化学化工学院机构知识库

Institutional Repository, College of Chemistry and Chemical Engineering

 

兰州大学机构库  > 化学化工学院  > 期刊论文
题名: Mucoadhesive microparticulates based on polysaccharide for target dual drug delivery of 5-aminosalicylic acid and curcumin to inflamed colon.
其他题名: Mucoadhesive microparticulates based on polysaccharide for target dual drug delivery of 5-aminosalicylic acid and curcumin to inflamed colon
作者: Duan, Haogang; Lu, Shaoyu; Gao, Chunmei; Bai, Xiao; Qin, Hongyan; Wei, Yuhui; Wu, Xin'an; Liu, MZ(柳明珠)
收录类别: SCIE ; EI ; MEDLINE
出版日期: 2016-09-01
刊名: COLLOIDS AND SURFACES B-BIOINTERFACES
卷号: 145, 页码:510-519
出版者: ELSEVIER
出版地: AMSTERDAM
英文摘要: In this work, thiolated chitosan/alginate composite microparticulates (CMPs) coated by Eudragit S-100 were developed for colon-specific delivery of 5-aminosalicylic acid (5-ASA) and curcumin (CUR), and the use of it as a multi drug delivery system for the treatment of colitis. The physicochemical properties of the CMPs were evaluated. In vitro release was performed in gradually pH-changing medium simulating the conditions of different parts of GIT, and the results showed that the Eudragit S-100 coating has a pH-sensitive release property, which can avoid drug being released at a pH lower than 7. An everted sac method was used to evaluate the mucoadhesion of CMPs. Ex vivo mucoadhesive tests showed CMPs have excellent mucosa adhesion for the colonic mucosa of rats. In vivo treatment effect of enteric microparticulates systems was evaluated in colitis rats. The results showed superior therapeutic efficiency of this drug delivery system for the colitis rats induced by TNBS. Therefore, the enteric microparticulates systems combined the properties of pH dependent delivery, mucoadhesive, and control release, and could be an available tool for the treatment of human inflammatory bowel disease. (C) 2016 Elsevier B.V. All rights reserved.
关键词: Thiolated chitosan ; Alginate ; Colon-specific delivery ; Mucoadhesive microparticulate ; Inflammatory bowel disease
作者部门: Department of Chemistry, Lanzhou University, Lanzhou 730000, PR China ; Department of Pharmacy, The First Hospital of Lanzhou University, Lanzhou 730000, PR China.
通讯作者: Liu, MZ (reprint author), Lanzhou Univ, Dept Chem, Lanzhou 730000, Peoples R China.
学科分类: Biophysics; Chemistry; Materials Science
文章类型: Article
语种: 英语
DOI: 10.1016/j.colsurfb.2016.05.038
ISSN号: 0927-7765
WOS记录号: WOS:000381171800060
EI记录号: 20162202443943
PM记录号: 27239905
IR记录号: 27239905
第一机构:
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.lzu.edu.cn/handle/262010/180561
Appears in Collections:化学化工学院_期刊论文

Files in This Item:

There are no files associated with this item.


Recommended Citation:
Duan, Haogang,Lu, Shaoyu,Gao, Chunmei,et al. Mucoadhesive microparticulates based on polysaccharide for target dual drug delivery of 5-aminosalicylic acid and curcumin to inflamed colon.[J]. Colloids and surfaces. B, Biointerfaces,2016,145:510-519.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Altmetrics Score
 
Google Scholar
Similar articles in Google Scholar
[Duan, Haogang]'s Articles
[Lu, Shaoyu]'s Articles
[Gao, Chunmei]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Duan, Haogang]‘s Articles
[Lu, Shaoyu]‘s Articles
[Gao, Chunmei]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Email:
Passwd
验 证:
换一张
Have you forgotten your password? Log In
Copyright © 2007-2017  兰州大学 - Feedback
Powered by CSpace