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题名: Reproductive factors and risk of type 2 diabetes in an occupational cohort of Chinese women
作者: Yang, AM; Liu, SM; Cheng, N; Pu, HQ; Dai, M; Ding, J; Li, JS; Li, HY; Hu, XB; Ren, XW; He, J; Zheng, TZ; Bai, YN(白亚娜)
收录类别: SCIE ; PubMed ; BIOSIS
出版日期: 2016-09-10
刊名: JOURNAL OF DIABETES AND ITS COMPLICATIONS
卷号: 30, 期号:7, 页码:1217-1222
出版者: ELSEVIER
出版地: NEW YORK
英文摘要: Aims: Hormonal milieu has long been known to play an important role in the development of type 2 diabetes (T2D). The aims of this study are to investigate the roles of menstrual and reproductive factors in relation to T2D risk in an occupational cohort of Chinese women; and to explore the role of endogenous estrogen in T2D development. Methods: We conducted a cross-sectional analysis of baseline data from 16114 women (11051 premenopausal and 5063 postmenopausal) aged >= 20 years who participated in the ongoing prospective occupational cohort study. Multivariable logistic regressions were modeled to evaluate the associations of reproductive factors with T2D risk. Results: Early menarche at age (<= 12 versus 15-16 years) was associated with increased T2D risk (odds ratio [OR]: 1.60, 95% confidence interval [CI]: 1.16-2.22). After multiple adjustment including age, BMI and occupation, postmenopausal status was positively associated with T2D risk (OR: 1.54, 95% CI: 1.10-2.14). Reproductive life span was significantly associated with T2D risk (P = 0.02), albeit displaying a U-shape relationship. Similarly, age at menopause was also associated with T2D risk in the same U-shaped as with reproductive life span (P = 0.03). Further, years since menopause (P = 0.003), but not history of cycle regularity and hormone use, was associated with increased T2D risk. Conclusion: Reproductive factors were associated with T2D supporting the notion that either a short or prolonged exposure to endogenous estrogen affects T2D risk in Chinese women. Reproductive factors should be added to risk stratification when counseling women about their risk of developing diabetes. (C) 2016 Elsevier Inc. All rights reserved.
关键词: Menarche ; Menopause ; Type 2 diabetes ; Reproduction ; Risk factors
作者部门: [Yang, Aimin ; Li, Juansheng ; Hu, Xiaobin ; Ren, Xiaowei ; Bai, Yana] Lanzhou Univ, Sch Publ Hlth, Dept Epidemiol & Stat, South Donggang Xi Rd 199, Lanzhou 730000, Gansu, Peoples R China ; [Yang, Aimin ; Liu, Simin ; Zheng, Tongzhang] Brown Univ, Sch Publ Hlth, Dept Epidemiol, 121 South Main St, Providence, RI 02912 USA ; [Liu, Simin] Brown Univ, Rhode Isl Hosp, Dept Med Endocrinol, Providence, RI 02901 USA ; [Liu, Simin] Brown Univ, Alpert Med Sch, Providence, RI 02901 USA ; [Cheng, Ning] Lanzhou Univ, Ctr Med Lab, Lanzhou 730000, Gansu, Peoples R China ; [Pu, Hongquan ; Ding, Jiao ; Li, Haiyan] Jinchuan Grp Co Ltd, Workers Hosp, Jinchang 737103, Gansu, Peoples R China ; [Dai, Min ; He, Jie] Chinese Acad Med Sci, Canc Hosp, Beijing 100021, Peoples R China
通讯作者: Bai, YN (reprint author), Lanzhou Univ, Sch Publ Hlth, Dept Epidemiol & Stat, South Donggang Xi Rd 199, Lanzhou 730000, Gansu, Peoples R China. ; Zheng, TZ (reprint author), Brown Univ, Sch Publ Hlth, Dept Epidemiol, 121 South Main St, Providence, RI 02912 USA.
学科分类: Endocrinology & Metabolism
文章类型: Article
所属项目编号: US National Institutes of Health [D43TW 008323, D43TW 007864-01, DK66401] ; American Heart Association ; Project of Employees Health Status and Disease Burden Trend Study in Jinchang Nonferrous Metals Corporation [JKB20120013] ; China Scholarship Council [201406180021]
所属项目名称: 国家留学基金委项目 ; 美国国立卫生研究院项目
项目资助者: CSC ; NIH
语种: 英语
DOI: 10.1016/j.jdiacomp.2016.06.011
ISSN号: 1056-8727
WOS记录号: WOS:000382097600003
PM记录号: 27345735
BIOSIS记录号: BCI:BCI201600765981
IR记录号: WOS:000382097600003
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/179635
Appears in Collections:公共卫生学院_期刊论文

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Recommended Citation:
Yang, AM,Liu, SM,Cheng, N,et al. Reproductive factors and risk of type 2 diabetes in an occupational cohort of Chinese women[J]. JOURNAL OF DIABETES AND ITS COMPLICATIONS,2016,30(7):1217-1222.
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