucose level, logistic regression analysis showed that waist-to-hip ratio (odds ratio [OR] 446.99, 95% confidence interval [CI] 42.37-4714.87), family history of diabetes mellitus (OR 23.46, CI 14.47-38.03), dyslipidemia (OR 2.65, CI 1.54-4.56), diastolic blood pressure (OR 1.02, CI 1.00-1.04), and body mass index (OR 0.95, CI 0.92-0.99) are independent factors for early-onset T2DM. Conclusions: We observed that abdominal obesity, family history of diabetes mellitus, and medical history of hypertension and dyslipidemia are independent risk factors for early-onset T2DM. It is, therefore, necessary to apply early lifestyle intervention in young people with risk of diabetes mellitus.
关键词: Obesity ; Risk Factor ; Type 2 Diabetes Mellitus ; Young
作者部门: [Yu, Hui ; Chen, Kang ; Li, Ting ; Wang, Shuang-Shuang ; Liang, Xue ; Yin, Ya-Qi ; Mu, Yi-Ming] Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, 28 Fuxing Rd, Beijing 100853, Peoples R China ; [Xie, Li-Fang] Chinese Peoples Liberat Army 155 Hosp, Dept Endocrinol, Kaifeng 475003, Henan, Peoples R China ; [Yang, Gang-Yi] Chongqing Med Univ, Affiliated Hosp 2, Dept Endocrinol, Chongqing 400010, Peoples R China ; [Xing, Xiao-Yan] China Japan Friendship Hosp, Dept Endocrinol, Beijing 100029, Peoples R China ; [Zhao, Jia-Jun] Shandong Univ, Shandong Prov Hosp, Dept Endocrinol & Metab, Jinan 250021, Shandong, Peoples R China ; [Hong, Tian-Pei] Peking Univ, Hosp 3, Dept Endocrinol, Beijing 100191, Peoples R China ; [Shan, Zhong-Yan] China Med Univ, Affiliated Hosp 1, Liaoning Prov Key Lab Endocrine Dis, Dept Endocrinol & Metab,Inst Endocrinol, Shenyang 110001, Liaoning, Peoples R China ; [Li, Hong-Mei] China Meitan Gen Hosp, Dept Endocrinol, Beijing 100028, Peoples R China ; [Chen, Bing] Third Mil Med Univ, Southwest Hosp, Dept Endocrinol & Metab, Chongqing 400038, Peoples R China ; [Tang, Xu-Lei] Lanzhou Univ, Dept Endocrinol, Affiliated Hosp 1, Lanzhou 730000, Gansu, Peoples R China ; [Qi, Ling] Beijing Yanhua Hosp, Dept Endocrinol, Beijing 102500, Peoples R China ; [Yang, Jing] Shanxi Med Univ, Hosp 1, Dept Endocrinol, Taiyuan 030001, Shanxi, Peoples R China ; [Fang, Yuan] Capital Med Univ, Beijing Luhe Hosp, Dept Endocrinol, Beijing 101100, Peoples R China
通讯作者: Mu, YM (reprint author), Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, 28 Fuxing Rd, Beijing 100853, Peoples R China.
学科分类: General & Internal Medicine
文章类型: Article
所属项目编号: National Science and Technology Major Project [2011ZX09307-001-08]
所属项目名称: 国家科技重大专项
项目资助者: MOST
语种: 英语
DOI: 10.4103/0366-6999.178959
ISSN号: 0366-6999
WOS记录号: WOS:000373387000004
CSCD记录号: CSCD:5674625
PM记录号: 26996471
IR记录号: WOS:000373387000004
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/178639
Appears in Collections:第一临床医学院_期刊论文

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Recommended Citation:
Yu, H,Xie, LF,Chen, K,et al. Initiating Characteristics of Early-onset Type 2 Diabetes Mellitus in Chinese Patients[J]. CHINESE MEDICAL JOURNAL,2016,129(7):778-784.
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