兰州大学机构库 >基础医学院
The Effect of Calcium Sodium Phosphosilicate on Dentin Hypersensitivity: A Systematic Review and Meta-Analysis
Zhu, MJ; Li, JL; Chen, B; Mei, L; Yao, L; Tian, JH(田金徽); Li, H; Li, H (reprint author), Nanjing Univ, Sch Med, Nanjing Stomatol Hosp, Dept Oral Sci, Nanjing, Jiangsu, Peoples R China.
Indexed BySCIE ; PubMed ; MEDLINE
2015-11-06
Source PublicationPLOS ONE
Volume10Issue:11
PublisherPLOS
Publication PlaceSAN FRANCISCO
AbstractObjective To investigate the effect of calcium sodium phosphosilicate (CSPS) in treating dentin hypersensitivity (DH) and to compare this effect to that of a negative (placebo) control. Materials and Methods Several databases, including Medline, EMBASE, Web of Science, The Cochrane Library, and the Chinese Biomedical Literature Database, were searched to identify relevant articles published through January 2015; grey literature (i.e., academic literature that is not formally published) was also searched. Two authors performed data extraction independently and jointly using data collection forms. The primary outcome was the DH pain response to routine activities or to thermal, tactile, evaporative, or electrical stimuli, and the secondary outcome was the side effects of CSPS use. Each study was evaluated using the Cochrane Collaboration tool for assessing risk bias. Meta-analysis of studies with the same participant demographics, interventions, controls, assessment methods and follow-up periods was performed. The Grading of Recommendations Assessment Development and Evaluation System was used to assess the quality of the evidence and the risk of bias across studies. Results Meta-analysis demonstrated that toothpaste containing 5% CSPS was more effective than the negative control at relieving dentin sensitivity, with the level of evidence classified as "moderate". In addition, prophylaxis paste containing 15% calcium sodium phosphosilicate was favored over the negative control at reducing post-periodontal therapy hypersensitivity, with the level of evidence categorized as "low". Only two studies reported side effects of CSPS use. Conclusions The majority of studies found that calcium sodium phosphosilicate was more effective than the negative control at alleviating DH. Because strong evidence is scarce, high-quality, well-designed clinical trials are required in the future before definitive recommendations can be made.
Department[Zhu, Mengjiao;
Li, Huang] Nanjing Univ, Sch Med, Nanjing Stomatol Hosp, Dept Oral Sci, Nanjing, Jiangsu, Peoples R China;
[Chen, Bin] Nanjing Univ, Sch Med, Nanjing Stomatol Hosp, Dept Periodont, Nanjing, Jiangsu, Peoples R China;
[Mei, Li] Univ Otago, Fac Dent, Dept Oral Sci, Discipline Orthodont, Dunedin, New Zealand;
[Yao, Liang;
Tian, Jinhui] Lanzhou Univ, Sch Basic Med Sci, Evidence Based Med Ctr, Lanzhou 730000, Gansu, Peoples R China
Subject AreaScience & Technology - Other Topics
Project NumberNational Natural Science Foundation of China [81470712, 81070807]
Funding Project国家自然科学基金项目
Funding OrganizationNSFC
DOI10.1371/journal.pone.0140176
ISSN1932-6203
SubtypeArticle
Language英语
WOS IDWOS:000364398700005
PMID 26544035
IRIDWOS:000364398700005
First Inst
Citation statistics
Document Type期刊论文
Identifierhttp://ir.lzu.edu.cn/handle/262010/179076
Collection基础医学院
Corresponding AuthorLi, H (reprint author), Nanjing Univ, Sch Med, Nanjing Stomatol Hosp, Dept Oral Sci, Nanjing, Jiangsu, Peoples R China.
Recommended Citation
GB/T 7714
Zhu, MJ,Li, JL,Chen, B,et al. The Effect of Calcium Sodium Phosphosilicate on Dentin Hypersensitivity: A Systematic Review and Meta-Analysis[J]. PLOS ONE,2015,10(11).
APA Zhu, MJ.,Li, JL.,Chen, B.,Mei, L.,Yao, L.,...&Li, H .(2015).The Effect of Calcium Sodium Phosphosilicate on Dentin Hypersensitivity: A Systematic Review and Meta-Analysis.PLOS ONE,10(11).
MLA Zhu, MJ,et al."The Effect of Calcium Sodium Phosphosilicate on Dentin Hypersensitivity: A Systematic Review and Meta-Analysis".PLOS ONE 10.11(2015).
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