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题名: Radiosensitization of oral tongue squamous cell carcinoma by nanosecond pulsed electric fields (nsPEFs)
作者: Guo, Jinsong; Wang, Yu; Wang, J(王静); Zhang, Jue; Fang, Jing
收录类别: SCIE ; EI ; MEDLINE
出版日期: 2017-02-01
刊名: Bioelectrochemistry
卷号: 113, 页码:35-41
出版者: ELSEVIER
出版地: LAUSANNE
英文摘要: Nanosecond pulsed electric fields (nsPEFs) are a non-thermal and non-toxic technology that induce a myriad of biological effects. They have been proven to be effective in tumor shrinkage, but few studies focus on its radiosensitization in oral tongue squamous cell carcinoma. The purpose of this research was to study the radiosensitization effect of nsPEFs on a human oral tongue cancer cell line Tca8113 and to investigate the potential antitumor mechanism. A Tca8113 cell line was tested respectively by MIT assay, clonogenic assay, flow cytometry assay, annexin V-FITC/PI assay, mitochondrial potential assay and total nitric oxide assay. Our results showed that nsPEFs had a time and field strength dependent inhibition effect on Tca8113 cells. The sensitization enhancement ratio (SER) of nsPEFs was 1.453 +/- 0.038. Furthermore, radiation induced G2/M arrest was augmented by treatment with nsPEFs. We observed many more Tca8113 cells showing early apoptosis after nsPEFs combined with radiotherapy. Additionally, the NO concentration was significantly increased after nsPEFs treatment. These findings indicate that combination of nsPEFs with radiotherapy can enhance the radiosensitivity of Tca8113 cells and nsPEFs could be a potential radiosensitizer for oral tongue squamous cell carcinoma. (C) 2016 Elsevier B.V. All rights reserved.
关键词: Radiosensitization ; nsPEFs ; TSCC ; G2/M arrest ; Nitric oxide ; Apoptosis
作者部门: (1) College of Engineering, Peking University, Beijing ; 100871, China ; (2) Academy of Advanced Interdisciplinary Studies, Peking University, Beijing ; 100871, China ; (3) Department of Oral Medicine, School of Stomatology, Lanzhou University, Lanzhou ; Gansu, China
通讯作者: Zhang, J (reprint author), Peking Univ, Coll Engn, Beijing 100871, Peoples R China. ; Wang, J (reprint author), Lanzhou Univ, Sch Stomatol, Dept Oral Med, Lanzhou, Gansu, Peoples R China.
学科分类: Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Biophysics; Electrochemistry
文章类型: Article
所属项目编号: Fundamental Research Funds for the Central Universities [lzujbky-2014-159] ; National Natural Science Foundation of China [81372893] ; Natural Science Foundation of Gansu Province [1208RJZA193] ; Peking University Biomed-X Foundation
所属项目名称: 国家自然科学基金项目 ; 中央高校基本科研业务费专项资金 ; 甘肃省自然科学基金计划
项目资助者: NSFC ; LZU ; GSSTD
语种: 英语
DOI: 10.1016/j.bioelechem.2016.09.002
ISSN号: 1567-5394
WOS记录号: WOS:000389165100006
EI记录号: 20163902852264
PM记录号: 27676191
IR记录号: 20163902852264
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/179511
Appears in Collections:口腔医学院_期刊论文

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Recommended Citation:
Guo, Jinsong,Wang, Yu,Wang, Jing,et al. Radiosensitization of oral tongue squamous cell carcinoma by nanosecond pulsed electric fields (nsPEFs)[J]. Bioelectrochemistry,2017,113:35-41.
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