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兰州大学机构库  > 化学化工学院  > 期刊论文
题名: Triple-Emitting Dumbbell Fluorescent Nanoprobe for Multicolor Detection and Imaging Applications
作者: Liu, J; Liu, J; Liu, WS(刘伟生); Zhang, HL(张浩力); Yang, ZY(杨正银); Wang, BD(汪宝堆); Chen, FJ(陈凤娟); Chen, HT
收录类别: SCIE ; PubMed ; MEDLINE
出版日期: 2015-08-17
刊名: INORGANIC CHEMISTRY
卷号: 54, 期号:16, 页码:7725-7734
出版者: AMER CHEMICAL SOC
出版地: WASHINGTON
英文摘要: The combination of different fluorescent species into one nanostructure to develop fluorescent nanoparticles with multiple emission signatures by a single wavelength excitation has become a very popular research area in the field of multiplex bioanalysis, diagnostics, and multicolor imaging. However, these novel hybrids must be elaborately designed to ensure that the unique properties of each component are conveyed, i.e., fluorescent species and nanoparticles, and are maximized without serious interactions with each other. Herein, a first triple-fluorescence dumbbell nanoprobe with large Stokes shift based on incorporating fluorescein isothiocyanate (FITC) and lanthanide complexes onto Au-Fe3O4 NPs was synthesized. This hybrid displays well-resolved triple fluorescence emission, with FITC at 515 nm, Tb(III) complex at 545 nm, and Eu(III) complex at 616 run under a single-excitation wavelength and is used for highly selective and sensitive colorimetric detection of Cu2+ with a detection limit of 30 nM. Under different Cu2+ concentrations, this hybrid exhibited distinguishable multiple colors under UV light, and the color could change in the presence of different concentrations of Cu2+. This sensor for ratio/multianalyte microscopic imaging of Cu2+ in HeLa cells and BHK cells was also demonstrated. Target molecules, such as folic acid, can be covalently attached to the fluorescent nanoparticle surface to serve as an effective probe for simultaneous multicolor imaging folate receptor-overexpressing HeLa cell lines in vitro.
作者部门: [Liu, Jing ; Liu, Jian ; Liu, Weisheng ; Zhang, Haoli ; Yang, Zhengyin ; Wang, Baodui ; Chen, Fengjuan] Lanzhou Univ Gansu, Key Lab Nonferrous Met Chem & Resources Utilizat, State Key Lab Appl Organ Chem, Minist Educ, Lanzhou 730000, Peoples R China ; [Liu, Jing ; Liu, Jian ; Liu, Weisheng ; Zhang, Haoli ; Yang, Zhengyin ; Wang, Baodui ; Chen, Fengjuan] Lanzhou Univ Gansu, Minist Educ, Key Lab Special Funct Mat & Struct Design, Lanzhou 730000, Peoples R China ; [Chen, Haotai] Chinese Acad Agr Sci, Lanzhou Vet Res Inst, State Key Lab Vet Etiol Biol, Natl Foot & Mouth Dis Reference Lab China, Lanzhou 730046, Gansu, Peoples R China
通讯作者: Wang, BD (reprint author), Lanzhou Univ Gansu, Key Lab Nonferrous Met Chem & Resources Utilizat, State Key Lab Appl Organ Chem, Minist Educ, Lanzhou 730000, Peoples R China.
学科分类: Chemistry
文章类型: Article
所属项目编号: National Natural Science Foundation of China [21271093, 21431002, 21401091] ; National Basic Research Program of China (973 Program) [2012CB933102] ; Program for New Century Excellent Talents in University [NCET-13-0262] ; Fundamental Research Funds for the Central Universities [lzujbky-2014-k06]
所属项目名称: 国家自然科学基金项目 ; 国家重点基础研究发展计划以及国家重大科学研究计划(973计划) ; 新世纪优秀人才支持计划 ; 中央高校基本科研业务费专项资金
项目资助者: NSFC ; MOST ; MOE ; LZU
语种: 英语
DOI: 10.1021/acs.inorgchem.5b00610
ISSN号: 0020-1669
WOS记录号: WOS:000359824400008
PM记录号: 26237056
IR记录号: WOS:000359824400008
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/180143
Appears in Collections:化学化工学院_期刊论文

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Recommended Citation:
Liu, J,Liu, J,Liu, WS,et al. Triple-Emitting Dumbbell Fluorescent Nanoprobe for Multicolor Detection and Imaging Applications[J]. INORGANIC CHEMISTRY,2015,54(16):7725-7734.
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