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兰州大学机构库  > 化学化工学院  > 期刊论文
题名: Novel fluorescent pH/reduction dual stimuli-responsive polymeric nanoparticles for intracellular triggered anticancer drug release
作者: Jia, X; Zhao, X; Tian, K; Zhou, TT; Li, JG; Zhang, RN; Liu, P(刘鹏)
收录类别: SCIE ; EI ; BIOSIS
出版日期: 2016-07-01
刊名: CHEMICAL ENGINEERING JOURNAL
卷号: 295, 页码:468-476
英文摘要: Fluorescent poly(methacrylic acid-co-poly(ethylene glycol) methyl ether methacrylate-co-N'-rhodamine B-acrylhydrazine) (P(MAA-co-PEGMA-co-RhBAh), PMPR) nanoparticles were designed as pH/reduction dual stimuli-responsive drug delivery system (DDS) for anti-cancer drug via facile distillation precipitation copolymerization with bio-reducible disulfide-containing crosslinker. As a carrier for doxorubicin (DOX), high drug-loading capacity (DLC) and drug-loading efficiency (DLE) of 53.1% and 97.3% were achieved respectively, via the strong electrostatic interaction between the carboxyl groups of PMAA segments and the amino group of DOX. Due to the disulfide crosslinking structure and their drug-loading mode, the DOX-loaded PMPR nanoparticles were relatively stable under extracellular conditions with low drug leakage, while a rapid intracellular drug release took place in acidic and reductive environment of tumor cells. The fluorescence microscope analysis showed that the DOX-loaded PMPR nanoparticles could be successfully endocytosed by HepG2 cells and the released DOX was mainly accumulated in cell nuclei. These features make them potential DDS for tumor-environment-responsive controlled release. Furthermore, the PMPR nanoparticles showed strong fluorescence only at low pH media, which might be used for the real-time fluorescent imaging in cancer diagnosis as a potential theranostic nanoplatform for imaging-guided therapy of cancer. (C) 2016 Elsevier B.V. All rights reserved.
关键词: Drug delivery system ; Polymeric nanoparticles ; Controlled release ; Tumor-environment-responsive ; Fluorescent imaging
作者部门: [Liu, Peng] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China ; Lanzhou Univ, Coll Chem & Chem Engn, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Peoples R China
通讯作者: Liu, P (reprint author), Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China.
学科分类: Engineering
文章类型: Article
所属项目编号: National Nature Science Foundation of China [20904017] ; Program for New Century Excellent Talents in University of the Ministry of Education of China [NCET-09-0441]
所属项目名称: 国家自然科学基金项目 ; 新世纪优秀人才支持计划
项目资助者: NSFC ; MOE
语种: 英语
DOI: 10.1016/j.cej.2016.03.065
ISSN号: 1385-8947
WOS记录号: WOS:000375507300051
EI记录号: 20161302168394
BIOSIS记录号: BCI:BCI201600484112
IR记录号: WOS:000375507300051
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/180491
Appears in Collections:化学化工学院_期刊论文

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Recommended Citation:
Jia, X,Zhao, X,Tian, K,et al. Novel fluorescent pH/reduction dual stimuli-responsive polymeric nanoparticles for intracellular triggered anticancer drug release[J]. CHEMICAL ENGINEERING JOURNAL,2016,295:468-476.
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