兰州大学机构库 >化学化工学院
Fabrication of Dual-Redox Responsive Supramolecular Copolymers Using a Reducible beta-Cyclodextran-Ferrocene Double-Head Unit
Zuo, C; Dai, XY; Zhao, SJ; Liu, XN; Ding, SL; Ma, LW(马丽微); Liu, MZ(柳明珠); Wei, H(魏华); Wei, H (reprint author), Lanzhou Univ, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Peoples R China.
Indexed BySCIE
2016-07
Source PublicationACS MACRO LETTERS
Volume5Issue:7Pages:873-878
PublisherAMER CHEMICAL SOC
Publication PlaceWASHINGTON
AbstractSelf-assembly of amphiphilic block copolymers into well-defined nanostructures as drug delivery systems for the treatment of cancer has been a hot subject of research. However, sequential polymerizations synthesized amphiphilic block copolymers with covalent links suffered mainly from multistep synthesis and purification procedures as well as repeated optimization of polymer composition to form aggregates with well-defined structures. To overcome these drawbacks, supramolecular amphiphilic block copolymers with noncovalent links were developed to provide simplicity as required. Herein, we designed and prepared a reducible beta-cyclodextran (beta-CD)-ferrocene (Fc) double-head unit from which a dual-redox responsive supra molecular amphiphilic copolymer was fabricated together with a traditional polymer block through supramolecular induced polymerization. Typically, well-defined supramolecular micelles and vesicles were fabricated, respectively. Due to the integration of oxidation-sensitive noncovalent beta-CD/Fc connections and reduction-sensitive covalent disulfide bridges in the polymer backbone, the resulting supramolecular micelles and vesicles showed structural deformation and accelerated drug release in response to both intracellular reducing and oxidizing environments, thus, presenting a new platform for both reactive oxygen species (ROS) and glutathione (GSH)-triggered anticancer drug delivery.
Department[Wei, Hua] Lanzhou Univ, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Peoples R China;
Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China
Subject AreaPolymer Science
Project NumberNational Natural Science Foundation of China [51473072, 21504035] ; Fundamental Research Funds for the Central Universities [lzujbky-2015-k05, lzujbky-2016-ct05]
Funding Project国家自然科学基金项目 ; 中央高校基本科研业务费专项资金
Funding OrganizationNSFC ; LZU
DOI10.1021/acsmacrolett.6b00450
ISSN2161-1653
SubtypeArticle
Language英语
WOS IDWOS:000380296000020
IRIDWOS:000380296000020
First Inst
Citation statistics
Cited Times:26[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.lzu.edu.cn/handle/262010/180488
Collection化学化工学院
Corresponding AuthorWei, H (reprint author), Lanzhou Univ, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Peoples R China.
Recommended Citation
GB/T 7714
Zuo, C,Dai, XY,Zhao, SJ,et al. Fabrication of Dual-Redox Responsive Supramolecular Copolymers Using a Reducible beta-Cyclodextran-Ferrocene Double-Head Unit[J]. ACS MACRO LETTERS,2016,5(7):873-878.
APA Zuo, C.,Dai, XY.,Zhao, SJ.,Liu, XN.,Ding, SL.,...&Wei, H .(2016).Fabrication of Dual-Redox Responsive Supramolecular Copolymers Using a Reducible beta-Cyclodextran-Ferrocene Double-Head Unit.ACS MACRO LETTERS,5(7),873-878.
MLA Zuo, C,et al."Fabrication of Dual-Redox Responsive Supramolecular Copolymers Using a Reducible beta-Cyclodextran-Ferrocene Double-Head Unit".ACS MACRO LETTERS 5.7(2016):873-878.
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