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题名: Fabrication of Dual-Redox Responsive Supramolecular Copolymers Using a Reducible beta-Cyclodextran-Ferrocene Double-Head Unit
作者: Zuo, C; Dai, XY; Zhao, SJ; Liu, XN; Ding, SL; Ma, LW; Liu, MZ(柳明珠); Wei, H(魏华)
收录类别: SCIE
出版日期: 2016-07
刊名: ACS MACRO LETTERS
卷号: 5, 期号:7, 页码:873-878
英文摘要: Self-assembly of amphiphilic block copolymers into well-defined nanostructures as drug delivery systems for the treatment of cancer has been a hot subject of research. However, sequential polymerizations synthesized amphiphilic block copolymers with covalent links suffered mainly from multistep synthesis and purification procedures as well as repeated optimization of polymer composition to form aggregates with well-defined structures. To overcome these drawbacks, supramolecular amphiphilic block copolymers with noncovalent links were developed to provide simplicity as required. Herein, we designed and prepared a reducible beta-cyclodextran (beta-CD)-ferrocene (Fc) double-head unit from which a dual-redox responsive supra molecular amphiphilic copolymer was fabricated together with a traditional polymer block through supramolecular induced polymerization. Typically, well-defined supramolecular micelles and vesicles were fabricated, respectively. Due to the integration of oxidation-sensitive noncovalent beta-CD/Fc connections and reduction-sensitive covalent disulfide bridges in the polymer backbone, the resulting supramolecular micelles and vesicles showed structural deformation and accelerated drug release in response to both intracellular reducing and oxidizing environments, thus, presenting a new platform for both reactive oxygen species (ROS) and glutathione (GSH)-triggered anticancer drug delivery.
作者部门: [Wei, Hua] Lanzhou Univ, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Peoples R China ; Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China
通讯作者: Wei, H (reprint author), Lanzhou Univ, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Peoples R China.
学科分类: Polymer Science
文章类型: Article
所属项目编号: National Natural Science Foundation of China [51473072, 21504035] ; Fundamental Research Funds for the Central Universities [lzujbky-2015-k05, lzujbky-2016-ct05]
所属项目名称: 国家自然科学基金项目 ; 中央高校基本科研业务费专项资金
项目资助者: NSFC ; LZU
语种: 英语
DOI: 10.1021/acsmacrolett.6b00450
ISSN号: 2161-1653
WOS记录号: WOS:000380296000020
IR记录号: WOS:000380296000020
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/180488
Appears in Collections:化学化工学院_期刊论文

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Recommended Citation:
Zuo, C,Dai, XY,Zhao, SJ,et al. Fabrication of Dual-Redox Responsive Supramolecular Copolymers Using a Reducible beta-Cyclodextran-Ferrocene Double-Head Unit[J]. ACS MACRO LETTERS,2016,5(7):873-878.
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