化学化工学院机构知识库

Institutional Repository, College of Chemistry and Chemical Engineering

 

兰州大学机构库  > 化学化工学院  > 期刊论文
题名: Synthesis of Photo- and pH Dual-Sensitive Amphiphilic Copolymer PEG(43)-b-P(AA(76)-co-NBA(35)-co-tBA(9)) and Its Micellization as Leakage-Free Drug Delivery System for UV-Triggered Intracellular Delivery of Doxorubicin
其他题名: Synthesis of Photo- and pH Dual-Sensitive Amphiphilic Copolymer PEG43-b-P(AA76-co-NBA35-co-tBA9) and Its Micellization as Leakage-Free Drug Delivery System for UV-Triggered Intracellular Delivery of Doxorubicin
作者: Zhao, XB; Qi, MZ; Liang, S; Tian, K; Zhou, TT; Jia, X; Li, JG; Liu, P(刘鹏)
收录类别: SCIE ; EI ; MEDLINE
出版日期: 2016-08-31
刊名: ACS APPLIED MATERIALS & INTERFACES
卷号: 8, 期号:34, 页码:22127-22134
英文摘要: Novel photo- and pH dual-sensitive amphiphilic copolymers containing photolabile o-nitrobenzyl (NB) groups were designed via combination of ATRP, hydrolyzation, and simple esterification reaction and self-assembled into stimuli-regulated amphiphilic micelles in aqueous solution. On the basis of the optimization of the morphology and particle size of the micelles via, modulating the number of the photocleavable o-nitrobenzyl acrylate (NBA), units, the unique ones assembled from PEG(43)-b-P(AA(76)-co-NBA(35)-co-tBA(9)) with an average hydrodynamic diameter (D-h) of 163 nm was selected as a potential drug delivery system (DDS) for UV-triggered delivery of doxorubicin (DOX). The micelles possessed a favorable drug-loading capacity (DLC) of 27.5%, with the hydrodynamic diameter of 213 nm after DOX-loading. Most importantly, the DOX-loaded PEG(43)-b-P(AA(76)-co-NBA(35)-co-tBA(9)) micelles exhibited cumulative DOX release ratio of only 3.69% in the simulated physiological medium within 6 days without UV-irradiation, indicating their potential as leakage-free DDS. As in the acidic media mimicking the tumor microenvironment, a high cumulative DOX release ratio of 74.70% was achieved within 6 days after UV-irradiation for 20 min, showing a sustained release behavior. Under UV-irradiation, the photolabile p-nitrobenzyl moieties were cleaved off, the amphiphilic copolymer transformed into a water-soluble polymer, favoring the metabolism of drug carriers, and the micelles were demicellized to accelerate the drug release in a triggered or on demand manner.
关键词: drug delivery system ; UV-triggered delivery ; leakage-free ; micelle ; photosensitive amphiphilic copolymer
作者部门: [Liu, Peng] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China ; [Liu, Peng] Lanzhou Univ, Coll Chem & Chem Engn, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Peoples R China
通讯作者: Liu, P (reprint author), Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China. ; Liu, P (reprint author), Lanzhou Univ, Coll Chem & Chem Engn, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Peoples R China.
学科分类: Science & Technology - Other Topics; Materials Science
文章类型: Article
所属项目编号: National Nature Science Foundation of China [20904017] ; Program for New Century Excellent Talents in University [NCET-09-0441] ; National Science Foundation for Fostering Talents in Basic Research of the National Natural Science Foundation of China [J1103307]
所属项目名称: 国家自然科学基金项目 ; 国家基础科学人才培养基金项目 ; 新世纪优秀人才支持计划
项目资助者: NSFC ; MOE
语种: 英语
DOI: 10.1021/acsami.6b08935
ISSN号: 1944-8244
WOS记录号: WOS:000382514100033
EI记录号: 20163702787888
PM记录号: 27513439
IR记录号: WOS:000382514100033
第一机构:
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/180554
Appears in Collections:化学化工学院_期刊论文

Files in This Item:

There are no files associated with this item.


Recommended Citation:
Zhao, XB,Qi, MZ,Liang, S,et al. Synthesis of Photo- and pH Dual-Sensitive Amphiphilic Copolymer PEG(43)-b-P(AA(76)-co-NBA(35)-co-tBA(9)) and Its Micellization as Leakage-Free Drug Delivery System for UV-Triggered Intracellular Delivery of Doxorubicin[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(34):22127-22134.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Altmetrics Score
 
Google Scholar
Similar articles in Google Scholar
[Zhao, XB]'s Articles
[Qi, MZ]'s Articles
[Liang, S]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhao, XB]‘s Articles
[Qi, MZ]‘s Articles
[Liang, S]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Email:
Passwd
验 证:
换一张
Have you forgotten your password? Log In
Copyright © 2007-2017  兰州大学 - Feedback
Powered by CSpace