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题名: pH/Reductant Dual-Responsive Core-Cross-Linked Micelles via Facile in Situ ATRP for Tumor-Targeted Delivery of Anticancer Drug with Enhanced Anticancer Efficiency
作者: Tian, K; Jia, X; Zhao, XB; Liu, P(刘鹏)
收录类别: SCIE ; PubMed ; BIOSIS
出版日期: 2016-08
刊名: MOLECULAR PHARMACEUTICS
卷号: 13, 期号:8, 页码:2683-2690
出版者: AMER CHEMICAL SOC
出版地: WASHINGTON
英文摘要: Anticancer drugs cause severe side effects on normal tissues and organs due to their nonspecific delivery. Thus, tumor-targeting delivery of anticancer drugs remains a serious challenge in chemotherapy. Here a facile strategy was established for the pH/reductant dual-responsive core-cross-linked (CCL) micelles for tumor-targeted delivery of anticancer drug, via in situ atom transfer radical polymerization (ATRP). In the in vitro controlled release experiments with doxorubicin (DOX) as a model drug, the premature drug leakage rate was only 13.4% in the physiological medium within 36 h, while the cumulative release rate in the stimulated tumor microenvironment reached 78.7%, demonstrating the excellent tumor microenvironment responsive controlled release behavior upon acidic medium with high GSH level. As a folate receptor (FR) mediated targeting drug delivery system (DDS), the micelles showed excellent cytocompatibility, and enhanced anticancer efficiency after loading of DOX, compared with free DOX.
关键词: drug delivery system ; tumor targeting ; core-cross-linked micelles ; controlled release ; tumor microenvironment responsive
作者部门: [Liu, Peng] Lanzhou Univ, State Key Lab Appl Organ Chem, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China ; Lanzhou Univ, Key Lab Nonferrous Met Chem & Resources Utilizat, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China
通讯作者: Liu, P (reprint author), Lanzhou Univ, State Key Lab Appl Organ Chem, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China.
学科分类: Research & Experimental Medicine; Pharmacology & Pharmacy
文章类型: Article
所属项目编号: National Nature Science Foundation of China [20904017] ; Program for New Century Excellent Talents in University [NCET-09-0441]
所属项目名称: 国家自然科学基金项目 ; 新世纪优秀人才支持计划
项目资助者: NSFC ; MOE
语种: 英语
DOI: 10.1021/acs.molpharmaceut.6b00241
ISSN号: 1543-8384
WOS记录号: WOS:000380864800010
PM记录号: 27379461
BIOSIS记录号: BCI:BCI201600700182
IR记录号: WOS:000380864800010
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内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/180519
Appears in Collections:化学化工学院_期刊论文

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Recommended Citation:
Tian, K,Jia, X,Zhao, XB,et al. pH/Reductant Dual-Responsive Core-Cross-Linked Micelles via Facile in Situ ATRP for Tumor-Targeted Delivery of Anticancer Drug with Enhanced Anticancer Efficiency[J]. MOLECULAR PHARMACEUTICS,2016,13(8):2683-2690.
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