兰州大学机构库 >基础医学院
Catalytic Desymmetrization of meso-Aziridines with Benzofuran-2(3H)-Ones Employing a Simple In Situ-Generated Magnesium Catalyst
Li, D; Wang, LQ; Yang, DX; Zhang, BZ(张邦治); Wang, R(王锐); Zhang, BZ (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Sch Basic Med Sci, Lanzhou 730000, Peoples R China.
Indexed BySCIE ; EI
2015-12
Source PublicationACS CATALYSIS
Volume5Issue:12Pages:7432-7436
PublisherAMER CHEMICAL SOC
Publication PlaceWASHINGTON
AbstractThe first example of catalytic desymmetrization of meso-aziridines with benzofuran-2(3H) -ones is realized by employing a magnesium catalyst utilizing BINOL as a simple and commercially available chiral ligand. Both of the enantiomers of the ring-opening product could be easily accessed by employing (R)- or (S)-BINOL as chiral ligand, respectively. A variety of enantioenriched 3,3disubstituted benzofuran-2(3H)-ones containing multiple linear continuous stereocenters were obtained with moderate to good yields, diastereo- and enantioselectivities.
Keyworddesymmetrization meso-aziridines benzofuran-2(3H)-ones magnesium catalyst BINOL
Department[Li, Dan;
Wang, Linqing;
Yang, Dongxu;
Zhang, Bangzhi;
Wang, Rui] Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Sch Basic Med Sci, Lanzhou 730000, Peoples R China
Subject AreaChemistry
Project NumberNSFC [21432003, 91413107, 81473095, 81202400] ; National S&T Major Project of China [2012ZX09504001-003] ; Program for Chang-jiang Scholars and Innovative Research Team in University [PCSIRT: IRT_15R27] ; Innovation Group of Gansu Province [1210RJIA002, 1304FKCA084]
Funding Project国家自然科学基金项目 ; 国家科技重大专项 ; 长江学者和创新团队发展计划 ; 甘肃省科技支撑计划 ; 甘肃省创新研究群体计划
Funding OrganizationNSFC ; MOST ; MOE ; GSSTD
DOI10.1021/acscatal.5b02177
ISSN2155-5435
SubtypeArticle
Language英语
WOS IDWOS:000366153300043
EI ID20154901650694
IRIDWOS:000366153300043
First Inst
Citation statistics
Document Type期刊论文
Identifierhttp://ir.lzu.edu.cn/handle/262010/179080
Collection基础医学院
Corresponding AuthorZhang, BZ (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Sch Basic Med Sci, Lanzhou 730000, Peoples R China.
Recommended Citation
GB/T 7714
Li, D,Wang, LQ,Yang, DX,et al. Catalytic Desymmetrization of meso-Aziridines with Benzofuran-2(3H)-Ones Employing a Simple In Situ-Generated Magnesium Catalyst[J]. ACS CATALYSIS,2015,5(12):7432-7436.
APA Li, D,Wang, LQ,Yang, DX,Zhang, BZ,Wang, R,&Zhang, BZ .(2015).Catalytic Desymmetrization of meso-Aziridines with Benzofuran-2(3H)-Ones Employing a Simple In Situ-Generated Magnesium Catalyst.ACS CATALYSIS,5(12),7432-7436.
MLA Li, D,et al."Catalytic Desymmetrization of meso-Aziridines with Benzofuran-2(3H)-Ones Employing a Simple In Situ-Generated Magnesium Catalyst".ACS CATALYSIS 5.12(2015):7432-7436.
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