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兰州大学机构库  > 化学化工学院  > 期刊论文
题名: Synthesis of Peptide Dendrimers and Their Application in the Drug Delivery System
其他题名: 肽类树状大分子的合成及其在药物传输系统中的应用
作者: Zhang, SF; Yang, JD; Liu, MZ(柳明珠); Lu, SY; Gao, CM; Wu, C; Zhu, ZY
收录类别: SCIE ; CSCD
出版日期: 2016-05-15
刊名: ACTA CHIMICA SINICA
卷号: 74, 期号:5, 页码:401-409
期刊主办单位: 中国科学院上海有机化学研究所 ; 中国化学会
出版者: SCIENCE CHINA PRESS
出版地: BEIJING
中文摘要: 树状大分子是近年来蓬勃发展的一类新型高分子材料, 其表面存在大量的官能团, 分子内部存在空腔且分子尺寸可控, 因此, 树状大分子已被广泛应用于众多的领域. 肽类树状大分子是指在树状大分子结构中含有肽键的一类大分子, 因其具有类似蛋白质一样的球状结构, 且具有优异的水溶性、生物相容性、生物降解性和细胞低毒性等特点, 所以, 肽类树状大分子可以作为药物传输的载体. 此外, 肽类树状大分子的疏水空腔可以装载疏水性药物, 对其起到增溶和缓释作用. 综述了肽类树状大分子的合成方法, 并对其与药物分子的结合机制及其在药物传输系统中的应用进行了总结与展望.
英文摘要: Dendrimers are a novel polymer material, which have received more and more attention due to the functional groups on their surface, hydrophobic cavity and adjustable sizes. Thus, dendrimers have been widely used in many fields. Peptide dendrimer is a sort of dendritic polymer, which contains peptide bonds in the structure. Owing to the globular structure similar to the protein, excellent water solubility, biocompatibility, biodegradability and low toxicity, peptide dendrimer could be used as drug delivery carrier. In addition, hydrophobic cavity can be used to solubilize hydrophobic drugs, in which the drugs can be released slowly. The present review highlights the current status of synthesis of peptide dendrimers, and it also summarizes and forecasts the interaction mechanism between drug molecules and peptide dendrimers, and the application of peptide dendrimers in drug delivery system.
关键词: polymer material ; peptide dendrimers ; globular structure ; drug delivery ; carrier
作者部门: [Zhang Shaofei ; Liu Mingzhu ; Lu Shaoyu ; Gao Chunmei ; Wu Can ; Zhu Zhaoyan] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China ; [Zhang Shaofei ; Yang Jiandong] Longnan Teachers Coll, Longnan 742500, Peoples R China
通讯作者: Liu, MZ (reprint author), Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China.
学科分类: Chemistry
文章类型: Review
所属项目编号: National Natural Science Foundation of China [51541304, 51273086] ; Special Doctorial Program Fund from the Ministry of Education of China [20130211110017] ; Key Research Project of Longnan Teacher's College [2014LSZK01004]
所属项目名称: 国家自然科学基金项目 ; 高等学校博士学科点专项科研基金
项目资助者: NSFC ; MOE
语种: 中文
DOI: 10.6023/A16020096
ISSN号: 0567-7351
WOS记录号: WOS:000377599700003
CSCD记录号: CSCD:5716442
IR记录号: WOS:000377599700003
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/180442
Appears in Collections:化学化工学院_期刊论文

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Recommended Citation:
Zhang, SF,Yang, JD,Liu, MZ,et al. Synthesis of Peptide Dendrimers and Their Application in the Drug Delivery System[J]. ACTA CHIMICA SINICA,2016,74(5):401-409.
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