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题名: Synthesis and Evaluation of Neutral Gd(III), Mn(II) Complexes From DTPA-Bisamide Derivative as Potential MRI Contrast Agents
作者: Liao, ZC; Li, CR; Yang, ZY(杨正银)
收录类别: SCIE
出版日期: 2016-05-03
刊名: SYNTHESIS AND REACTIVITY IN INORGANIC METAL-ORGANIC AND NANO-METAL CHEMISTRY
卷号: 46, 期号:5, 页码:653-658
出版者: TAYLOR & FRANCIS
出版地: PHILADELPHIA
英文摘要: A strong chelating ligand was synthesized through the modification of DTPA by bioactive 5-fluorouracil derivatives and characterized by means of mass spectra, Fourier transform infrared spectra, elemental analysis, and nuclear magnetic resonance spectroscopy. Its complexes of Gd(III) and Mn(II) were designed as potential MRI contrast agents. Thermodynamic stability constant of the complexes indicated that they were stable enough to prevent the metal ions from releasing. Relaxivity studies showed that the two complexes provided higher T-1-weighted relaxivity than that of commercial contrast agent Gd-DTPA and the Mn(II) complex owned much higher T-2-weighted relaxation property. Both the Gd(III) and Mn(II) complexes had the advantage of becoming promising T-1-weighted MRI contrast agents.
关键词: 5-fluorouracil derivatives ; DTPA-bisamide ; neutral complexes ; MRI contrast agents ; relaxivities
作者部门: [Liao, Zhen-Chuan ; Li, Chao-Rui ; Yang, Zheng-Yin] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
通讯作者: Yang, ZY (reprint author), Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China.
学科分类: Chemistry; Science & Technology - Other Topics
文章类型: Article
所属项目编号: National Natural Science Foundation of China [20975046, 81171337]
所属项目名称: 国家自然科学基金项目
项目资助者: NSFC
语种: 英语
DOI: 10.1080/15533174.2014.988820
ISSN号: 1553-3174
WOS记录号: WOS:000366393800006
IR记录号: WOS:000366393800006
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/180430
Appears in Collections:化学化工学院_期刊论文

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Recommended Citation:
Liao, ZC,Li, CR,Yang, ZY. Synthesis and Evaluation of Neutral Gd(III), Mn(II) Complexes From DTPA-Bisamide Derivative as Potential MRI Contrast Agents[J]. SYNTHESIS AND REACTIVITY IN INORGANIC METAL-ORGANIC AND NANO-METAL CHEMISTRY,2016,46(5):653-658.
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